搜索范围
03240595
应用筛选条件
关键词:'03240595'
显示 1-30 #N/A 63 条结果 关于 "03240595" 范围 论文
Yumiko Achiwa et al.
Bioscience, biotechnology, and biochemistry, 71(1), 31-37 (2007-01-11)
The phosphatidylinositol 3-kinase-Akt (PI3K-Akt) pathway and the mitogen activated protein kinase (MAPK) pathway are important in the development and proliferation of various human cancers. It has been found recently that ursolic acid treatment affects growth and apoptosis in cancer cells.
Shuilong Leng et al.
International journal of cancer, 133(12), 2781-2790 (2013-06-06)
Ursolic acid (UA) has been reported to possess anticancer activities. Although some of the anticancer activities of UA have been explained by its apoptosis-inducing properties, the mechanisms underlying its anticancer actions are largely unknown. We have found that UA-activated autophagy
Katerina Naumoska et al.
Journal of chromatography. A, 1381, 229-238 (2015-01-20)
Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red
Marcin Broniatowski et al.
Biochimica et biophysica acta, 1838(10), 2530-2538 (2014-06-08)
Pentacyclic triterpene acids (PTAs): betulinic (BAc), oleanolic (Ola) and ursolic (Urs) are potent pharmaceuticals applied in the therapy of cancer and bacterial infections. The mechanism of PTA action is multifactor, but the important step is their interaction with the lipids
Riki Ogasawara et al.
American journal of physiology. Endocrinology and metabolism, 305(6), E760-E765 (2013-08-01)
A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling. The purpose of
Burcu Çulhaoğlu et al.
Natural product research, 27(4-5), 438-447 (2012-11-07)
The dichloromethane extract of the aerial parts of Salvia chrysophylla Stapf (Lamiaceae), which is an endemic species to south-western Anatolia, was studied for non-volatile secondary metabolites for the first time in this study. Structures of the isolated compounds were elucidated
Fang Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(9), 1378-1385 (2013-08-16)
Eighteen compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, MCI gel, silica gel, and sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic data analysis as adinoside A (1), stryspinoside
Uppuluri V Mallavadhania et al.
Natural product communications, 9(12), 1687-1690 (2015-01-30)
Ursolic acid (1), a natural pentacyclic triterpenic acid, afforded a variety of ring-C transformed products (5-11) when treated with N-bromosuccinimide under the influence of a range of protective groups and solvents. The synthesized compounds have been evaluated for cytotoxic activity
Josimar de Oliveira Eloy et al.
AAPS PharmSciTech, 13(4), 1436-1445 (2012-10-17)
Solid dispersions (SDs) are an approach to increasing the water solubility and bioavailability of lipophilic drugs such as ursolic acid (UA), a triterpenoid with trypanocidal activity. In this work, Gelucire 50/13, a surfactant compound with permeability-enhancing properties, and silicon dioxide
Jie Liu
Journal of ethnopharmacology, 100(1-2), 92-94 (2005-07-05)
Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet. During the last decade over 700 research articles have been published on their research, reflecting tremendous interest and progress
Bartłomiej Micota et al.
Acta biochimica Polonica, 61(2), 385-388 (2014-06-12)
The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion
Zi-Ming Chen et al.
Steroids, 87, 21-25 (2014-06-01)
Three novel degraded steroids, named albocisterols A-C (1-3), have been isolated from cultures of Antrodiella albocinnamomea. Their structures were defined by comprehensive spectroscopic analysis and single crystal X-ray crystallography. The mixture of compounds 2 and 3 exhibited significant inhibitory activities
Xinxing Lu et al.
PloS one, 10(2), e0117400-e0117400 (2015-02-18)
To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions. Rat glomerular mesangial cells were
Kishor Mazumder et al.
Molecules (Basel, Switzerland), 18(8), 8929-8944 (2013-07-31)
Structure-activity relationships of ursane-type pentacyclic triterpenes obtained from natural sources and by chemical derivatization are reviewed. Ursolic acid, corosolic acid, and a new ursane-type pentacyclic triterpene, 7,24-dihydroxyursolic acid, were isolated from the methanolic extract of the leaves of the Bangladeshi
Allisson Jhonatan Gomes Castro et al.
Biochimica et biophysica acta, 1850(1), 51-61 (2014-10-15)
The effect of in vivo treatment with ursolic acid (UA) on glycemia in hyperglycemic rats and its mechanism of action on muscle were studied. The UA effects on glycemia, glycogen, LDH, calcium and on insulin levels were evaluated after glucose
Augusta Caligiani et al.
Food chemistry, 136(2), 735-741 (2012-11-06)
The occurrence of triterpene pentacyclic acids in plants is extensive, but little is known about their availability in commercial extracts. A simple GC-MS method for the simultaneous determination of betulinic, corosolic, maslinic, oleanolic and ursolic acids was developed and applied
Xiangjun Chen et al.
Immunotherapy, 5(1), 39-47 (2012-12-22)
To assess whether ursolic acid (UA) can attenuate lipopolysachharide (LPS)-induced acute lung injury and improve the survival time in a mouse model. The mice were challenged with LPS and survival time was monitored from 0-96 h after LPS treatment. TNF-α
Hye Yoom Kim et al.
Life sciences, 94(2), 145-150 (2013-12-18)
Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria. The present study was designed to clarify the regulatory effects of ursolic acid on the β-adrenergic or muscarinic receptor-mediated changes
Seung-Hyung Kim et al.
European journal of pharmacology, 701(1-3), 131-143 (2012-12-04)
Allergic asthma is a chronic airway disorder characterized by airway hyperresponsiveness to allergens, chronic airway inflammation, airway edema, increased mucus secretion, excess production of Th2 cytokines, and eosinophil accumulation in the lungs. Ursolic acid is known for its pharmacological effects
Ling Liu et al.
Molecular medicine reports, 9(6), 2505-2511 (2014-03-19)
Cyclooxygenase (COX)-2, a multi-functional molecule, is overexpressed in hepatocellular carcinomas. In order to understand cell proliferation and its association with COX-2 in HepG2 cells in the presence of ursolic acid (UA), viili exopolysaccharides (VEPS) and Astragalus polysaccharides (APS), the cell
Huijun Yan et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(15), 2280-2285 (2012-11-30)
To conduct the biotransformation of ursolic acid by alternaria longipes AS3. 2875, and optimize the culture medium and biotransformation conditions. With the consumption rate of ursolic acid and the generation rate of 28-O-beta-D-glucopyranose ursolic acid as indicators, the impact of
Jin Lee et al.
Indian journal of experimental biology, 52(7), 683-691 (2014-07-26)
Ursolic acid (UA) is a pentacyclic triterpenoid compound that naturally occurs in fruits, leaves and flowers of medicinal herbs. This study investigated the dose-response efficacy of UA (0.01 and 0.05%) on glucose metabolism, the polyol pathway and dyslipidemia in streptozotocin/nicotinamide-induced
Arjunan Sundaresan et al.
General physiology and biophysics, 31(3), 323-333 (2012-10-11)
The aim of this study was to examine the combined effect of ursolic acid (UA) and rosiglitazone (RSG) on metabolic syndrome in C57BL/6J mice. Upon feeding high fat diet (HFD) C57BL/6J mice developed obesity, insulin resistance, dyslipidemia and hypertension. The
Cheng-Song Liu et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(6), 908-910 (2012-12-15)
To study the chemical constituents of Gentiana striata. The constituents were isolated from the whole herb of Gentiana striata by recrystalization, silica gel column chromatography, polyamide column chromatography and Sephadex LH-20,etc. Their structures were elucidated through MS, 1H-NMR, 13C-NMR. -8
András Lőrincz et al.
Biochimica et biophysica acta, 1848(5), 1092-1098 (2015-01-27)
Effects of ursolic acid on the structural and morphological characteristics of dipalmitoyl lecithin(DPPC)-water system was studied by using differential scanning calorimetry (DSC), small- and wide-angle X-ray scattering (SWAXS), freeze-fracture method combined with transmission electron-microscopy (FF-TEM) and infrared spectroscopy (FT-IR). The
Renata Nowak et al.
Acta poloniae pharmaceutica, 70(3), 413-418 (2013-06-14)
Spices play an important role in the chemoprevention and they can be a rich source of biologically active compounds such as triterpenes in the human diet. A method based on high performance thin-layer chromatography combined with densitometry for determination of
Y Estornes et al.
Cell death & disease, 5, e1555-e1555 (2014-12-06)
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis. However, when the stress is too severe the UPR switches from
Gloria N S da Silva et al.
Malaria journal, 12, 89-89 (2013-03-19)
The discovery and development of anti-malarial compounds of plant origin and semisynthetic derivatives thereof, such as quinine (QN) and chloroquine (CQ), has highlighted the importance of these compounds in the treatment of malaria. Ursolic acid analogues bearing an acetyl group
Chong Zhao et al.
Autophagy, 9(2), 196-207 (2012-11-28)
Ursolic acid (UA) is a pentacyclic triterpenoid with promising cancer chemopreventive properties. A better understanding of the mechanisms underlying anticancer activity of UA is needed for further development as a clinically useful chemopreventive agent. Here, we found that both endoplasmic
Alexia Agiomyrgianaki et al.
Magnetic resonance in chemistry : MRC, 50(11), 739-748 (2012-09-25)
(31)P nuclear magnetic resonance (NMR) spectroscopy was used to detect and quantify simultaneously a large number of phenolic compounds and the two triterpenic acids, ursolic acid and oleanolic acid, extracted from two oregano species Origanum onites and Origanum vulgare ssp.
1/3