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M V Chakravarthy et al.
The Journal of biological chemistry, 275(46), 35942-35952 (2000-08-30)
Interest is growing in methods to extend replicative life span of non-immortalized stem cells. Using the insulin-like growth factor I (IGF-I) transgenic mouse in which the IGF-I transgene is expressed during skeletal muscle development and maturation prior to isolation and
Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.
Bjarki Stefansson et al.
Cell cycle (Georgetown, Tex.), 6(11), 1386-1392 (2007-06-15)
Yeast SIT4 is an essential gene encoding a protein Ser/Thr phosphatase conserved throughout eukaryotic evolution, known as PPV in Drosophila and PP6 in vertebrates. Sit4 promotes transcription of G1 cyclins and a sit4(ts) strain exhibits a G1 arrest at the
Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals.
Shuichi Machida, Frank W Booth
Experimental Gerontology null
Cell cycle. Stifled by inhibitions.
Peters, G
Nature, 371, 204-205 (1994)
Chaoxuan Dong et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 101(5), 355-363 (2014-09-19)
Ketamine is widely used as an anesthetic, analgesic, or sedative in pediatric patients. We reported that ketamine alters the normal neurogenesis of rat fetal neural stem progenitor cells (NSPCs) in the developing brain, but the underlying mechanisms remain unknown. The
Nagalingam R Sundaresan et al.
Nature medicine, 18(11), 1643-1650 (2012-10-23)
Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway are not completely understood. Here we show that sirtuin 6
Yan Guo et al.
iScience, 25(7), 104519-104519 (2022-06-28)
Aging is an intricate process characterized by multiple hallmarks including stem cell exhaustion, genome instability, epigenome alteration, impaired proteostasis, and cellular senescence. Whereas each of these traits is detrimental at the cellular level, it remains unclear how they are interconnected
High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor.
Walters, BJ; Lin, W; Diao, S; Brimble, M; Iconaru, LI; Dearman, J; Goktug, A; Chen, T; Zuo, J
Testing null
S Persad et al.
The Journal of cell biology, 153(6), 1161-1174 (2001-06-13)
beta-Catenin is a protein that plays a role in intercellular adhesion as well as in the regulation of gene expression. The latter role of beta-catenin is associated with its oncogenic properties due to the loss of expression or inactivation of
Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells.
Shuichi Machida, Espen E Spangenburg, Frank W Booth
Journal of Cellular Physiology null
Masahiro Morita et al.
Molecular and cellular biology, 27(13), 4980-4990 (2007-04-25)
The stability of mRNA influences the abundance of cellular transcripts and proteins. Deadenylases play critical roles in mRNA turnover and thus are important for the regulation of various biological events. Here, we report the identification and characterization of CCR4b/CNOT6L, which
Sooncheol Lee et al.
Genome biology, 21(1), 33-33 (2020-02-11)
Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcriptional regulation contributes to their chemoresistance remains
Binghui Li et al.
Blood, 107(11), 4291-4299 (2006-02-10)
As erythroid progenitors differentiate into precursors and finally mature red blood cells, lineage-specific genes are induced, and proliferation declines until cell cycle exit. Cul4A encodes a core subunit of a ubiquitin ligase that targets proteins for ubiquitin-mediated degradation, and Cul4A-haploinsufficient
W Tian et al.
Tissue antigens, 72(6), 559-567 (2008-12-05)
In this study, we investigated the five polymorphic Alu loci located within human major histocompatibility complex (MHC) class I region in 445 individuals from four distinct Chinese populations: Hunan Han, Inner Mongolia Han, Inner Mongolia Mongol and Guangdong Han populations
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