13160

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Two-phase hollow fiber liquid phase microextraction based on magnetofluid for simultaneous determination of Echinacoside, Tubuloside B, Acteoside and Isoacteoside in rat plasma after oral administration of Cistanche salsa extract by high performance liquid chromatography.

Jun Zhou et al.

Journal of pharmaceutical and biomedical analysis, 94, 30-35 (2014-02-18)

A new and fast sample preparation technique based on two-phase hollow fiber liquid phase microextraction (HF-LPME) with magnetofluid was developed to quantitate and determine the four phenylethanoid glycosides (PhGs) (Echinacoside, Tubuloside B, Acteoside and Isoacteoside) in plasma after oral administration

The plant cytoskeleton controls regulatory volume increase.

Qiong Liu et al.

Biochimica et biophysica acta, 1828(9), 2111-2120 (2013-05-11)

The ability to adjust cell volume is required for the adaptation to osmotic stress. Plant protoplasts can swell within seconds in response to hypoosmotic shock suggesting that membrane material is released from internal stores. Since the stability of plant membranes

Multiphoton microscopy of cleared mouse brain expressing YFP.

Sonia G Parra et al.

Journal of visualized experiments : JoVE, (67)(67), e3848-e3848 (2012-10-02)

Multiphoton microscopy of intrinsic fluorescence and second harmonic generation (SHG) of whole mouse organs is made possible by optically clearing the organ before imaging.(1,2) However, for organs that contain fluorescent proteins such as GFP and YFP, optical clearing protocols that

Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins.

Kyra J Barnes et al.

European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24)

To investigate the potential inhibitory effects of uremic toxins on the major human hepatic drug-metabolising cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in vitro. Benzyl alcohol, p-cresol, indoxyl sulfate, hippuric acid and a combination of the four uremic toxins were

Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.

Laura A Jones et al.

The Journal of cell biology, 207(4), 499-516 (2014-11-26)

Cytoplasmic dynein 1 (dynein) is a minus end-directed microtubule motor protein with many cellular functions, including during cell division. The role of the light intermediate chains (LICs; DYNC1LI1 and 2) within the complex is poorly understood. In this paper, we

Synthesis and accumulation of aromatic aldehydes in an engineered strain of Escherichia coli.

Aditya M Kunjapur et al.

Journal of the American Chemical Society, 136(33), 11644-11654 (2014-07-31)

Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances, and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by rapid, endogenous, and redundant conversion of aldehydes to their corresponding alcohols. We report the construction of an Escherichia

Synthesis and characterization of multi-alkali-metal tetraphenolates and application in ring-opening polymerization of lactide.

Jinjin Zhang et al.

Inorganic chemistry, 51(24), 13380-13389 (2012-12-12)

A series of alkali metal complexes supported by two bulky tetraphenols were synthesized and characterized. The reactions of α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-p-xylene(para-tetraphenol) with (n)BuLi, sodium, and KSi(NMe(2))(3) gave bimetallic complexes 1, 2, and 3, respectively. Treatments of the α,α,α',α'-tetra(3,5-di-tert-butyl-2-hydroxyphenyl)-m-xylene(meta-tetraphenol) with 2 or 4

Inelastic electron tunneling spectroscopic study of biological compounds in human sweat adsorbed on alumina.

M Higo et al.

Analytical chemistry, 66(6), 818-823 (1994-03-15)

Inelastic electron tunneling spectroscopy has been used for the detection and characterization of biological compounds in human sweat adsorbed on alumina surfaces. The sweat was collected from students and distributed to aqueous and benzene phases by solvent extraction. Both solutions

Anti-tumor promoting effect of glycosides from Prunus persica seeds.

Toshiyuki Fukuda et al.

Biological & pharmaceutical bulletin, 26(2), 271-273 (2003-02-11)

Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting

Stratum corneum lipid removal by surfactants: relation to in vivo irritation.

C L Froebe et al.

Dermatologica, 181(4), 277-283 (1990-01-01)

The relationship between the in vivo irritation potential of sodium lauryl sulfate (SLS) and linear alkyl benzene sulfonate (LAS) and the ability of these two surfactants to remove lipid from the stratum corneum (SC) in vitro were investigated. Either surfactant

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

Giulia Caron et al.

Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in

High efficiency light harvesting by carotenoids in the LH2 complex from photosynthetic bacteria: unique adaptation to growth under low-light conditions.

Nikki M Magdaong et al.

The journal of physical chemistry. B, 118(38), 11172-11189 (2014-08-30)

Rhodopin, rhodopinal, and their glucoside derivatives are carotenoids that accumulate in different amounts in the photosynthetic bacterium, Rhodoblastus (Rbl.) acidophilus strain 7050, depending on the intensity of the light under which the organism is grown. The different growth conditions also

Dynamic contrast-enhanced micro-computed tomography correlates with 3-dimensional fluorescence ultramicroscopy in antiangiogenic therapy of breast cancer xenografts.

Thomas Pöschinger et al.

Investigative radiology, 49(7), 445-456 (2014-03-07)

Dynamic contrast-enhanced (DCE) micro-computed tomography (micro-CT) has emerged as a valuable imaging tool to noninvasively obtain quantitative physiological biomarkers of drug effect in preclinical studies of antiangiogenic compounds. In this study, we explored the ability of DCE micro-CT to assess

Epidural administration of methylprednisolone acetate preserved with benzyl alcohol.

C C King et al.

The Annals of pharmacotherapy, 28(1), 59-60 (1994-01-01)

Excision biopsy in a patient with suspected local anaesthetic allergy: use of 0.9% saline with benzyl alcohol as local anaesthesia.

V M L Jolliffe et al.

Clinical and experimental dermatology, 37(8), 862-864 (2012-11-23)

Dermatologists may see patients with actual or suspected local anaesthetic (LA) allergy who require an urgent dermatological procedure to be performed without time for formal allergy testing. We report a case of shave biopsy and subsequent excision biopsy of an

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Peter J McNamara et al.

Antimicrobial agents and chemotherapy, 53(5), 1898-1906 (2009-02-19)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have shown that tampon additives can influence staphylococcal TSST-1 production. We report here on

Effects of sucrose and benzyl alcohol on GCSF conformational dynamics revealed by hydrogen deuterium exchange mass spectrometry.

Jun Zhang et al.

Journal of pharmaceutical sciences, 104(5), 1592-1600 (2015-02-20)

Protein stability, one of the major concerns for therapeutic protein development, can be optimized during process development by evaluating multiple formulation conditions. This can be a costly and lengthy procedure where different excipients and storage conditions are tested for their

Extension of a dynamic headspace multi-volatile method to milliliter injection volumes with full sample evaporation: Application to green tea.

Nobuo Ochiai et al.

Journal of chromatography. A, 1421, 103-113 (2015-08-16)

An extension of multi-volatile method (MVM) technology using the combination of a standard dynamic headspace (DHS) configuration, and a modified DHS configuration incorporating an additional vacuum module, was developed for milliliter injection volume of aqueous sample with full sample evaporation.

Macromolecular prodrugs. IXX. Kinetics of hydrolysis of benzyl dextran carbonate ester conjugates in aqueous buffer solutions and human plasma.

H Weibel et al.

Acta pharmaceutica Nordica, 3(3), 159-162 (1991-01-01)

Benzyl carbonate esters of dextran with varying degrees of substitution have been synthesized. The kinetics of the hydrolytic cleavage of the carbonate ester bond in aqueous solution within the pH range 0.44-10.46 (37 degrees C) has been investigated. The degradation

Acetonitrile adduct formation as a sensitive means for simple alcohol detection by LC-MS.

Roy Bogseth et al.

Journal of the American Society for Mass Spectrometry, 25(11), 1987-1990 (2014-09-25)

Simple alcohols formed protonated acetonitrile adducts containing up to two acetonitrile molecules when analyzed by ESI or APCI in the presence of acetonitrile in the solvent. These acetonitrile adducts underwent dissociation to form a nitrilium ion, also referred to as

Benzyl alcohol metabolism and elimination in neonates.

M LeBel et al.

Developmental pharmacology and therapeutics, 11(6), 347-356 (1988-01-01)

Reports on fatal benzyl alcohol poisoning in premature neonates implied that the toxicity may be due to larger doses per kilogram than for adults. It has been postulated that the load of benzoic acid (metabolite of benzyl alcohol) may exceed

Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury.

Y Zhu et al.

Neurobiology of disease, 74, 114-125 (2014-12-03)

Spinal cord injury (SCI) leads to formation of a fibrotic scar that is inhibitory to axon regeneration. Recent evidence indicates that the fibrotic scar is formed by perivascular fibroblasts, but the mechanism by which they are recruited to the injury

Partition coefficients between human blood or adipose tissue and air for aromatic solvents.

C H Pierce et al.

Scandinavian journal of work, environment & health, 22(2), 112-118 (1996-04-01)

The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition coefficients between blood and air and adipose tissue and air were determined for widely

Effect of benzene, toluene, xylene on the semen quality and the function of accessory gonad of exposed workers.

G Xiao et al.

Industrial health, 39(2), 206-210 (2001-05-09)

The effects on semen and the function of accessory gonad of workers after short and long term exposure to benzene, toluene, and xylene were examined. The semen and blood of 24 married workers exposed to benzene, toluene, and xylene were

Mechanistic borderline of one-step hydrogen atom transfer versus stepwise Sc(3+)-coupled electron transfer from benzyl alcohol derivatives to a non-heme iron(IV)-oxo complex.

Yuma Morimoto et al.

Inorganic chemistry, 51(18), 10025-10036 (2012-09-08)

The rate of oxidation of 2,5-dimethoxybenzyl alcohol (2,5-(MeO)(2)C(6)H(3)CH(2)OH) by [Fe(IV)(O)(N4Py)](2+) (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) was enhanced significantly in the presence of Sc(OTf)(3) (OTf(-) = trifluoromethanesulfonate) in acetonitrile (e.g., 120-fold acceleration in the presence of Sc(3+)). Such a remarkable enhancement of the

Organocatalytic synthesis of quinine-functionalized poly(carbonate)s.

Justin A Edward et al.

Biomacromolecules, 13(8), 2483-2489 (2012-08-02)

The ring-opening polymerization of substituted cyclic carbonates with 1-(3,5-bis-trifluoromethyl-phenyl)-3-cyclohexyl-thiourea (TU)/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) organocatalysts afford highly functionalized oligocarbonates. The fluorescent alkaloid quinine can be readily incorporated into the oligocarbonates either by initiation from quinine or by ring-opening polymerization of a quinine-functionalized cyclic

Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt].

Béatrice Hechler et al.

The Journal of pharmacology and experimental therapeutics, 314(1), 232-243 (2005-03-29)

Our aim was to determine whether the newly described P2X1 antagonist NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt] could selectively antagonize the platelet P2X1 receptor and how it affected platelet function. NF449 inhibited alpha,beta-methyleneadenosine 5'-triphosphate-induced shape change (IC50 = 83 +/- 13

Ciclopirox delivery into the human nail plate using novel lipid diffusion enhancers.

Farhaan Hafeez et al.

Drug development and industrial pharmacy, 40(6), 838-844 (2013-04-23)

Onychomycosis is a common fungal infection of the nail plate and bed that affects up to 14% of the population and can have a substantial impact on the quality of life of those affected. This study compared the onychopharmacokinetics, nail

Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver.

A Salamon et al.

Life sciences, 69(21), 2489-2502 (2001-11-06)

Benzamide riboside (BR) is a novel anticancer agent exhibiting pronounced activity against several human tumor cells, however, little is known about its biotransformation. To analyze for BR and its metabolites, livers of Wistar and mutant TR- rats were perfused with

Assessment of telemetry and fluidic control system used in the Medstream programmable infusion system: an in vivo and in vitro study.

Toralf Bork et al.

Biomedical microdevices, 16(5), 779-792 (2014-07-06)

The MedStream Programmable Infusion Pump, an intrathecal pump indicated for the treatment of chronic intractable pain and severe spasticity (CE-mark) or severe spasticity (US), has a highly accurate medication delivery (within 10% of the programmed flow rate) and is certified

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