201-228-5

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Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit.

L J Schedlich et al.

The Journal of biological chemistry, 275(31), 23462-23470 (2000-05-16)

Although insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 are known to modulate cell growth by reversibly sequestering extracellular insulin-like growth factors, several reports have suggested that IGFBP-3, and possibly also IGFBP-5, have important insulin-like growth factor-independent effects on cell growth.

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