30181

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In vivo confocal microscopic characterisation of the cornea in chronic graft-versus-host disease related severe dry eye disease.

B Steger et al.

The British journal of ophthalmology, 99(2), 160-165 (2014-08-21)

To first describe in vivo confocal microscopic (IVCM) corneal findings in severe dry eye syndrome due to ocular chronic graft versus host disease (cGvHD) after allogeneic stem cell transplantation. IVCM of the central cornea was performed in 12 prospectively recruited

Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye.

Bin-wu Lin et al.

Investigative ophthalmology & visual science, 56(1), 45-53 (2014-12-11)

To investigate the effect of FK-506 eye drops on Botulinum toxin B (BTX-B)-induced mouse dry eye. Forty-five CBA/J mice were followed up for 4 weeks after treatment with 0.025% FK-506, vehicle or 0.9% saline eye drops 3 days after intralacrimal

Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1.

Ha-Young Park et al.

Bioscience, biotechnology, and biochemistry, 79(1), 130-137 (2014-09-02)

We investigated the effect of theaflavins (TFs) on membrane barrier of Caco-2 cells. For fluorescein-transport experiments, the apparent permeability (Papp) of fluorescein in Caco-2 cells pretreated with 20 μM TFs were significantly decreased compared with that in untreated cells. Although the

The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain.

Ran Ran et al.

Acta neurobiologiae experimentalis, 74(4), 405-414 (2015-01-13)

We aim to investigate the changes of The γ-aminobutyric acid (GABA) signals in the adjacent intact dorsal root ganglion (DRG) and the contribution of these changes to the development and maintenance of neuropathic pain (NPP). After establishment of neuropathic pain

Phenotypic evolution of therapeutic Salmonella enterica serovar Typhimurium after invasion of TRAMP mouse prostate tumor.

Elizabeth Choe et al.

mBio, 5(4), e01182-e01114 (2014-07-06)

Salmonella has been of interest in cancer research due to its intrinsic ability to selectively target and colonize within tumors, leading to tumor cell death. Current research indicates promising use of Salmonella in regular administrations to remove tumors in mouse

Fluorescein angiography and optical coherence tomography in myopic choroidal neovascularization.

J Chhablani et al.

Eye (London, England), 29(4), 519-524 (2015-01-24)

To assess intra/inter-observer agreement, and diagnostic capabilities of a color fundus photograph, fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) in making a diagnosis of myopic choroidal neovascularization (CNV). Two masked observers evaluated FFA and SD-OCT images

Tear exchangeable limbal rigid contact lens for ocular sequelae resulting from Stevens-Johnson syndrome or toxic epidermal necrolysis.

Chie Sotozono et al.

American journal of ophthalmology, 158(5), 983-993 (2014-07-19)

To evaluate the therapeutic benefits of tear-exchangeable, limbal, rigid contact lenses (limbal CLs) in patients with Stevens-Johnson syndrome- or toxic epidermal necrolysis-associated ocular sequelae. Noncomparative, retrospective, interventional case series. We enrolled 53 eyes of 42 patients (mean age, 51.8 ±

In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.

Mouming Zhao et al.

Journal of agricultural and food chemistry, 62(31), 7771-7778 (2014-07-17)

This study aimed to explore the potential of polished adlay, brown adlay, adlay bran, and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats. Free and bound phenolic

Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver.

Jennifer C Ryan et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1488-R1492 (2014-10-24)

Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However

Method for the analysis of phloxine B, uranine, and related xanthene dyes in soil using supercritical fluid extraction and high-performance liquid chromatography

Alcantara-Licudine PJ, et al.

Journal of Agricultural and Food Chemistry, 45(3), 766-773 (1997)

Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.

Abbie Chapman Johnson et al.

PloS one, 9(11), e113670-e113670 (2014-11-20)

Eclampsia, defined as unexplained seizure in a woman with preeclampsia, is a life-threatening complication of pregnancy with unclear etiology. Magnesium sulfate (MgSO4) is the leading eclamptic seizure prophylactic, yet its mechanism of action remains unclear. Here, we hypothesized severe preeclampsia

Infrared imaging of meibomian glands and evaluation of the lipid layer in Sjögren's syndrome patients and nondry eye controls.

Kara L Menzies et al.

Investigative ophthalmology & visual science, 56(2), 836-841 (2015-01-13)

The purpose of this study was to evaluate meibomian gland dropout and lipid layer thickness (LLT) in patients with and without Sjögren's syndrome dry eye (SS). We recruited 11 participants with SS (males/females [M/F], 1:10; mean age = 56.0 ±

Highly reduced ecotoxicity of ZnO-based micro/nanostructures on aquatic biota: Influence of architecture, chemical composition, fixation, and photocatalytic efficiency

Serra A, et al.

Water Research, 169(9), 115210-115210 (2020)

Enteric-coating of pulsatile-release HPC capsules prepared by injection molding.

E Macchi et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 1-11 (2015-01-15)

Capsular devices based on hydroxypropyl cellulose (Klucel® LF) intended for pulsatile release were prepared by injection molding (IM). In the present work, the possibility of exploiting such capsules for the development of colonic delivery systems based on a time-dependent approach

Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography-tandem mass spectrometry.

Yanmei Zhang et al.

Journal of chromatography. A, 1388, 267-273 (2015-03-03)

In this study, capillary electrophoresis (CE) combined with HPLC-MS/MS were used as a powerful platform for screening of inhibitors of mammalian target of rapamycin (mTOR) in natural product extracts. The screening system has been established by using 5-carboxyfluorescein labeled substrate

Temporal effects of vascular endothelial growth factor and 3,5-cyclic monophosphate on blood-brain barrier solute permeability in vivo.

Lingyan Shi et al.

Journal of neuroscience research, 92(12), 1678-1689 (2014-07-30)

To test the hypothesis that vascular endothelial growth factor (VEGF) can transiently increase the blood-brain barrier permeability, P, as for peripheral microvessels and that the elevation of 3,5-cyclic monophosphate (cAMP) levels can inhibit the VEGF-induced acute hyperpermeability, we employed multiphoton

One rhinophore probably provides sufficient sensory input for odour-based navigation by the nudibranch mollusc Tritonia diomedea.

Gregory B McCullagh et al.

The Journal of experimental biology, 217(Pt 23), 4149-4158 (2014-10-18)

Tritonia diomedea (synonymous with Tritonia tetraquetra) navigates in turbulent odour plumes, crawling upstream towards prey and downstream to avoid predators. This is probably accomplished by odour-gated rheotaxis, but other possibilities have not been excluded. Our goal was to test whether

Identification of phenolic compounds in petals of nasturtium flowers (Tropaeolum majus) by high-performance liquid chromatography coupled to mass spectrometry and determination of oxygen radical absorbance capacity (ORAC).

G Astrid Garzón et al.

Journal of agricultural and food chemistry, 63(6), 1803-1811 (2015-02-11)

The contents and profile of polyphenols were analyzed in edible petals of nasturtium flowers (Tropaeolum majus) of three colors, and their oxygen radical absorbance capacities (ORAC) were compared. Three primary anthocyanins (ACNs) and 15 non-ACN phenolic compounds including hydroxycinammic acids

One-pot synthesis of antibacterial monomers with dual biocidal modes.

Wei Zhang et al.

Journal of dentistry, 42(9), 1078-1095 (2014-06-17)

The present study reported a method for preparing a blend of antibacterial quaternary ammonium silanes and quaternary ammonium methacryloxy silane (QAMS) based on the sol-gel reaction between dimethyldiethoxy silane and two trialkoxysilanes, one with an antibacterial quaternary ammonium functionality and

Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.

Mehrnaz Nouri et al.

PloS one, 9(9), e106335-e106335 (2014-09-04)

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a pathogenesis involving a dysfunctional blood-brain barrier and myelin-specific, autoreactive T cells. Although the commensal microbiota seems to affect its pathogenesis, regulation of the interactions

Absorption and desorption behaviour of the flavonoids from Glycyrrhiza glabra L. leaf on macroporous adsorption resins.

Yi Dong et al.

Food chemistry, 168, 538-545 (2014-08-31)

The kinetics of adsorption and desorption behaviours of five macroporous resins for enriching flavonoids from Glycyrrhizaglabra L. leaf were investigated. All five resins showed similar and effective adsorption and desorption properties. A pseudo-second-order kinetics model was suitable for evaluating the

Deoxycholic acid induced changes in electrophysiological parameters and macromolecular permeability in murine small intestine with and without functional enteric nervous system plexuses.

R A Forsgård et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(8), 1179-1187 (2014-06-24)

We have previously shown in mice that the fecal proportion and concentration of the hydrophobic bile acid deoxycholic acid (DCA) is elevated with high-fat feeding and that these changes are able to disrupt the intestinal barrier function. The aim of

Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition.

Camilla A Thorling et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(1), 154-162 (2014-11-09)

Ischemia-reperfusion injury, a common complication during liver surgery where steatotic livers are more prone to the injury, may become more prevalent in the growing obese population. This study characterizes liver morphology toward understanding changes in subcellular function in steatotic livers

Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans.

Susan J Zunino et al.

The British journal of nutrition, 112(3), 369-380 (2014-05-17)

Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60

Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging.

Chenying Yang et al.

Journal of biomedical optics, 19(7), 76014-76014 (2014-07-17)

Fluorescence molecular imaging with exogenous probes improves specificity for the detection of diseased tissues by targeting unambiguous molecular signatures. Additionally, increased diagnostic sensitivity is expected with the application of multiple molecular probes. We developed a real-time multispectral fluorescence-reflectance scanning fiber

Plant regeneration and biochemical accumulation of hydroxybenzoic and hydroxycinnamic acid derivatives in Hypoxis hemerocallidea organ and callus cultures.

Mack Moyo et al.

Plant science : an international journal of experimental plant biology, 227, 157-164 (2014-09-16)

Micropropagation of Hypoxis hemerocallidea Fisch. and C.A. Mey was used as a model system to study the influence of cytokinins (CKs) on plant regeneration and biochemical accumulation of hydroxybenzoic and hydroxycinnamic acid derivatives in organ and callus cultures and their

Solid-phase extraction (SPE) of the fluorescence tracers uranine and sulphorhodamine B

Franke C, et al.

Water Research, 31(10), 2633-2637 (1997)

Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination.

Caroline M Lai et al.

The Journal of infectious diseases, 211(3), 383-393 (2014-08-26)

Viruses that cause systemic disease often spread through the bloodstream to infect target tissues. Although viremia is an important step in the pathogenesis of many viruses, how viremia is established is not well understood. Reovirus has been used to dissect

Effect of downscaling on the linearity range of a calibration curve in spectrofluorimetry.

Radoslaw Kwapiszewski et al.

Analytical and bioanalytical chemistry, 406(18), 4551-4556 (2014-05-13)

Interest in the microfluidic environment, owing to its unique physical properties, is increasing in much innovative chemical, biological, or medicinal research. The possibility of exploiting and using new phenomena makes the microscale a powerful tool to improve currently used macroscopic

Characterisation of microbial activity in the framework of natural attenuation without groundwater monitoring wells?: a new Direct-Push probe.

Christian Schurig et al.

Environmental science and pollution research international, 21(15), 9002-9015 (2013-04-17)

At many contaminated field sites in Europe, monitored natural attenuation is a feasible site remediation option. Natural attenuation includes several processes but only the microbial degradation leads to real contaminant removal and very few methods are accepted by the authorities

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