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Jelena Levi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(14), 3721-3729 (2014-05-23)
To evaluate the utility of targeted photoacoustic imaging (PAI) in providing molecular information to complement intrinsic functional and anatomical details of the vasculature within prostate lesion. We developed a PAI agent, AA3G-740, that targets gastrin-releasing peptide receptor (GRPR), found to
Kathrin Buchholz et al.
Antimicrobial agents and chemotherapy, 52(1), 183-191 (2007-10-31)
Methylene blue (MB) has experienced a renaissance mainly as a component of drug combinations against Plasmodium falciparum malaria. Here, we report biochemically relevant pharmacological data on MB such as rate constants for the uncatalyzed reaction of MB at pH 7.4
Xianlong Zhang et al.
Journal of environmental sciences (China), 33, 97-105 (2015-07-05)
An activation process for developing the surface and porous structure of palygorskite/carbon (PG/C) nanocomposite using ZnCl2 as activating agent was investigated. The obtained activated PG/C was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy
Ahmed Ebraheem Al Subaie et al.
Journal of clinical periodontology, 42(7), 688-696 (2015-06-16)
To assess the effect of anti-vascular endothelial growth factors (VEGF) on bone healing (defect volume) and implant osseointegration (bone-implant contact per cent) in rat tibia. In Sprague-Dawley rats (n = 36), a unicortical defect was created in the right tibia
Chang Hee Woo et al.
Journal of biomaterials science. Polymer edition, 26(13), 841-854 (2015-06-23)
We designed bilayer composites composed of an upper layer of titanium dioxide (TiO2)-incorporated chitosan membrane and a sub-layer of human adipose-derived extracellular matrix (ECM) sheet as a wound dressing for full-thickness wound healing. The dense and fibrous top layer, which
Wolfgang Friebolin et al.
Journal of medicinal chemistry, 51(5), 1260-1277 (2008-02-12)
Plasmodium parasites are exposed to higher fluxes of reactive oxygen species and need high activities of intracellular antioxidant systems providing a steady glutathione flux. As a future generation of dual drugs, 18 naphthoquinones and phenols (or their reduced forms) containing
Ashok A Kumar et al.
American journal of hematology, 90(1), 31-36 (2014-09-30)
This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)-immiscible phases of solutions of polymers that form step-gradients in density. The interfaces of an AMPS concentrate cells; this concentration facilitates the extraction of blood
Bo-Kuan Wu et al.
Cell cycle (Georgetown, Tex.), 13(20), 3222-3231 (2014-12-09)
Site-specific hypermethylation of tumor suppressor genes accompanied by genome-wide hypomethylation are epigenetic hallmarks of malignancy. However, the molecular mechanisms that drive these linked changes in DNA methylation remain obscure. DNA methyltransferase 1 (DNMT1), the principle enzyme responsible for maintaining methylation
Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation.
Ivonne Brüstle et al.
Beilstein journal of nanotechnology, 6, 383-395 (2015-03-31)
The combination of stem cell therapy and nanoparticles promises to enhance the effect of cellular therapies by using nanocarriers as drug delivery devices to guide the further differentiation or homing of stem cells. The impact of nanoparticles on primary cell
Takayuki Uematsu et al.
Scientific reports, 5, 17577-17577 (2015-12-03)
Influenza virus (IFV) infection is a common cause of severe viral pneumonia associated with acute respiratory distress syndrome (ARDS), which is difficult to control with general immunosuppressive therapy including corticosteroids due to the unfavorable effect on viral replication. Studies have
Nicholas J D Wright et al.
Invertebrate neuroscience : IN, 15(1), 175-175 (2014-11-09)
The generation of the novel messenger molecule nitric oxide (NO) has been demonstrated in many tissues across phyla including nervous systems. It is produced on demand by the enzyme nitric oxide synthase often stimulated by intracellular calcium and typically affecting
Edward Chang et al.
Journal of medicinal chemistry, 52(11), 3539-3547 (2009-05-13)
A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents. One potent member of the series
J Calvez et al.
Genes, brain, and behavior, 14(7), 550-563 (2015-08-04)
Relaxin-3 (RLN3) is an orexigenic neuropeptide that produces sex-specific effects on food intake by stronger stimulation of feeding in female compared with male rats. This study determined which hypothalamic nuclei and associated neuropeptides may be involved in the sex-specific orexigenic
Yuko Mitobe et al.
Regulatory toxicology and pharmacology : RTP, 71(3), 529-540 (2015-02-24)
Japanese cedar (JC) pollinosis is caused by Japanese cedar pollen (JCP) and most common seasonal allergic disease in Japan. Subcutaneous immunotherapy (SCIT) with allergen extract of JCP (JCP-allergen extract) is well established for JC pollinosis treatment with improvement of symptoms.
D C Riley et al.
Journal of neuroscience research, 93(4), 572-583 (2014-11-27)
Restoration of neuronal functions by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all, especially after ablation of nerve segments. Distal segments of severed axons typically
Hung-Wen Lai et al.
Surgical innovation, 22(4), 382-389 (2014-08-15)
Endoscopy-assisted breast surgery performed through minimal axillary and/or periareolar incisions is a viable option for patients with breast cancer. In this study, we report the preliminary results of patients with breast cancer who underwent endoscopy-assisted total mastectomy (EATM) followed immediately
Xiaoqiang Cong et al.
Molecular medicine reports, 9(6), 2528-2532 (2014-04-01)
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor-α (TNF-α) induction in an ischemia/reperfusion-injured rat heart model.
Catherine Kamtchueng et al.
PloS one, 9(7), e102399-e102399 (2014-07-16)
The TAF6δ pathway of apoptosis can dictate life versus death decisions independently of the status of p53 tumor suppressor. TAF6δ is an inducible pro-apoptotic subunit of the general RNA polymerase II (Pol II) transcription factor TFIID. Alternative splice site choice
N Waldschmitt et al.
Mucosal immunology, 7(6), 1452-1466 (2014-05-23)
Loss of intestinal epithelial cell (IEC) homeostasis and apoptosis negatively affect intestinal barrier function. Uncontrolled activation of the unfolded protein response (UPR) in IEC contributes to an impaired barrier and is implicated in the pathogenesis of inflammatory bowel diseases. However
Allison Auchter et al.
Journal of Alzheimer's disease : JAD, 42 Suppl 4, S525-S535 (2014-08-01)
Chronic cerebral hypoperfusion, a risk factor for mild cognitive impairment and Alzheimer's disease, affects mitochondrial respiration and memory consolidation. Therefore, drugs that improve mitochondrial function may be appropriate cognitive treatments for cerebral hypoperfusion. Methylene blue (MB) crosses the blood-brain barrier
Shengjie Xia et al.
Physical chemistry chemical physics : PCCP, 17(7), 5345-5351 (2015-01-23)
Three different composites, including a calcined FeOOH supported ZnAl layered double hydroxide (FeOOH-LDO), a calcined ZnAl layered double hydroxide (ZnAl-LDO) and a calcined ZnFeAl layered double hydroxide (ZnFeAl-LDO), were synthesized via a sol-gel method, and their activity for the visible
Regina Lohmayer et al.
Analytical chemistry, 87(6), 3388-3395 (2015-02-25)
Molybdenum precipitates preferentially under reducing conditions; therefore, its occurrence in sediment records is used as an indicator of paleoredox conditions. Although thiomolybdates (MoO4-xSx(2-) with x = 1-4) supposedly are necessary intermediates in the process of molybdenum precipitation under anoxic conditions
Ben Aernouts et al.
Optics express, 23(20), 26049-26063 (2015-10-21)
In many research areas and application domains, the bulk optical properties of biological materials are of great interest. Unfortunately, these properties cannot be obtained easily for complex turbid media. In this study, a metamodeling approach has been proposed and applied
Swati Mishra et al.
Journal of biomedical materials research. Part A, 103(10), 3237-3249 (2015-03-18)
Three-dimensional (3D) patterning and engineering of biomaterials and biointerfaces have helped bioengineers harness the full potential of cell immobilization for different biomedical applications. However, the bioengineering of an efficient cell immobilized tool, having application in cell biology and tissue engineering
Alexandru Grigoroiu et al.
Scientific reports, 10(1), 3947-3947 (2020-03-05)
Hyperspectral imaging (HSI) is being explored in endoscopy as a tool to extract biochemical information that may improve contrast for early cancer detection in the gastrointestinal tract. Motion artefacts during medical endoscopy have traditionally limited HSI application, however, recent developments
Bassam M Al Meslmani et al.
Materials science & engineering. C, Materials for biological applications, 58, 78-87 (2015-10-20)
Graft-associated infections entirely determine the short-term patency of polyethylene terephthalate PET cardiovascular graft. We attempted to enzymatically inhibit the initial bacterial adhesion to PET grafts using lysozyme. Lysozyme was covalently immobilized onto woven and knitted forms of crimped PET grafts
Cécile Voisset et al.
Disease models & mechanisms, 7(4), 435-444 (2014-02-22)
Epstein-Barr virus (EBV) is tightly associated with certain human cancers, but there is as yet no specific treatment against EBV-related diseases. The EBV-encoded EBNA1 protein is essential to maintain viral episomes and for viral persistence. As such, EBNA1 is expressed
Xiaole Zhang et al.
Journal of colloid and interface science, 448, 189-196 (2015-03-04)
In this work, a facile one-pot strategy was proposed for the synthesis of C18-functionalized core-shell magnetic mesoporous silica composite (Fe3O4/mSiO2-C18). The Fe3O4/mSiO2-C18 composite, with an average size of 80 nm and a functionalized mesoporous silica shell of about 30 nm
Kimberly N Herman et al.
Journal of biochemical and molecular toxicology, 28(12), 568-577 (2014-08-29)
Elevated levels of reactive oxygen species (ROS) can be induced by exposure to various chemicals and radiation. One type of damage in DNA produced by ROS is modification of guanine to 7,8-dihydro-8-oxoguanine (8-oxoG). This particular alteration to the chemistry of
Gustavo A Higuera et al.
Biomaterials, 61, 190-202 (2015-05-26)
Cells and tissues are intrinsically adapted to molecular gradients and use them to maintain or change their activity. The effect of such gradients is particularly important for cell populations that have an intrinsic capacity to differentiate into multiple cell lineages
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