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C R Bourne et al.
Antimicrobial agents and chemotherapy, 54(9), 3825-3833 (2010-07-08)
The bacterial burden on human health is quickly outweighing available therapeutics. Our long-term goal is the development of antimicrobials with the potential for broad-spectrum activity. We previously reported phthalazine-based inhibitors of dihydrofolate reductase (DHFR) with potent activity against Bacillus anthracis
Brenda Edith Chacon-Moreno et al.
Antimicrobial agents and chemotherapy, 53(1), 295-297 (2008-10-15)
The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole
Yoshifumi Ikee et al.
Bioorganic & medicinal chemistry letters, 17(4), 942-945 (2006-12-13)
The ring-opening reactions of 1-azabicyclo[1.1.0]butane 3 with thiols 6a-f gave 3-sulfenylazetidine derivatives 7a-f in 50-92% yields. Treatment of 3 with aromatic amines 11a-e and dibenzylamine 11f in the presence of Mg(ClO(4))(2) afforded the corresponding 3-aminoazetidine derivatives 12a-f in 24-53% yields.
Son T Nguyen et al.
Bioorganic & medicinal chemistry letters, 21(19), 5961-5963 (2011-08-26)
Decarboxylated ciprofloxacin (3) has been reported in the literature to have antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus subtilis, Enterobacter cloacae, Serratia marcescens and especially potent activity against Escherichia coli. Herein, we report our syntheses of 3
Bruno Périchon et al.
Antimicrobial agents and chemotherapy, 51(7), 2464-2469 (2007-05-02)
Plasmid pIP1206 was detected in Escherichia coli strain 1540 during the screening of clinical isolates of Enterobacteriaceae for high-level resistance to aminoglycosides. The sequence of this IncFI conjugative plasmid of ca. 100 kb was partially determined. pIP1206 carried the rmtB
Ping Shen et al.
Antimicrobial agents and chemotherapy, 53(10), 4333-4338 (2009-07-22)
Thirty-nine bla(KPC)-producing isolates of the family Enterobacteriaceae with carbapenem resistance or reduced carbapenem susceptibility were obtained from inpatients from eight hospitals in six cities of three provinces in eastern China. The pulsed-field gel electrophoresis analysis of all 36 Klebsiella pneumoniae
Esther Julián et al.
PloS one, 10(3), e0122049-e0122049 (2015-03-18)
The emergence of multidrug-resistant bacteria has encouraged vigorous efforts to develop antimicrobial agents with new mechanisms of action. Ribonucleotide reductase (RNR) is a key enzyme in DNA replication that acts by converting ribonucleotides into the corresponding deoxyribonucleotides, which are the
Anton Y Peleg et al.
Antimicrobial agents and chemotherapy, 51(6), 2065-2069 (2007-04-11)
Tigecycline has an extended spectrum of in vitro antimicrobial activities, including that against multidrug-resistant Acinetobacter. After identifying bloodstream isolates of Acinetobacter with reduced susceptibilities to tigecycline, we performed a study to assess tigecycline efflux mediated by the resistance-nodulation-division-type transporter AdeABC.
Volodymyr Samoylenko et al.
Journal of natural products, 72(1), 92-98 (2008-12-25)
A new potent antiinfective and antiparasitic 2,3-dihydro-1H-indolizinium chloride (1) was isolated from Prosopis glandulosa var. glandulosa. Three additional new (2-4) and one known (5) indolizidines were also isolated, and the dihydrochloride salts of 1-3 (compounds 6, 7, and 8) were
Anna Fàbrega et al.
Antimicrobial agents and chemotherapy, 54(3), 1218-1225 (2009-12-17)
Elevated levels of fluoroquinolone resistance are frequently found among Escherichia coli clinical isolates. This study investigated the antibiotic resistance mechanisms of strain NorE5, derived in vitro by exposing an E. coli clinical isolate, PS5, to two selection steps with increasing
Eliane Garo et al.
Antimicrobial agents and chemotherapy, 51(5), 1813-1817 (2007-03-14)
Asiatic acid and corosolic acid are two natural products identified as biofilm inhibitors in a biofilm inhibition assay. We evaluated the activities of these two compounds on Pseudomonas aeruginosa biofilms grown in rotating disk reactors (RDRs) in combination with tobramycin
C Juan et al.
Antimicrobial agents and chemotherapy, 53(12), 5288-5290 (2009-09-23)
Two clonally related Pseudomonas aeruginosa isolates, recovered from two patients admitted to a pediatric intensive care unit, were found to harbor a new OXA-2 variant (Asn148Asp), designated OXA-161. The plasmid location of bla(OXA-161) was demonstrated through electroporation to PAO1, and
Azadeh Rahmani-Badi et al.
Journal of medical microbiology, 63(Pt 11), 1509-1516 (2014-08-02)
The catheterized urinary tract provides ideal conditions for the development of biofilm populations. Catheter-associated urinary tract infections (CAUTIs) are recalcitrant to existing antimicrobial treatments; therefore, established biofilms are not eradicated completely after treatment and surviving biofilm cells will carry on
Kathy Smith et al.
Antimicrobial agents and chemotherapy, 52(6), 2279-2282 (2008-03-26)
Against 300 strains of pneumococci and 100 group A streptococci of differing beta-lactam, macrolide, and quinolone resistance phenotypes, AR-709 was very active, with all MICs being < or =2 microg/ml. Furthermore, AR-709 was active against strains that were both susceptible
Ryoichi Hamasuna et al.
Antimicrobial agents and chemotherapy, 53(11), 4938-4939 (2009-09-10)
Only limited information regarding the antimicrobial susceptibilities of Mycoplasma genitalium is available because of difficulties in isolating M. genitalium strains from clinical specimens. Antimicrobial susceptibilities of 15 clinical isolates, 7 ATCC strains, and an early passage of the M30 strain
Abraham A Wube et al.
Bioorganic & medicinal chemistry, 19(1), 567-579 (2010-11-26)
A series of 23 new 1-methyl-2-alkenyl-4(1H)quinolones have been synthesized and evaluated in vitro for their antimycobacterial activities against fast growing species of mycobacteria, such as Mycobacterium fortuitum, M. smegmatis and M. phlei. The compounds displayed good to excellent inhibition of
Stefano Sabatini et al.
Journal of medicinal chemistry, 54(16), 5722-5736 (2011-07-15)
Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of substrate antimicrobial agents. Inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus efflux pump that confers
Mari Sithambaram Karthikeyan et al.
European journal of medicinal chemistry, 42(1), 30-36 (2006-09-30)
A series of chloro-fluorine containing chalcones (3) were prepared by Claisen-Schmidt condensation. Chalcone dibromides (4) were obtained by the bromination of chalcones at room temperature. Treatment of chalcone dibromides (4) with aryloxy acid hydrazides (5) in the presence of triethylamine
Muhammad Malik et al.
Antimicrobial agents and chemotherapy, 51(1), 28-34 (2006-10-18)
Quinolone activity against Escherichia coli was examined during aerobic growth, aerobic treatment with chloramphenicol, and anaerobic growth. Nalidixic acid, norfloxacin, ciprofloxacin, and PD161144 were lethal for cultures growing aerobically, and the bacteriostatic activity of each quinolone was unaffected by anaerobic
Shanmugam Srinivasan et al.
European journal of medicinal chemistry, 45(12), 6101-6105 (2010-10-12)
A series of 1-ethyl-6,8-difluoro-4-oxo-7(4-aryl piperazin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (6a-f) and 1-ethyl-6,8-difluoro-4-oxo-7(4-piperidin-1-yl) 1,4-dihydro-quinoline-3-carboxylic acid derivatives (7a-e) were synthesized and evaluated for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were
Erik Glocker et al.
Antimicrobial agents and chemotherapy, 51(1), 346-349 (2006-10-18)
We show that quinolone resistance in Helicobacter pylori has reached an alarming level in Germany. Our data suggest that the use of quinolones requires prior antimicrobial susceptibility testing, especially for isolates from patients who have already undergone previous unsuccessful eradication
J Hummelova et al.
Letters in applied microbiology, 60(3), 242-247 (2014-11-26)
In this study, we tested 15 naturally occurring isoflavones and their metabolites for their possible antibacterial properties against nine Gram-positive and Gram-negative bacteria. The in vitro antibacterial activity was determined using the broth microdilution method, and the results were expressed
Mohamed M Radwan et al.
Journal of natural products, 72(5), 906-911 (2009-04-07)
Nine new cannabinoids (1-9) were isolated from a high-potency variety of Cannabis sativa. Their structures were identified as (+/-)-4-acetoxycannabichromene (1), (+/-)-3''-hydroxy-Delta((4'',5''))-cannabichromene (2), (-)-7-hydroxycannabichromane (3), (-)-7R-cannabicoumarononic acid A (4), 5-acetyl-4-hydroxycannabigerol (5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol (6), 8-hydroxycannabinol (7), 8-hydroxycannabinolic acid A (8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone
Kazuko Yamamoto et al.
Antimicrobial agents and chemotherapy, 53(8), 3572-3575 (2009-05-20)
We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater
Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland.
Anna Baraniak et al.
Antimicrobial agents and chemotherapy, 53(10), 4565-4567 (2009-07-22)
Torsten Herzog et al.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, 27(5), 273-281 (2014-05-17)
After pancreatectomy, an isolated bile leak from the hepaticojejunostomy is a severe surgical complication that is underrepresented both, in the literature and in the awareness of pancreatic surgeons. The goal of this study was to analyze the incidence and outcome
Do-Won Jeong et al.
International journal of food microbiology, 188, 108-115 (2014-08-12)
To select starters for jeotgal, a traditional Korean high-salt-fermented seafood, the safety and technological properties of its predominant bacteria isolates, which were identified as Staphylococcus equorum, were assessed. Among the 185 S. equorum isolates from jeotgal, 126 ampicillin-sensitive strains were
Om Prakash et al.
European journal of medicinal chemistry, 46(10), 5065-5073 (2011-09-09)
Two series of compounds namely, dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadizines (9a-l & 11a-l) were synthesized by cyclocondensation between α-bromoindanones (7a-b) or/and α,α-dibromoindanones (8a-b) and various 3-alkyl/aryl-4-amino-5-mercapto-1,2,4-s-triazoles (3a-f) in methanol with an aim to explore their effect on in
Theresa J Ochoa et al.
Antimicrobial agents and chemotherapy, 51(8), 2837-2841 (2007-05-29)
Diarrhea in children is often caused by enteropathogen infections that might benefit from early empirical antibiotic therapy. However, when the definition of the pathogen requires sophisticated laboratory studies, the etiology of enteritis is not known early in illness. Empirical therapy
Perumal Rajakumar et al.
European journal of medicinal chemistry, 46(7), 3093-3098 (2011-04-26)
The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic
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