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Fabiano Oliveira et al.
Science translational medicine, 7(290), 290ra90-290ra90 (2015-06-05)
Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman
Kit-Man Lau et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(7), 942-945 (2014-04-08)
Bakuchiol was an active antifungal compound isolated from Psoraleae Fructus by means of bioassay-guided fractionation in our previous study. The present work aimed to investigate the underlying mechanisms and the therapeutic effect of bakuchiol in Trichophyton mentagrophytes-induced tinea pedis. After
Małgorzata Gumułka et al.
Animal reproduction science, 154, 166-175 (2015-01-21)
In flocks of geese fertility decreases in the second half of the breeding season. The reasons for this reduction in reproduction ability are still unclear. This study measured changes in semen quality variables throughout the period of intensive breeding in
Karine Rech Begnini et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 639856-639856 (2014-12-23)
Natural products continue to be an invaluable resource of anticancer drug discovery in recent years. Propolis is known for its biological activities such as antimicrobial and antitumor effects. This study assessed the effects of Brazilian red propolis (BRP) on apoptosis
Chorom Pak et al.
Integrative biology : quantitative biosciences from nano to macro, 7(6), 643-654 (2015-05-23)
Chemosensitivity and resistance assays (CSRAs) aim to direct therapies based upon ex vivo responses of patient tumor cells to chemotherapeutic drugs. However, successful CSRAs are yet to be developed. Here, we exposed primary CD138(+) multiple myeloma (MM) cells to bortezomib
Ana Sofia Rodrigues et al.
PloS one, 10(7), e0131663-e0131663 (2015-07-07)
The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH. For proper complex regulation the E1-α subunit functions as an on/off switch regulated by phosphorylation/dephosphorylation. In different cell types
Interaction between Hanseniaspora uvarum and Saccharomyces cerevisiae during alcoholic fermentation.
Chunxiao Wang et al.
International journal of food microbiology, 206, 67-74 (2015-05-10)
During wine fermentation, Saccharomyces clearly dominate over non-Saccharomyces wine yeasts, and several factors could be related to this dominance. However, the main factor causing the reduction of cultivable non-Saccharomyces populations has not yet been fully established. In the present study
Balázs Kakasi et al.
Acta veterinaria Hungarica, 63(1), 118-124 (2015-02-07)
The aberrations of sperm DNA may cause various problems and have negative consequences on fertility. These influence embryonic development or might lead to early embryo loss. Sperm Chromatin Structure Assay (SCSA) is the flow cytometric method most often used for
Victor Y L Leung et al.
Stem cells (Dayton, Ohio), 32(8), 2164-2177 (2014-04-17)
Intervertebral disc degeneration is associated with back pain and radiculopathy which, being a leading cause of disability, seriously affects the quality of life and presents a hefty burden to society. There is no effective intervention for the disease and the
Stacie M Gutowski et al.
Biomaterials, 44, 55-70 (2015-01-27)
Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement disorders. Chronically implanted neural electrodes induce an unfavorable tissue response which includes inflammation, scar formation, and neuronal cell death, eventually
Jian Yan et al.
Vaccine, 32(24), 2833-2842 (2014-03-19)
Despite an intensive vaccine program influenza infections remain a major health problem, due to the viruses' ability to change its envelope glycoprotein hemagglutinin (HA), through shift and drift, permitting influenza to escape protection induced by current vaccines or natural immunity.
Elisabeth Pinart et al.
Theriogenology, 83(9), 1428-1437 (2015-03-23)
The present approach was designed to evaluate the extender effects on sperm quality and fertility of short-term refrigerated seminal doses from Landrace boars lodged in husbandry-controlled conditions. For this purpose, we analyzed the sperm quality of seminal doses diluted in
Rossella Melchiotti et al.
BMC medical genetics, 15, 73-73 (2014-06-28)
Extracellular ATP is a pro-inflammatory molecule released by damaged cells. Regulatory T cells (Treg) can suppress inflammation by hydrolysing this molecule via ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also termed as CD39. Multiple studies have reported differences in CD39+ Treg percentages
Ariel Finkielsztein et al.
Immunology letters, 163(1), 84-95 (2014-12-03)
Platelets, like stromal cells, present antigen only via MHC class I, but the immune potential of their progenitors has not been explored in humans. We derived CD34(+)CD117(+)CD41(+)CD151(+) megakaryocyte progenitors (MKp) in vitro from mobilized peripheral blood hematopoietic stem and progenitor
Yoon Shin Park et al.
Biomaterials, 65, 140-152 (2015-07-15)
Parathyroid cells release parathyroid hormone (PTH), which controls calcium homeostasis. Loss of parathyroid cells results in hypoparathyroidism and consequent low-turnover bone disease. Here, we investigated whether our recently-established human tonsil-derived mesenchymal stem cells (TMSC) restore in vivo parathyroid cell function in
Monika Fraczek et al.
Journal of assisted reproduction and genetics, 32(5), 771-779 (2015-03-27)
To evaluate whether ejaculated human spermatozoa undergo complete apoptosis or necrosis during experimental semen bacterial infection in vitro. Apoptotic markers, including mitochondrial transmembrane potential (ΔΨm), phosphatidylserine (PS) externalization, and DNA fragmentation, have been detected simultaneously in ejaculated human sperm after
Pierre-Alexandre Bart et al.
The Journal of clinical investigation, 124(11), 4843-4856 (2014-10-02)
BACKGROUND. Vector prime-boost immunization strategies induce strong cellular and humoral immune responses. We examined the priming dose and administration order of heterologous vectors in HIV Vaccine Trials Network 078 (HVTN 078), a randomized, double-blind phase Ib clinical trial to evaluate
Lydia R Durant et al.
European journal of immunology, 44(8), 2340-2348 (2014-04-30)
During respiratory syncytial virus (RSV) infection CD8(+) T cells both assist in viral clearance and contribute to immunopathology. CD8(+) T cells recognize viral peptides presented by dendritic cells (DCs), which can directly present viral antigens when infected or, alternatively, "cross-present"
Victoria Leszczak et al.
ACS applied materials & interfaces, 6(12), 9328-9337 (2014-05-29)
In the design of scaffolds for tissue engineering biochemical function and nanoscale features are of particular interest. Natural polymers provide a wealth of biochemical function, but do not have the processability of synthetic polymers, limiting their ability to mimic the
Zhiling Zhang et al.
Journal of neural engineering, 12(4), 046015-046015 (2015-06-09)
Infection, inflammation, and neuronal loss are common issues that seriously affect the functionality and longevity of chronically implanted neural prostheses. Minocycline hydrochloride (MH) is a broad-spectrum antibiotic and effective anti-inflammatory drug that also exhibits potent neuroprotective activities. In this study
Brian P Hermann et al.
Biology of reproduction, 92(2), 54-54 (2015-01-09)
Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial stem cells arise from morphologically homogeneous prospermatogonia, but growing evidence suggests that only a subset of prospermatogonia develops into the foundational SSC
Robert F Kudernatsch et al.
European journal of immunology, 44(12), 3532-3542 (2014-09-19)
Even today it is still not completely understood how CD8(+) T-cell memory is maintained long term. Since bone marrow (BM) is a niche for immunological memory, we sought to identify long-lasting early memory CD8(+) T cells in this compartment. To
Jochen A Ackermann et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4650-4656 (2015-04-12)
Signals from the BCR are required for Ag-specific B cell recruitment into the immune response. Binding of Ag to the BCR induces phosphorylation of immune receptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling subunits
Yang Wang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(37), 11826-11834 (2014-08-01)
The monodispersed spindle-like polypyrrole hollow nanocapsules (PPy HNCs) as the multifunctional platforms for combining chemotherapy with photothermal therapy for cancer cells are reported. Whereas the hollow cavity of nanocapsules can be used to load the anticancer drug (i.e., doxorubicin) for
Elisabeth Kleppa et al.
PloS one, 9(6), e98593-e98593 (2014-06-05)
Schistosoma haematobium is a waterborne parasite that may cause female genital schistosomiasis (FGS), characterized by genital mucosal lesions. There is clinical and epidemiological evidence for a relationship between FGS and HIV. We investigated the impact of FGS on HIV target
Kyle L O'Hagan et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5272-5284 (2015-11-01)
NKT cells constitute a small population of T cells developed in the thymus that produce large amounts of cytokines and chemokines in response to lipid Ags. Signaling through the Vα14-Jα18 TCR instructs commitment to the NKT cell lineage, but the
Nathan R Schiele et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(6), 874-881 (2015-02-28)
Tendon injuries are common and heal poorly. Strategies to regenerate or replace injured tendons are challenged by an incomplete understanding of normal tendon development. Our previous study showed that embryonic tendon elastic modulus increases as a function of developmental stage.
Joanne Yh Lim et al.
Oncoimmunology, 3, e29028-e29028 (2014-08-02)
Conceptually, the immune system may profoundly influence the efficacy of radiation therapy. Compelling evidence has recently emerged revealing the capacity of local radiation therapy (RT) to induce antitumor immune responses and sparked interest in combining RT with immunotherapy to promote
R Delatolla et al.
Chemosphere, 136, 190-197 (2015-05-24)
The goal of this study was to investigate the potential of biofiltration to reduce the formation potential of disinfection byproducts (DBPs). Particularly, the work investigates the effect of the duration of the filter cycle on the formation potential of total
Muhammad Suhaeri et al.
Tissue engineering. Part A, 21(11-12), 1940-1951 (2015-04-04)
Extracellular matrices (ECM) obtained from in vitro-cultured cells have been given much attention, but its application in cardiac tissue engineering is still limited. This study investigates cardiomyogenic potential of fibroblast-derived matrix (FDM) as a novel ECM platform over gelatin or
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