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Irena Loryan et al.
Pharmaceutical research, 31(8), 2203-2219 (2014-03-14)
The current project was undertaken with the aim to propose and test an in-depth integrative analysis of neuropharmacokinetic (neuroPK) properties of new chemical entities (NCEs), thereby optimizing the routine of evaluation and selection of novel neurotherapeutics. Forty compounds covering a
Petr Kubáň et al.
Journal of chromatography. A, 1281, 142-147 (2013-02-20)
A new method for rapid, direct determination of formate in blood serum samples by capillary electrophoresis with contactless conductometric detection is presented. A selective separation of formate was achieved in approximately 1 min using an electrolyte system comprising 10 mM
Maria Shabbir et al.
PloS one, 10(3), e0119859-e0119859 (2015-03-24)
Prostate cancer is a leading of cause of cancer related death in men. Despite intensive investment in improving early diagnosis, it often escapes timely detection. Mortality remains high in advanced stage prostate cancer where palliative care remains the only option.
W Miklos et al.
Cancer letters, 361(1), 112-120 (2015-03-10)
Although triapine is promising for treatment of advanced leukemia, it failed against solid tumors due to widely unknown reasons. To address this issue, a new triapine-resistant cell line (SW480/tria) was generated by drug selection and investigated in this study. Notably
Wen Tang et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(6), 505-508 (2014-08-01)
To investigate phospholipids (PLs) biomarkers in predicting outcome of patients undergoing peritoneal dialysis (PD). Twenty PD patients were followed using baseline plasma PLs with an improved online two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry system. Significant differences were observed in eight
Alok Kumar Singh et al.
Infection and immunity, 83(5), 1853-1868 (2015-02-19)
Leishmania donovani, a protozoan parasite, is the causative agent of visceral leishmaniasis. It lives and multiplies within the harsh environment of macrophages. In order to investigate how intracellular parasite manipulate the host cell environment, we undertook a quantitative proteomic study
Zhixiang Wu et al.
Molecular & cellular proteomics : MCP, 14(2), 329-339 (2014-12-17)
Methylation of lysine residues on histone proteins is known to play an important role in chromatin structure and function. However, non-histone protein substrates of this modification remain largely unknown. An effective approach for system-wide analysis of protein lysine methylation, particularly
Mina Mirzaian et al.
Journal of lipid research, 56(4), 936-943 (2015-01-30)
Sulfatides are found in brain as components of myelin, oligodendrocytes, and neurons but are also present in various visceral tissues. Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder caused by a deficiency of arylsulfatase A, leading to severe white
Wei Jia et al.
Journal of chromatography. A, 1362, 110-118 (2014-08-27)
A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method. Ultrahigh-performance liquid
Anke Böhmer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 173-182 (2014-07-18)
In healthy human subjects, less than 0.2% of l-arginine is converted to l-citrulline and nitric oxide (NO) by NO synthases (NOS), a metabolic pathway present in all cell types. Assessment of NOS activity in vitro and in vivo by measuring
Richard W D Welford et al.
PloS one, 9(12), e114669-e114669 (2014-12-06)
Niemann-Pick disease type C (NP-C) is a devastating, neurovisceral lysosomal storage disorder which is characterised by variable manifestation of visceral signs, progressive neuropsychiatric deterioration and premature death, caused by mutations in the NPC1 and NPC2 genes. Due to the complexity
Jun-Feng Li et al.
PloS one, 9(4), e95095-e95095 (2014-04-17)
Accurate estimation of hepatic necroinflammation caused by chronic hepatitis C (CHC) is crucial for prediction of prognosis and design of therapeutic strategy, which is particularly true for CHC patients with normal alanine aminotransferase (ALT) level. Recent studies have shown that
Anne Warner et al.
Journal of pharmaceutical and biomedical analysis, 105, 46-54 (2014-12-22)
Stability-indicating reversed phase HPLC methods have been developed and validated for the determination of 13 potential process and degradation impurities in pemetrexed disodium drug substance (DS) and pemetrexed for injection drug product (DP). This paper describes the development of HPLC-UV
Lenka Šubčíková et al.
Journal of chromatography. A, 1378, 8-18 (2015-01-04)
Fatty acid diesters of long-chain 1,2-diols (1,2-DDE), or type II wax diesters, were analyzed in the vernix caseosa of a newborn girl. 1,2-DDE were isolated from the total lipid extract by the semipreparative TLC using plates coated with silica gel.
Jianshe Wang et al.
Journal of proteome research, 14(1), 330-341 (2014-09-03)
Perfluoroalkyl chemicals (PFASs) are a class of highly stable man-made compounds, and their toxicological impacts are currently of worldwide concern. Administration of perfluorononanoic acid (PFNA), a perfluorocarboxylic acid (PFCA) with a nine carbon backbone, resulted in dose-dependent hepatomegaly in mice
Yuanzhong Yang et al.
Analytica chimica acta, 872, 84-94 (2015-04-22)
In this study, the advantages of carrying out the analysis of peptides and tryptic digests of proteins under gradient elution conditions at pH 6.5 by reversed-phase liquid chromatography (RP-HPLC) and in-line electrospray ionisation mass spectrometry (ESI-MS) are documented. For these
Ju-Hee Ryu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 62-67 (2015-01-27)
A suitable liquid chromatography tandem mass spectrometry (LC-MS/MS) method is required to determine pelubiprofen and its active metabolite, trans-alcohol (M-D), in human plasma for pharmacokinetic studies of pelubiprofen preparations. After one-step liquid-liquid extraction (LLE) using methyl tert-butyl ether (MTBE), pelubiprofen
Rong Zhang et al.
Journal of chromatography. A, 1362, 168-179 (2014-08-28)
It has been reported that HILIC column chemistry has a great effect on the number of detected metabolites in LC-HRMS-based untargeted metabolite profiling studies. However, no systematic investigation has been carried out with regard to the optimisation of mobile phase
Anne M Filppula et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1202-1209 (2014-04-10)
Previous studies have shown that several protein kinase inhibitors are time-dependent inhibitors of cytochrome P450 (CYP) 3A. We screened 14 kinase inhibitors for time-dependent inhibition of CYP2C8 and CYP3A. Amodiaquine N-deethylation and midazolam 1'-hydroxylation were used as marker reactions for
Nadia Djabrouhou et al.
Journal of pharmaceutical and biomedical analysis, 100, 11-20 (2014-08-15)
This paper describes a new LC-MS/TOF method for the degradation products determination when Etifoxine (ETI) is submitted to different stress conditions. Chromatography is performed by using Kromasil C18 column (250mm×4.6mm, 5μm particle size). The selected mobile phase consists of formate
Mary H H Ensom et al.
The Canadian journal of hospital pharmacy, 67(4), 274-279 (2014-09-13)
Dexamethasone is widely used to treat rheumatic and endocrine disorders and chemotherapy-induced nausea and vomiting. A palatable, alcohol-free liquid formulation, with a suitable concentration to allow reasonable administration volume, is available only via extemporaneous compounding. To evaluate the stability of
Magdalena Poplawska et al.
Journal of pharmaceutical and biomedical analysis, 94, 45-53 (2014-02-18)
The new compound - flibanserin - begun to appear as a synthetic adulterant in counterfeit herbal supplements used to stimulate women sexual drive. It was detected in two samples submitted to the Polish National Medicines Institute for analysis. The second
Anna Laura Capriotti et al.
Analytical and bioanalytical chemistry, 407(6), 1705-1719 (2014-12-30)
A sensitive liquid chromatography/electrospray ionization-tandem mass spectrometry method for the determination of free and conjugated estrogens in cow milk is described. Milk samples were diluted with water and then extracted and cleaned up by solid-phase extraction using graphitized carbon black
Qinghong Su et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 119-123 (2015-02-14)
A simple, rapid and sensitive high-performance liquid chromatography tandem mass-spectrometric method (LC-MS/MS) for the novel multiple tyrosine kinase inhibitor (TKI) cabozantinib was developed and validated using erlotinib as internal standard (IS). Plasma samples were pre-treated by liquid-liquid extraction with ethyl
Zhe Wang et al.
Journal of separation science, 38(6), 925-935 (2015-02-03)
The detection, confirmation, and quantification of multiple illegal adulterants in health foods and herbal medicines by using a single analytical method are a challenge. This paper reports on a new strategy to meet this challenge by employing high-performance liquid chromatography
Venkatasubbaiah A Venkatesha et al.
Molecular cancer, 13, 259-259 (2014-12-04)
Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PIK3CA, BRAF, and others that drive tumor growth.
Jiang Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 18-25 (2015-01-24)
Millions of individuals are treated with a variety of statins that are metabolized to a variety of active metabolites. A single assay capable of simultaneously quantifying commonly used statins and their major metabolites has not been previously reported. Herein we
An efficient CoAuPd/C catalyst for hydrogen generation from formic acid at room temperature.
Zhi-Li Wang et al.
Angewandte Chemie (International ed. in English), 52(16), 4406-4409 (2013-03-21)
Jérémy Carlier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 65-76 (2014-12-02)
Plant poisonings have left their mark on history and still cause many deaths, whether intentional or accidental. The means to show toxicological evidence of such poisonings should be implemented with great care. This article presents a technique for measuring thirty-nine
Deborah Montenarh et al.
Drug testing and analysis, 7(3), 214-240 (2014-04-23)
In the present study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) multi-analyte approach using one single work-up approach in whole blood, plasma, serum, post-mortem blood, liver tissue, gastric content, hair, and urine was developed for fast target screening and reliable identification
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