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Nelly Del Socorro Cruz-Cansino et al.
Ultrasonics sonochemistry, 27, 277-286 (2015-07-19)
The objective of this study was to evaluate changes in color, betalain content, browning index, viscosity, physical stability, microbiological growth, antioxidant content and antioxidant activity of purple cactus pear juice during storage after thermoultrasonication at 80% amplitude level for 15
Zulin Zhang et al.
Journal of separation science, 37(24), 3699-3705 (2014-10-02)
A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect the recovery of pesticides, such as the type of
Dongguo Wang et al.
Journal of medical microbiology, 63(Pt 7), 981-987 (2014-04-10)
Three Klebsiella pneumoniae isolates exhibiting high-level resistance to carbapenem were analysed by PCR, PFGE, gene mapping, plasmid conjugation and Southern blot hybridization using a blaKPC probe. In addition to the frequently reported blaKPC-2 and blaKPC-3 genes, a novel blaKPC-15 gene
Grazia Giana et al.
Journal of neuroimmunology, 278, 212-222 (2014-12-04)
Interest is rising for auto-immune contribution in neuro-psychiatry. We evaluated the auto-antibodies against dopamine transporter (DAT aAbs) in 61 children (46 ADHD who met DSM-IV-TR criteria, 15 healthy controls). ADHD patients were assigned, according to severity, either to a non-pharmacological
Sonam Gupta et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 778, 22-36 (2015-03-03)
The present study was conducted to investigate the effect of the neurotoxins 6-hydroxydopamine and lipopolysaccharide on astrocytes. Rat astrocyte C6 cells were treated with different concentration of 6-hydroxydopamine (6-OHDA)/lipopolysaccharides (LPS) for 24 h. Both neurotoxins significantly decreased the viability of
Daniel H Bedinger et al.
The Journal of pharmacology and experimental therapeutics, 353(1), 35-43 (2015-01-24)
The monoclonal antibody XMetA is an allosteric partial agonist of the insulin receptor (IR), which activates the metabolic Akt kinase signaling pathway while having little or no effect on the mitogenic extracellular signal-regulated kinase (ERK) signaling pathway. To investigate the
Marcela Cataldi et al.
Virology, 485, 340-354 (2015-09-04)
Vesicular stomatitis virus (VSV) is an effective oncolytic virus against most human pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to oncolytic VSV-ΔM51 infection. To better understand the mechanism of resistance, we tested a
Laura J Marholz et al.
ACS chemical biology, 10(1), 129-137 (2014-10-22)
JmjC-domain containing histone demethylases (JHDMs) play critical roles in many key cellular processes and have been implicated in multiple disease conditions. Each enzyme within this family is known to have a strict substrate scope, specifically the position of the lysine
Chien-Wen Chen et al.
PloS one, 10(5), e0126121-e0126121 (2015-05-06)
Betanodavirus is a causative agent of viral nervous necrosis syndrome in many important aquaculture marine fish larvae, resulting in high global mortality. The coat protein of Betanodavirus is the sole structural protein, and it can assemble the virion particle by
Jared M Odegard et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(2), 41-53 (2015-02-07)
Dendritic cells (DCs) are essential antigen-presenting cells for the initiation of cytotoxic T-cell responses and therefore attractive targets for cancer immunotherapy. We have developed an integration-deficient lentiviral vector termed ID-VP02 that is designed to deliver antigen-encoding nucleic acids selectively to
Regina Tavano et al.
Biochimica et biophysica acta, 1848(1 Pt A), 134-144 (2014-10-14)
Peptaibiotics, non-ribosomally synthetized peptides from various ascomycetes, are uniquely characterized by dialkylated a-amino acids, a rigid heli cal conformation, and membrane permeation properties. Although generally considered as antimicrobial peptides, peptaibiotics may display other toxicological properties, and their function is in
Qunying Lin et al.
Cancer epidemiology, 39(4), 539-544 (2015-07-01)
Osteopontin (OPN) and vascular endothelial growth factor (VEGF) play important roles in cancer progression and angiogenesis. In the current study we aimed to investigate the clinical significance of OPN and VEGF expression in patients with non-small-cell lung cancer (NSCLC) and
Yanzuo Chen et al.
International journal of nanomedicine, 10, 4043-4057 (2015-07-08)
The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most
Airie Kim et al.
Blood cells, molecules & diseases, 56(1), 31-36 (2015-11-26)
Acute and severe anemia of inflammation (AI) is a common complication of various clinical syndromes, including fulminant infections, critical illness with multiorgan failure, and exacerbations of autoimmune diseases. Building on recent data showing beneficial results with isocitrate treatment for chronic
Mei-Shu Chen et al.
Developmental neurobiology, 75(3), 232-248 (2014-08-12)
FGF1 is involved in multiple biological functions and exhibits the importance in neuroprotective effects. Our previous studies indicated that, in human brain and retina, the FGF1B promoter controlled the expression of FGF1. However, the exact function and regulation of FGF1
Ryoji Funadani et al.
Microbes and environments, 28(1), 149-152 (2012-12-28)
The first sign of excysting Colpoda cucullus cells is the initiation of the pulsation of a contractile vacuole, which is then replaced by a non-pulsating vacuole (excystment vacuole) that continues to expand and finally ruptures the outermost cyst wall (ectocyst)
Judyta K Juranek et al.
Journal of molecular neuroscience : MN, 55(2), 297-304 (2014-05-24)
The superior cervical ganglion (SCG) is a center of sympathetic innervation of all head and neck organs. SCG sympathetic preganglionic neurons (SPN) were found in the nucleus intermediolateralis pars principalis (IMLpp), the nucleus intermediolateralis pars funicularis (IMLpf), the nucleus intercalatus
Michael Skwirba et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(10), 1020-1031 (2014-04-05)
Chronic allograft injury (CAI) limits the long-term success of renal transplantation. Nestin is a marker of progenitor cells, which probably contribute to its pathogenesis. We hypothesize that nestin is induced by ischemia/reperfusion injury and acute rejection, main risk factors for
Jens E V Petersen et al.
Thrombosis and haemostasis, 114(5), 1038-1048 (2015-07-15)
The Endothelial Protein C receptor (EPCR) is essential for the anticoagulant and cytoprotective functions of the Protein C (PC) system. Selected variants of the malaria parasite protein, Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) associated with severe malaria, including cerebral
Cathrine Kolster Fog et al.
Blood, 125(8), 1272-1281 (2014-12-17)
The PR-domain (PRDM) family of genes encodes transcriptional regulators, several of which are deregulated in cancer. By using a functional screening approach, we sought to identify novel tumor suppressors among the PRDMs. Here we demonstrate oncogenic collaboration between depletion of
Zana Lukic et al.
Journal of virology, 88(23), 13613-13625 (2014-09-19)
Following entry into the target cell, human immunodeficiency virus type 1 (HIV-1) must reverse transcribe its RNA genome to DNA and traffic to the nuclear envelope, where the viral genome is translocated into the nucleus for subsequent integration into the
Krzysztof Babiuch et al.
Biomacromolecules, 16(7), 1948-1957 (2015-06-10)
Inspired by upregulated levels of fucosylated proteins on the surfaces of multiple types of cancer cells, micelles carrying β-l-fucose and β-d-glucose were prepared. A range of block copolymers were synthesized by reacting a mixture of 2-azidoethyl β-l-fucopyranoside (FucEtN3) and 2-azideoethyl
Allan F Wiechmann et al.
PloS one, 9(11), e113810-e113810 (2014-11-21)
The corneal epithelium provides a protective barrier against pathogen entrance and abrasive forces, largely due to the intercellular junctional complexes between neighboring cells. After a prescribed duration at the corneal surface, tight junctions between squamous surface cells must be disrupted
Laurie Bruzzese et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(2), 140-147 (2015-05-23)
The nucleoside adenosine acts on the nervous and cardiovascular systems via the A2A receptor (A2AR). In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine
Achilleas G Mitrakas et al.
Anti-cancer drugs, 25(10), 1182-1191 (2014-07-19)
Abnormal mitochondrial function is common in cancer cells and activates metabolic pathways suppressed in normal tissues. Experimental and clinical studies suggest that mitochondria might serve as targets for novel anticancer therapies. We investigated whether mitochondrial metabolism-interfering agents (MMIAs) available currently
Marie Hagbom et al.
Scientific reports, 5, 11431-11431 (2015-06-24)
By the use of a modified ionizer device we describe effective prevention of airborne transmitted influenza A (strain Panama 99) virus infection between animals and inactivation of virus (>97%). Active ionizer prevented 100% (4/4) of guinea pigs from infection. Moreover
Yang Lei et al.
Journal of controlled release : official journal of the Controlled Release Society, 196, 79-86 (2014-10-07)
Elastin-specific medial arterial calcification (MAC) is an arterial disease commonly referred as Monckeberg's sclerosis. It causes significant arterial stiffness, and as yet, no clinical therapy exists to prevent or reverse it. We developed albumin nanoparticles (NPs) loaded with disodium ethylene
Nick Anim-Nyame et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), 788-791 (2015-07-15)
Endothelial dysfunction and insulin resistance (IR) are established features of pre-eclampsia, however the cause and effect relationship between them remain unexplained. Circulating endothelial cells (CEC) are increased in pre-eclampsia and appear to correlate with the degree of endothelial dysfunction. We
Devandir Antonio de Souza Junior et al.
PloS one, 10(12), e0144081-e0144081 (2015-12-04)
Mast cell proteases are thought to be involved with tumor progression and neo-vascularization. However, their exact role is still unclear. The present study was undertaken to further elucidate the function of specific subtypes of recombinant mouse mast cell proteases (rmMCP-6
Amany Abdelkader et al.
American journal of physiology. Renal physiology, 306(9), F1026-F1038 (2014-03-07)
Tissue hypoxia has been demonstrated, in both the renal cortex and medulla, during the acute phase of reperfusion after ischemia induced by occlusion of the aorta upstream from the kidney. However, there are also recent clinical observations indicating relatively well
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