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Yiran Xia et al.
Pharmaceutical development and technology, 20(3), 375-379 (2014-02-04)
The aim of this research was to develop and assess a new dissolution apparatus for orodispersible films (ODFs). The new apparatus was based on a flow-through cell design which requires only a limited amount of dissolution medium and can automatically
G Astrid Garzón et al.
Journal of agricultural and food chemistry, 63(6), 1803-1811 (2015-02-11)
The contents and profile of polyphenols were analyzed in edible petals of nasturtium flowers (Tropaeolum majus) of three colors, and their oxygen radical absorbance capacities (ORAC) were compared. Three primary anthocyanins (ACNs) and 15 non-ACN phenolic compounds including hydroxycinammic acids
G Cisbani et al.
Cell transplantation, 23(10), 1267-1278 (2013-06-19)
Cell replacement therapies have yielded variable and short-lived benefits in Huntington's disease (HD) patients. This suboptimal outcome is likely due to the fact that graft survival is compromised long term because grafts are subjected to a host's microglial inflammatory response
Elena V Parfenyuk et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1038-1045 (2014-10-02)
Biodegradable, controlled-release carrier materials with non-toxic degradation products are very valuable for delivery of cardiovascular drugs. This study is a part of development of novel form of vasodilator molsidomine to improve pharmacokinetic and consumer properties of the drug. It focuses
Róbert Kormány et al.
Journal of pharmaceutical and biomedical analysis, 94, 188-195 (2014-03-08)
In this contribution, the possibility to automatically transfer RPLC methods between different column dimensions and instruments was evaluated using commercial modelling software. The method transfer reliability was tested with loratadine and its 7 related pharmacopeial impurities. In this study, state-of-the-art
Agnieszka Kosińska-Cagnazzo et al.
Food chemistry, 170, 288-294 (2014-10-13)
Strawberry fruits are highly valued for their taste and nutritional value. However, results describing the bioaccessibility and intestinal absorption of phenolic compounds from strawberries are still scarce. In our study, a combined in vitro digestion/Caco-2 absorption model was used to
Xiaofang Jia et al.
Digestive diseases and sciences, 59(7), 1490-1501 (2014-01-23)
Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathways. We aimed to further
D N Nguyen et al.
International journal of pharmaceutics, 475(1-2), 214-226 (2014-09-03)
This study was the first investigation into the potential of a fixed dose combination of ritonavir and darunavir in the form of dispersible powders prepared by spray drying. A common polymer (hydroxypropyl methylcellulose, polyvinylpyrrolidone, and polyvinylpyrrolidone-vinyl acetate 64) was formulated
Brendan J Holland et al.
Analytica chimica acta, 842, 35-41 (2014-08-17)
Sodium polyphosphate is commonly used to enhance chemiluminescence reactions with acidic potassium permanganate through a dual enhancement mechanism, but commercially available polyphosphates vary greatly in composition. We have examined the influence of polyphosphate composition and concentration on both the dual
Shuai Qian et al.
International journal of pharmaceutics, 477(1-2), 442-453 (2014-12-03)
Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's disease (AD), has been extensively investigated in last seven decades. After dimerization of THA via a 7-carbon alkyl spacer, bis(7)-tacrine (B7T) showed much potent anti-AChE activity
Veniero Gambaro et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 957, 68-76 (2014-03-25)
In vitro incubation with human liver microsomes of JWH-018, JWH-073, JWH-122 and for the first time 1-butyl-3-(1-(4-methyl)naphthoyl)indole (the 4-methylnaphthoyl analogue of JWH-073) was investigated to identify the principal metabolites of alkylindole synthetic cannabinoids, thus helping the discovering of synthetic cannabinoids
A simple microplate-based method for the determination of alpha-amylase activity using the glucose assay kit (GOD method)
Visvanathan R, et al.
Food Chemistry, 211, 853-859 (2016)
Xu Wang et al.
The Analyst, 140(5), 1453-1458 (2015-01-21)
A simple, sensitive and cost-effective method for the analysis of the mycotoxin aflatoxin B1 (AFB1) has been established based on controlled growth of immunogold. AFB1-BSA conjugate modified magnetic beads were employed as capture probe and anti-AFB1 antibody-coated gold colloids were
R Kanďár et al.
Andrologia, 46(10), 1079-1088 (2013-10-16)
A method is described here for the determination of total glutathione (TGSH) and glutathione disulphide (GSSG) in the seminal plasma of the male partners of couples requesting a fertility evaluation. A suitable sample preparation procedure prior to high-performance liquid chromatography
Jake Chng et al.
mAbs, 7(2), 403-412 (2015-01-27)
Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the
Kishore Cholkar et al.
AAPS PharmSciTech, 15(6), 1454-1467 (2014-07-02)
The purpose of this study was to develop a clear aqueous mixed nanomicellar formulation (MNF) of dexamethasone utilizing both D-α-tocopherol polyethylene glycol-1000 succinate (Vit E TPGS) and octoxynol-40 (Oc-40). In this study, Vit E TPGS and Oc-40 are independent variables.
Raquel dos Santos et al.
Journal of chromatography. A, 1355, 115-124 (2014-06-21)
In this work, phenylboronic acid (PBA) was thoroughly investigated as a synthetic ligand for the purification of an immunoglobulin G (IgG) from a clarified cell supernatant from Chinese Hamster Ovary (CHO) cell cultures. In particular, the study was focused on
Wenying Fan et al.
Analytical and bioanalytical chemistry, 406(28), 7261-7273 (2014-09-23)
In this work, a novel ionic liquid (IL) chemically bonded sol-gel coating was prepared for stir bar sorptive extraction (SBSE) of nonsteroidal anti-inflammatory drugs (NSAIDs) followed by high-performance liquid chromatography-ultraviolet detection (HPLC-UV). By using γ-(methacryloxypropyl)trimethoxysilane (KH-570) as a bridging agent
Cameron P Brewer et al.
International journal of sport nutrition and exercise metabolism, 23(2), 187-194 (2012-11-02)
Research into supplementation with sodium phosphate has not investigated the effects of a repeated supplementation phase. Therefore, this study examined the potential additive effects of repeated sodium phosphate (SP) supplementation on cycling time-trial performance and peak oxygen uptake (VO2peak). Trained
Pei-Yu Liu et al.
Electrophoresis, 33(19-20), 3079-3086 (2012-09-22)
A CD-modified CE method was established for quantitative determination of seven hydroxy acids in cosmetic products. This method involved chemometric experimental design aspects, including fractional factorial design and central composite design. Chemometric experimental design was used to enhance the method's
Tyler W Stradleigh et al.
The Journal of comparative neurology, 523(4), 545-564 (2014-10-07)
Protocols for characterizing cellular phenotypes commonly use chemical fixatives to preserve anatomical features, mechanically stabilize tissue, and stop physiological responses. Formaldehyde, diluted in either phosphate-buffered saline or phosphate buffer, has been widely used in studies of neurons, especially in conjunction
Lucas Maciel Mauriz Marques et al.
Journal of pharmaceutical and biomedical analysis, 95, 113-120 (2014-03-29)
Because piplartine (PPT) has demonstrated biological activities, such as cytotoxic, anxiolytic, antidepressant, antifungal and antiplatelet activities, this molecule is a relevant drug candidate. The metabolic fate of drug candidates is an essential requirement in assessing their safety and efficacy. Based
C Tony Liu et al.
Journal of the American Chemical Society, 136(29), 10349-10360 (2014-07-01)
Electrostatic interactions play an important role in enzyme catalysis by guiding ligand binding and facilitating chemical reactions. These electrostatic interactions are modulated by conformational changes occurring over the catalytic cycle. Herein, the changes in active site electrostatic microenvironments are examined
Filis Kazazi-Hyseni et al.
Pharmaceutical research, 31(10), 2844-2856 (2014-05-16)
The aim of this study was the development of poly(D,L-lactide-co-glycolide) (PLGA) microspheres with controlled porosity, to obtain microspheres that afford continuous release of a macromolecular model compound (blue dextran). PLGA microspheres with a size of around 40 μm and narrow size
Ana Oliveira et al.
Life sciences, 109(2), 104-110 (2014-06-27)
Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-administration of drugs that interfere with metabolism may affect analgesia. The aim of the study was to investigate the
Samuel Adler et al.
Gastrointestinal endoscopy, 76(6), 1170-1174 (2012-10-03)
Colon capsule endoscopy (CCE) is a noninvasive technique for the detection of colorectal lesions. However, for CCE to be offered as an out-of-clinic procedure, the system needs to automatically alert the patient when to ingest the laxative (booster). We tested
Barrett Rabinow et al.
Inflammation, 38(1), 40-60 (2014-09-06)
Current therapeutic treatment options for osteoarthritis entail significant safety concerns. A novel ropivacaine crystalline microsuspension for bolus intra-articular (IA) delivery was thus developed and studied in a peptidoglycan polysaccharide (PGPS)-induced ankle swelling rat model. Compared with celecoxib controls, both oral
Fatal electrolyte abnormalities following enema administration.
Dominika Szoke et al.
Clinical chemistry, 58(11), 1515-1518 (2012-10-30)
Mollah Md Hamiduzzaman et al.
Journal of invertebrate pathology, 126, 12-20 (2014-12-21)
For the first time, adults and brood of Africanized and European honey bees (Apis mellifera) were compared for relative virus levels over 48 h following Varroa destructor parasitism or injection of V. destructor homogenate. Rates of increase of deformed wing
Tarek A Ahmed et al.
AAPS PharmSciTech, 15(3), 772-780 (2014-03-22)
The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ microparticles (ISM). N-Methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), triacetin
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