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Nathaly Reyes-Garcés et al.
Journal of chromatography. A, 1374, 40-49 (2014-12-03)
Simple, fast and efficient sample preparation approaches that allow high-throughput isolation of various compounds from complex matrices are highly desired in bioanalysis. Particularly sought are methods that can, without sacrificing time, easily remove matrix interferences capable of inducing ionization suppression/enhancement
Arno Bergmann et al.
Nature communications, 6, 8625-8625 (2015-10-13)
Water splitting catalysed by earth-abundant materials is pivotal for global-scale production of non-fossil fuels, yet our understanding of the active catalyst structure and reactivity is still insufficient. Here we report on the structurally reversible evolution of crystalline Co3O4 electrocatalysts during
Alex R Hill et al.
European journal of mass spectrometry (Chichester, England), 21(3), 265-274 (2015-08-27)
The complexation of triacetone triperoxide (TATP) with a range of alkali metals has been studied by electrospray ionisation-mass spectrometry yield [M+Cat](+) ions for all of the alkali metals. The formation of [2TATP+Li+LiX](+) (X = Br, Cl) sandwich complexes was also
Jhansi Rani Vangavaragu et al.
Journal of Alzheimer's disease : JAD, 42(1), 333-344 (2014-05-27)
A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β
Anna Flis et al.
Pharmacological reports : PR, 67(1), 1-8 (2015-01-07)
Human prostate cancer (hPCa) is the most commonly diagnosed cancer in elderly men and is the second leading cause of male cancer death. Data from epidemiological, eco-environmental, nutritional prevention and clinical trials suggest that selenium Se(IV) can prevent prostate cancer.
Ranjita Misra et al.
International journal of pharmaceutics, 475(1-2), 372-384 (2014-09-03)
Over expression of drug efflux transporters such as P-glycoprotein (P-gp) cumulatively leading to multidrug resistance (MDR) embodies a major hindrance for successful cancer therapy. A paradigm nanomedicinal approach involving an anticancer drug and modulators of drug resistance within one multifunctional
Maria Lapteva et al.
Nanoscale, 7(44), 18651-18662 (2015-10-27)
Acne vulgaris is a highly prevalent dermatological disease of the pilosebaceous unit (PSU). An inability to target drug delivery to the PSU results in poor treatment efficacy and the incidence of local side-effects. Cutaneous application of nanoparticulate systems is reported
Qingquan Guo et al.
Analytica chimica acta, 852, 244-249 (2014-12-03)
A label-free and enzyme-free sensitive fluorescent detection of human immunodeficiency virus (HIV) deoxyribonucleic acid (DNA) based on isothermal hybridization chain reaction (HCR) was developed. A G-quadruplex sequence which was incorporated into one of the two hairpin probes was inactive in
Larry N Agbor et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 688-698 (2014-10-16)
The mechanisms that mediate the cardiovascular protective effects of omega 3 (n-3) polyunsaturated fatty acids (PUFAs) have not been fully elucidated. Cytochrome P450 1A1 efficiently metabolizes n-3 PUFAs to potent vasodilators. Thus, we hypothesized that dietary n-3 PUFAs increase nitric
Nahid Amini et al.
Journal of pharmaceutical and biomedical analysis, 98, 140-143 (2014-06-13)
Positron emission tomography (PET) is an imaging technique based on the use of radioligands labeled with short lived radionuclides, such as (11)C (t½=20.4min) and (18)F (t½=109.8min), which as a consequence often requires rapid plasma protein binding analysis methods. In addition
Karina Lopes Dornelas et al.
Analytica chimica acta, 858, 82-90 (2015-01-20)
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and
Marina Makrecka et al.
Molecular and cellular biochemistry, 395(1-2), 1-10 (2014-06-01)
In the heart, a nutritional state (fed or fasted) is characterized by a unique energy metabolism pattern determined by the availability of substrates. Increased availability of acylcarnitines has been associated with decreased glucose utilization; however, the effects of long-chain acylcarnitines
Saqlain Haider et al.
European journal of medicinal chemistry, 81, 204-217 (2014-05-20)
A library of novel bis-heterocycles containing 2-mercaptobenzoxazole based 1,2,3-triazoles has been synthesized using click chemistry approach. The compound 4 exhibited the most potent in vivo anti-inflammatory activity with 66.66% and 61.11% inhibition in comparison to celecoxib which showed 72.22% and 65.55%
Vašková Janka et al.
In vitro cellular & developmental biology. Animal, 51(9), 964-974 (2015-05-29)
Although knowledge of cancer management is extensive, mortality is not currently declining in this area. It is therefore important to implement a long-term strategy that would aim to prevent these serious diseases. Ferrocene-related organometallic compounds are promising candidates for design
Wong Pooi See et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(10), 997-1003 (2015-10-16)
A new approach for the development of a highly sensitive aluminium(III) ion sensor via the preconcentration of aluminium(III) ion with a self-assembled monolayer on a gold nanoparticles modified screen-printed carbon electrode and current mediation by potassium ferricyanide redox behavior during
Hye Yeong Lee et al.
Tissue engineering. Part A, 21(13-14), 2044-2052 (2015-04-11)
Stem cells are a promising source of tissue engineering due to their differentiation potential. Today, direct transplantation of stem cells for cell therapy is commonly performed. However, in cases of nerve injury, direct transplantation of cells could lead to secondary
P Ranawat et al.
Andrologia, 46(6), 650-658 (2013-07-16)
Resveratrol has been considered as an antioxidant in biological system. However, its role in male reproductive biology has not yet been evaluated in much detail. Present study analysed its effect on male reproductive function in adult mouse, after its intraperitoneal
Yuchen Pan et al.
Analytical chemistry, 86(20), 10357-10364 (2014-09-19)
We describe a platform for high-throughput electrophoretic mobility shift assays (EMSAs) for identification and characterization of molecular binding reactions. A photopatterned free-standing polyacrylamide gel array comprised of 8 mm-scale polyacrylamide gel strips acts as a chassis for 96 concurrent EMSAs.
Nungruthai Suphrom et al.
The Journal of pharmacy and pharmacology, 66(9), 1282-1293 (2014-06-07)
Curcuma aeruginosa Roxb. extract is a 5α-reductase antagonist that can be used to treat hair loss. We aimed to study the stability of antiandrogenic constituents, germacrone and other sesquiterpene components in the extract. Germacrone and the extract were analyzed as solid
Mehmet Kanter et al.
The Journal of surgical research, 193(2), 909-919 (2014-09-28)
The study aimed to examine whether methylene blue (MB) prevents different pulmonary aspiration materials-induced lung injury in rats. The experiments were designed in 60 Sprague-Dawley rats, ranging in weight from 250-300 g, randomly allotted into one of six groups (n
Janina Seubert et al.
Human brain mapping, 36(5), 1662-1676 (2014-12-30)
Food perception is characterized by a transition from initially separate sensations of the olfactory and gustatory properties of the object toward their combined sensory experience during consumption. The holistic flavor experience, which occurs as the smell and taste merge, extends
Contrasting actions of group I metabotropic glutamate receptors in distinct mouse striatal neurones.
John G Partridge et al.
The Journal of physiology, 592(13), 2721-2733 (2014-04-09)
In mouse striatum, metabotropic glutamate receptor (mGluR) activation leads to several modulatory effects in synaptic transmission. These effects range from dampening of glutamate release from excitatory terminals to depolarization of divergent classes of interneurones. We compared the action of group
Sandeep Deshmukh et al.
Journal of chromatography. A, 1388, 1-8 (2015-03-01)
Accurate quantitation of compounds in samples of biological origin is often hampered by matrix interferences one of which occurs in GC-MS analysis from the presence of highly abundant phosphate. Consequently, high concentrations of phosphate need to be removed before sample
Damião Pergentino de Sousa et al.
Natural product communications, 10(11), 1893-1896 (2016-01-12)
Aromatic plants produce volatile substances with high therapeutic potential. In view of the need for new respiratory and cardiovascular system pharmacological agents, the present study reports on the spasmolytic activity of two enantiomers of carvone and limonene, constituents of essential
Yarden Katz et al.
eLife, 3, e03915-e03915 (2014-11-08)
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated but frequently
Luxi Z Swisher et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(7), 1695-1704 (2015-05-12)
The proteolytic activity of cathepsin B in complex breast cell lysates has been measured with alternating current voltammetry (ACV) using ferrocene (Fc)-labeled-tetrapeptides immobilized on nanoelectrode arrays (NEAs) fabricated with vertically aligned carbon nanofibers (VACNFs). Four types of breast cells have
Priscila de Souza et al.
Canadian journal of physiology and pharmacology, 92(10), 887-891 (2014-10-02)
Smoothelin-B (SMTL-B) and calponin-1 are important regulators of vascular contraction. SMTL-B contains a calponin-homology domain and is structurally similar to cardiac troponin T. As calponin-1 and troponin T are proteolyzed by intracellular matrix metalloproteinase (MMP)-2 in oxidative stress injury, we
S Guerrero et al.
The Analyst, 140(22), 7527-7533 (2015-08-11)
The first electrochemical immunosensor for the determination of peptide YY is reported in this paper. A novel electrochemical platform, prepared by the electrochemical grafting of the diazonium salt of 4-aminobenzoic acid onto a reduced graphene oxide-modified glassy carbon electrode, was
Leah C Jimmerson et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 163-172 (2015-01-03)
Ribavirin (RBV) is a nucleoside analog used to treat a variety of DNA and RNA viruses. RBV undergoes intracellular phosphorylation to a mono- (MP), di- (DP), and triphosphate (TP). The phosphorylated forms have been associated with the mechanisms of antiviral
Romchat Chutoprapat et al.
The Journal of pharmacy and pharmacology, 66(7), 943-953 (2014-04-05)
To investigate the influence of the hydrophilic polymer, polyvinylpyrrolidone (PVP) on the ex-vivo permeability of the poorly water-soluble photosensitizer, chlorin e6 (Ce6) using the chick chorioallantoic membrane (CAM) model. The CAM was removed from the fertilized chicken egg at embryo
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