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Rafiou Agoro et al.
PloS one, 13(5), e0196921-e0196921 (2018-05-18)
Macrophages play crucial roles in innate immune response and in the priming of adaptive immunity, and are characterized by their phenotypic heterogeneity and plasticity. Reprogramming intracellular metabolism in response to microenvironmental signals is required for M1/M2 macrophage polarization and function.
Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
A D Nelson et al.
Molecular psychiatry, 25(11), 2800-2817 (2018-12-07)
GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key
Raúl Ferrer-Gallego et al.
Langmuir : the ACS journal of surfaces and colloids, 31(30), 8392-8401 (2015-07-15)
The interaction between phenolic compounds and salivary proteins is considered the basis of the poorly understood phenomenon of astringency. Furthermore, this interaction is an important factor in relation to their bioavailability. In this work, interactions between anthocyanin and human salivary
Chiara Macchi et al.
Molecular and cellular endocrinology, 454, 135-145 (2017-06-27)
Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothalamic derangements.
Jiping Li et al.
Ecotoxicology and environmental safety, 191, 110156-110156 (2020-01-21)
Roxithromycin (ROX) has received increasing concern due to its large usage, ubiquitous detection in environment and high ecotoxicology risk. This study investigated the acute and chronic effects of ROX on the growth, chlorophyll, antioxidant enzymes, and malonaldehyde (MDA) content of
Jane Snelling et al.
Journal of food protection, 83(5), 836-843 (2020-01-14)
Recent outbreaks traced to contaminated flour have created a need in the milling industry for a process that reduces pathogens in wheat while maintaining its functional properties. Vacuum steam treatment is a promising technology for treatment of low-moisture foods. Traditional
Gheyath K Nasrallah et al.
Neurotoxicology and teratology, 72, 29-38 (2019-02-03)
Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity to iron and reduce toxicity. Although its efficacy was established in one small
Satoshi Kimura et al.
Nature chemical biology, 16(9), 964-972 (2020-06-10)
Chemical modifications of the nucleosides that comprise transfer RNAs are diverse. However, the structure, location and extent of modifications have been systematically charted in very few organisms. Here, we describe an approach in which rapid prediction of modified sites through
Donya Novin et al.
Bioprocess and biosystems engineering, 44(1), 39-45 (2020-08-01)
Probiotics, in particular, lactic acid bacteria (LAB) are widely used as starter cultures in food and pharmaceutical industries. Presence of LAB supports the production and preservation of a diverse range of food products, provides a positive effect on the human
E Argyridou et al.
Heredity, 119(1), 27-34 (2017-03-16)
As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter
Jessica Bordini et al.
Cancers, 12(4) (2020-04-17)
Adaptation to import iron for proliferation makes cancer cells potentially sensitive to iron toxicity. Iron loading impairs multiple myeloma (MM) cell proliferation and increases the efficacy of the proteasome inhibitor bortezomib. Here, we defined the mechanisms of iron toxicity in
Emily L Yarosz et al.
Journal of immunology (Baltimore, Md. : 1950), 204(7), 1708-1713 (2020-03-04)
Iron has long been established as a critical mediator of T cell development and proliferation. However, the mechanisms by which iron controls CD4 T cell activation and expansion remain poorly understood. In this study, we show that stimulation of CD4
Giuseppina Camiolo et al.
International journal of molecular sciences, 20(3) (2019-02-03)
Iron toxicity is associated with organ injury and has been reported in various clinical conditions, such as hemochromatosis, thalassemia major, and myelodysplastic syndromes. Therefore, iron chelation therapy represents a pivotal therapy for these patients during their lifetime. The aim of
Dong Gil Lee et al.
Cell death & disease, 11(3), 204-204 (2020-03-25)
Iron is an essential element for cellular functions, including those of neuronal cells. However, an imbalance of iron homeostasis, such as iron overload, has been observed in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Iron overload causes neuronal
Zahra Sharifalhoseini et al.
Ultrasonics sonochemistry, 27, 466-473 (2015-07-19)
In the present study, the sono-synthesis of ZnO nanoparticles (NPs) was performed by simple, low-cost, and the environmentally friendly method. The synthesis of zinc oxide as an antibacterial agent was performed by an ultrasonic bath (low intensity) for the indirect
Virginia L Bass et al.
Lipids in health and disease, 19(1), 128-128 (2020-06-09)
Inhalation of common air pollutants such as diesel and biodiesel combustion products can induce vascular changes in humans which may contribute to increased mortality and morbidity associated with fine particulate matter exposures. Diesel, biodiesel, and other combustion byproducts contain fatty
Santiago Grijalvo et al.
International journal of molecular sciences, 22(1) (2020-12-31)
Two G-quadruplex forming oligonucleotides [d(TG4T)4 and d(TG6T)4] were selected as two tetramolecular quadruplex nanostructures because of their demonstrated ability to be modified with hydrophobic molecules. This allowed us to synthesize two series of G-quadruplex conjugates that differed in the number
Gerdt Müller et al.
Biotechnology and bioengineering, 114(3), 552-559 (2016-09-07)
Enzymatic catalysis plays a key role in the conversion of lignocellulosic biomass to fuels and chemicals such as lactic acid. In the last decade, the efficiency of commercial cellulase cocktails has increased significantly, in part due to the inclusion of
Shida Zhou et al.
PloS one, 12(7), e0180464-e0180464 (2017-07-04)
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN) and subsequent DA depletion in the striatum. Microglia activation and nigral iron accumulation play important roles in the pathogenesis
Yuki Doi
Applied and environmental microbiology, 81(6), 2082-2089 (2015-01-13)
Biodiesel waste is a by-product of the biodiesel production process that contains a large amount of crude glycerol. To reuse the crude glycerol, a novel bioconversion process using Enterococcus faecalis was developed through physiological studies. The E. faecalis strain W11
Lisa J Routhe et al.
Glia, 68(9), 1810-1823 (2020-02-23)
Neurodegeneration is associated with inflammation and mismanaged iron homeostasis, leading to increased concentration of non-transferrin-bound iron (NTBI) in the brain. NTBI can be taken up by cells expressing Zrt-, Irt-like protein-14 (ZIP14), which is regulated by iron overload and pro-inflammatory
Mio Kawai et al.
Journal of bioscience and bioengineering, 129(1), 47-51 (2019-08-03)
Lactic acid bacteria (LAB) grow by producing lactate from sugar. However, the accumulation of lactate inhibits their growth. Here, the lactate productivity per cell in a semi-solid medium prepared with a chlorella powder in several LAB strains was much lower
Ruomi Guo et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 20(3), 417-427 (2017-10-04)
The purpose of this study was to investigate the feasibility of dual magnetic resonance imaging (MRI) reporter genes, including ferritin heavy subunit (Fth) and transferrin receptor (TfR), which provide sufficient MRI contrast for in vivo MRI tracking, and the Deltex-1
Antonio Perfecto et al.
The Journal of nutrition, 148(8), 1229-1235 (2018-06-26)
Iron deficiency is an enduring global health problem that requires new remedial approaches. Iron absorption from soybean-derived ferritin, an ∼550-kDa iron storage protein, is comparable to bioavailable ferrous sulfate (FeSO4). However, the absorption of ferritin is reported to involve an
Mohamed Ali Abdel-Rahman et al.
Biotechnology and bioengineering, 117(6), 1673-1683 (2020-02-23)
In this study, a non-sterile (open) continuous fermentation (OCF) process with no-carbon loss was developed to improve lactic acid (LA) productivity and operational stability from the co-utilization of lignocellulose-derived sugars by thermophilic Enterococcus faecium QU 50. The effects of different
Dexin Wang et al.
Applied microbiology and biotechnology, 104(16), 7005-7021 (2020-07-10)
Bacillus subtilis naturally produces large amounts of 2,3-butanediol (2,3-BD) as a main by-product during poly-γ-glutamic acid (γ-PGA) production. 2,3-BD is a promising platform chemical in various industries, and co-production of the two chemicals has great economic benefits. Co-production of γ-PGA
Heejun Park et al.
International journal of pharmaceutics, 581, 119232-119232 (2020-04-03)
The glimepiride/L-arginine (GA) binary systems were prepared at various molar ratios by using a supercritical antisolvent (SAS) process. For comparison, the GA system was also prepared by physical mixing (PM), melt quenching (MQ), and solvent evaporation (SE) methods. Analyses by
Biswarup Jash et al.
Journal of inorganic biochemistry, 186, 301-306 (2018-07-14)
A stable zinc(II)-mediated base pair was formed within a parallel-stranded DNA duplex comprising a GNA (glycol nucleic acid) functionalized nucleoside analog containing the artificial nucleobase 1H-imidazo[4,5-f][1,10]phenanthroline (P). The formation of the metal-mediated base pair was confirmed by UV and CD
Shuo Liu et al.
Ultrasonics sonochemistry, 52, 493-504 (2018-12-31)
The carbon fibers were ultrasonically treated under nickel chloride solution, and nickel ions were attached to the surface of the carbon fibers, which replaces the nitric acid oxidation method used in the original electroless nickel plating. Electroless nickel plating was
Jean-Marc Escudier et al.
Organic & biomolecular chemistry, 17(26), 6386-6397 (2019-06-19)
We introduce the concept of Convertible and Constrained Nucleic Acids (C2NAs). By means of the synthesis of a stereocontrolled N-propargyl dioxo-1,3,2-oxaza-phosphorinane as an internucleotidic linkage, the torsional angles α and β can adopt either the canonical (g-, t) set of
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