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Gábor Csányi et al.
Pharmacological reports : PR, 60(3), 345-352 (2008-07-16)
We investigated the influence of recurrent epileptic seizures on the arachidonic acid (AA) cascade in platelets and brain microvessels, using [(14)C]AA as a tracer substrate and chromatographic determination. The recurrent epileptic seizures of male Wistar rats were induced every second
J Pearce et al.
Journal of neurocytology, 15(2), 241-252 (1986-04-01)
The fine structure of identified neuromuscular synapses of the single excitatory axon to the distal accessory flexor muscle in lobster limbs was examined with freeze-fracture and serial thin-section electron microscopy. The latter technique reveals presynaptic dense bars with synaptic vesicles
Pavan Walvekar et al.
Chemistry and physics of lipids, 214, 1-10 (2018-05-08)
Most of the bacteria are on the verge of becoming resistant to available potential antibiotics. Novel approaches to combat these drug resistant bacteria are turning out to be crucial. This study aimed to synthesize novel fatty acid based cationic amphiphiles
L Quan et al.
Stroke, 31(10), 2460-2465 (2000-10-07)
We postulated that some abnormalities in cerebrovascular function after subarachnoid hemorrhage (SAH) may involve underlying alterations in K(+) channel function. Thus, using pharmacological inhibitors, we assessed the influence of SAH on function of 2 types of K(+) channel in regulation
Pierre Garcia et al.
Organic letters, 13(8), 2030-2033 (2011-03-19)
Bimolecular cobalt-catalyzed [2 + 2 + 2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts
Jaslin Ikhsan et al.
Journal of colloid and interface science, 284(2), 383-392 (2005-03-23)
The sorption of 2-, 3-, and 4-aminopyridine on K-saturated Wyoming (SWy-K) and Texas (STx-K) and Ca-enriched Texas (STx-Ca) montmorillonite was measured at 25 degrees C with 10 mM KNO(3) or 3.3 mM Ca(NO(3))(2) as the background electrolyte. The aminopyridines adsorbed
M B Szente et al.
Brain research, 495(2), 261-270 (1989-08-28)
The mechanisms of generation of self-sustained depolarizing plateau potentials (DPs) were studied in intracellular recordings in aminopyridine-induced ictal seizure foci in the motor cortex of the cat. In some experiments single-electrode voltage clamp techniques were used and intracellular pressure injection
Jingjing Zhang et al.
Polymers, 11(6) (2019-06-05)
In order to improve the bioactivity of chitosan, we synthesized a novel series of chitosan derivatives: firstly, chitosan was reacted with methylclhlorofonmate obtaining N-methoxyformylated chitosan (1), which was then converted into N-pyridylurea chitosan derivatives (2a-2c) by amine-ester exchange reaction. In
G E Kirsch et al.
Biophysical journal, 50(4), 637-644 (1986-10-01)
Aminopyridines are known to block potassium (K) currents in excitable membranes in a manner dependent upon membrane potential, such that the block is relieved by depolarization and restored upon repolarization. In the present study, the effects of aminopyridines on voltage-dependent
Adel Mostafa et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1), 180-187 (2009-07-04)
The interactions of the electron donors 2-aminopyridine (2APY) and 3-aminopyridine (3APY) with the pi-acceptors tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), 2-chloro-1,3,5-trinitrobenzene (picryl chloride, PC), and 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil) were studied spectrophotometrically in chloroform at room temperature. The electronic and infrared spectra of the
Yusuke Masuo et al.
Pharmaceutical research, 35(11), 224-224 (2018-10-04)
Solute carrier SLC22A4 encodes the carnitine/organic cation transporter OCTN1 and is associated with inflammatory bowel disease, although little is known about how this gene is linked to pathogenesis. The aim of the present study was to identify endogenous substrates that
Xiang Gao Meng et al.
Acta crystallographica. Section C, Crystal structure communications, 63(Pt 11), o667-o670 (2007-11-09)
5-Sulfosalicylic acid (5-SSA) and 3-aminopyridine (3-APy) crystallize in the same solvent system, resulting in two kinds of 1:1 proton-transfer organic adduct, namely 3-aminopyridinium 3-carboxy-4-hydroxybenzenesulfonate monohydrate, C(5)H(7)N(2)(+).C(7)H(5)O(6)S(-).H(2)O or 3-APy.5-SSA.H(2)O, (I), and the anhydrous adduct, C(5)H(7)N(2)(+).C(7)H(5)O(6)S(-) or 3-APy.5-SSA, (II). Both compounds have
E O'Hearn et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(22), 8828-8841 (1997-11-14)
Ibogaine, an indole alkaloid that causes hallucinations, tremor, and ataxia, produces cerebellar neurotoxicity in rats, manifested by degeneration of Purkinje cells aligned in narrow parasagittal bands that are coextensive with activated glial cells. Harmaline, a closely related alkaloid that excites
Daniel Cappel et al.
Journal of chemical information and modeling, 51(10), 2581-2594 (2011-09-16)
The model binding site of the cytochrome c peroxidase (CCP) W191G mutant is used to investigate the structural and dynamic properties of the water network at the buried cavity using computational methods supported by crystallographic analysis. In particular, the differences
Nitric oxide synthase inhibitor facilitates aminopyridine induced neocortical seizure.
B Boda et al.
Neurobiology (Budapest, Hungary), 4(1-2), 103-104 (1996-01-01)
Bashar Al-Sabti et al.
Biomedical chromatography : BMC, 34(11), e4930-e4930 (2020-06-25)
This study aimed to develop an analytical method to determine the quantity of the impurity 3-aminopyridine (3AP). 3-Aminopyridine is a reactive reagent in the synthesis of linagliptin. The method was sensitive at level of 30.0 ppm of 3AP relative to linagliptin.
C D Woody et al.
Brain research, 480(1-2), 72-81 (1989-02-20)
Studies were performed in cortical neurons to determine if voltage- and time-dependent membrane currents could be recognized and characterized in the dynamic, in vivo state. Intracellular measurements made in neurons of the precruciate cortex of awake cats with single-electrode voltage-clamp
Fung Fuh Wong et al.
The Journal of organic chemistry, 77(19), 8492-8500 (2012-09-07)
A new sequential three-component heterocyclization was developed by reacting aromatic and heterocyclic substrates, including aminobenzenes, 1-aminonaphthalene, 2-aminopyrazines, 5-aminopyrazoles, 3-aminopyridine, 5-aminopyrimidine, 5-aminoquinoline, and 8-aminoquinoline, with formamide in the presence of PBr(3). The reaction gave the corresponding pyrazolo[3,4-d]pyrimidines in good yields (59-96%)
W S Lai et al.
Neuroscience letters, 67(1), 87-91 (1986-06-06)
The effect of 4-aminopyridine and its analogs on the specific binding of [3H]phencyclidine was investigated in rat brain homogenates. 4-Aminopyridine (4-AP) and 3,4-diaminopyridine displaced [3H]phencyclidine binding, while 3-aminopyridine was without effect. The concentrations of 4-AP required for inhibition of binding
Chao Fang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(4), 1588-1593 (2008-07-22)
Our algorithm [B. Tian, G. Wu, G. Liu, J. Chem. Phys. 87 (1987) 7300] is introduced to obtain the temporal bond polarizabilities of 2- and 3-aminopyridine from their Raman intensities, which supply fruitful electronic information of the nonresonant Raman excited
J Karpagam et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 76(5), 502-512 (2010-05-21)
In this work, we will report a combined experimental and theoretical study on molecular structure and vibrational analysis of 3,4-diaminopyridine (3,4-DAP) and 3-aminopyridine (3-AP). The Fourier transform infrared and Fourier transform Raman spectra of 3,4-DAP were recorded in the solid
Marlen Dierich et al.
Frontiers in molecular neuroscience, 11, 11-11 (2018-02-15)
The three members of the
Kazuhiro Yoshida et al.
Organic letters, 11(3), 515-518 (2009-01-02)
New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/deprotection of nitrogen-containing dienes 4 are the key processes of the routes. An application of RCM/oxidation/deprotection to the synthesis of 3-aminopyridine 13f is also described.
B Boda et al.
Brain research, 574(1-2), 237-243 (1992-03-06)
The effects of unilateral electrical stimulation of the substantia nigra pars reticulata (SNpr) on the electrocorticographic (ECoG) manifestations of seizures were studied in anesthetized rats. Epileptiform activity was provoked in the primary focus (Pf) by unilateral, local application of 3-aminopyridine
Pradhumna Mahat Chhetri et al.
Polymers, 11(3) (2019-04-10)
Four one-dimensional (1D) mercury(II) halide coordination polymers have been synthesized by using a semi-rigid N-donor ligand, 2,2'-(1,4-phenylene)-bis(N-(pyridin-3-yl)acetamide) (1,4-pbpa). While [Hg(1,4-pbpa)Cl₂·CH₃OH]n, 1, forms a sinusoidal chain, the complexes [Hg(1,4-pbpa)X₂]n (X = Cl, 2; Br, 3; I, 4) are helical. The sinusoidal
Koushik Sarkar et al.
Chemistry, an Asian journal, 14(1), 194-204 (2018-10-26)
A structural rationale was adopted to design a series of metallogels from a newly synthesized urea-functionalized dicarboxylate ligand, namely, 5-[3-(pyridin-3-yl)ureido]isophthalic acid (PUIA), that produces metallogels upon reaction with various metal salts (CuII , ZnII , CoII , CdII , and
Elizabeta Sauer et al.
Antimicrobial agents and chemotherapy, 48(12), 4532-4541 (2004-11-25)
The utilization pathway for the uptake of NAD and nicotinamide riboside was previously characterized for Haemophilus influenzae. We now report on the cellular location, topology, and substrate specificity of PnuC. pnuC of H. influenzae is only distantly related to pnuC
B Barna et al.
Acta biologica Hungarica, 50(1-3), 257-267 (1999-11-26)
The effect of GYKI 52466, a selective, non-competitive antagonist of the AMPA glutamate receptor subtype was investigated on the development, expression and propagation of 3-aminopyridine-induced cortical ictal activity, both in the primary and secondary focus. In one group of animals
A Slézia et al.
Neurobiology of disease, 16(3), 490-499 (2004-07-21)
Uridine, like adenosine, is released under sustained depolarization and it can inhibit hippocampal neuronal activity, suggesting that uridine may be released during seizures and can be involved in epileptic mechanisms. In an in vivo microdialysis study, we measured the extracellular
M Szente et al.
Brain research, 413(2), 368-373 (1987-06-16)
Intracellular recordings were obtained from neurons in the motor cortex of anesthetized cats in order to examine membrane and synaptic processes involved in aminopyridine (AP)-induced ictal seizure activity. Depolarizing and hyperpolarizing membrane potential sequences which behaved as large, synchronized excitatory
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