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Sergej M Ostojic et al.
The British journal of nutrition, 110(5), 865-870 (2013-01-29)
Guanidinoacetic acid (GAA) is the natural biosynthetic precursor of creatine, in a metabolic reaction that requires only a methyl group transfer. The use of GAA as a food additive for restoring creatine load in human tissues is rather unexplored and
John T Connelly et al.
Analytical chemistry, 87(15), 7595-7601 (2015-06-25)
Clinical tests based on primer-initiated amplification of specific nucleic acid sequences achieve high levels of sensitivity and specificity. Despite these desirable characteristics, these tests have not reached their full potential because their complexity and expense limit their usefulness to centralized
Michael D Swartz et al.
PloS one, 8(1), e53475-e53475 (2013-02-02)
Folate metabolism, with its importance to DNA repair, provides a promising region for genetic investigation of lung cancer risk. This project investigates genes (MTHFR, MTR, MTRR, CBS, SHMT1, TYMS), folate metabolism related nutrients (B vitamins, methionine, choline, and betaine) and
Steven H Zeisel
Nutrition reviews, 64(2 Pt 1), 77-79 (2006-03-16)
Betaine supplementation in humans has been shown to lower plasma homocysteine concentrations in modestly hyperhomocysteinemic patients. Betaine treatment is associated with increased plasma low-density-lipoprotein (LDL) cholesterol, suggesting that although betaine supplementation lowers homocysteine, a risk factor for cardiovascular disease, changes
Linda M Reis et al.
Molecular vision, 20, 836-842 (2014-06-19)
Congenital cataracts occur in 3-4 per 10,000 live births and account for 5% to 20% of pediatric blindness worldwide. With more than 37 genes known to be associated with isolated congenital cataract, whole exome sequencing (WES) was recently introduced as
Kenneth Day et al.
PloS one, 9(10), e111756-e111756 (2014-10-31)
Current target enrichment systems for large-scale next-generation sequencing typically require synthetic oligonucleotides used as capture reagents to isolate sequences of interest. The majority of target enrichment reagents are focused on gene coding regions or promoters en masse. Here we introduce
Thomas H Ambrosi et al.
eLife, 10 (2021-07-20)
Skeletal stem and progenitor cell populations are crucial for bone physiology. Characterization of these cell types remains restricted to heterogenous bulk populations with limited information on whether they are unique or overlap with previously characterized cell types. Here we show
Jiangshan Wang et al.
MethodsX, 8, 101586-101586 (2021-11-30)
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused unprecedented damage to the global economy. Diagnostic testing is a key factor in limiting virus transmission and safeguarding public health. We present the fabrication process of
Line Rørbæk Olsen et al.
Analytical and bioanalytical chemistry, 407(8), 2149-2158 (2014-11-19)
Desorption electrospray ionization (DESI) mass spectrometry (MS) imaging was used to image locusts dosed with the antihistamine drug terfenadine. The study was conducted in order to elucidate a relatively high elimination rate of terfenadine from the locust hemolymph. In this
Paul G Thomes et al.
Biochemical pharmacology, 96(1), 30-38 (2015-05-02)
Alcoholic liver disease (ALD) is a major healthcare challenge worldwide. Emerging evidence reveals that ethanol administration disrupts the intestinal epithelial tight junction (TJ) complex; this defect allows for the paracellular translocation of gut-derived pathogenic molecules to reach the liver to
Fabio Concetti et al.
European journal of human genetics : EJHG, 23(2), 267-270 (2014-06-05)
Recent evidence demonstrated a relevant role of adenosine deaminase (ADA) in replicative senescence of T cells through its capacity to modulate telomerase activity (TA). Herein, we tested the impact of the functional polymorphism ADA rs73598374:G>A (c.22G>A, p.Asp8Asn) on telomere biology
D S Gill et al.
Journal of clinical pathology, 44(3), 243-245 (1991-03-01)
Plasma histamine concentrations were measured using a commercially available monoclonal antibody radioimmunoassay in 38 patients with nephrotic syndrome, end stage renal failure, those receiving haemodialysis, and those receiving continuous ambulatory peritoneal dialysis to determine whether histamine may mediate damage to
Rong Hu et al.
Langmuir : the ACS journal of surfaces and colloids, 29(11), 3773-3779 (2013-02-22)
In this work, we demonstrate a convenient, efficient, and environmentally benign strategy to achieving antimicrobial and antiadhesive purposes using a silver-zwitterion nanocomposite. The synthesis of the nanocomposite relies on loading zwitterionic polymer brushes with Ag(+) precursor ions, followed by their
L L Qi et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 128(3), 477-488 (2015-01-13)
The rust resistance gene R 2 was reassigned to linkage group 14 of the sunflower genome. DNA markers linked to R 2 were identified and used for marker-assisted gene pyramiding in a confection type genetic background. Due to the frequent
W Henke et al.
Nucleic acids research, 25(19), 3957-3958 (1997-10-10)
Betaine improves the co-amplification of the two alternatively spliced variants of the prostate-specific membrane antigen mRNA as well as the amplification of the coding cDNA region of c-jun. It is suggested that betaine improves the amplification of these genes by
Pedro Fernández-Soto et al.
PLoS neglected tropical diseases, 8(9), e3126-e3126 (2014-09-05)
Human schistosomiasis, mainly due to Schistosoma mansoni species, is one of the most prevalent parasitic diseases worldwide. To overcome the drawbacks of classical parasitological and serological methods in detecting S. mansoni infections, especially in acute stage of the disease, development
D S Raj et al.
Blood purification, 18(2), 97-102 (2000-06-06)
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.
Kuan-Hui Hsu et al.
Current eye research, 40(3), 267-273 (2014-05-17)
To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness. Profiles of the release of osmoprotectant betaine and moisturizing agent dexpanthenol from senofilcon
Jan H Lui et al.
Cell, 184(2), 489-506 (2020-12-19)
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell types. Here we examine how specific transcriptomic types of mouse prefrontal cortex
Yuhua Li et al.
BMC infectious diseases, 20(1), 319-319 (2020-05-03)
Trichomoniasis resulting from Trichomonas vaginalis (T. vaginalis) has been considered as a commonly seen disease with the transmission way of sex. At present, the detection methods of T. vaginalis mainly include wet mount microscopy, culture, PCR, immunofluorescence and ELISA. However
Wei Ying et al.
Cell metabolism, 29(2), 457-474 (2019-01-01)
The nature of obesity-associated islet inflammation and its impact on β cell abnormalities remains poorly defined. Here, we explore immune cell components of islet inflammation and define their roles in regulating β cell function and proliferation. Islet inflammation in obese
Roger C Diehl et al.
Biochemistry, 52(35), 5997-6010 (2013-08-06)
To quantify interactions of the osmolyte l-proline with protein functional groups and predict their effects on protein processes, we use vapor pressure osmometry to determine chemical potential derivatives dμ2/dm3 = μ23, quantifying the preferential interactions of proline (component 3) with
Kristina M Cammen et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 150-158 (2014-12-03)
In coastal marine ecosystems, neurotoxins produced by harmful algal blooms (HABs) often result in large-scale mortality events of many marine species. Historical and frequent exposure to HABs therefore may provide a strong selective pressure for adaptations that result in toxin
Dong Hwan Kim et al.
International journal of oncology, 45(3), 1250-1256 (2014-06-28)
Betaine is an important human nutrient obtained from various foods and studies in animals and humans have provided results suggesting their pathogenesis of various chronic diseases and points to a role in risk assessment and disease prevention. However, the molecular
Diet quality and telomere length in older Australian men and women
Milte CM, et al.
European Journal of Nutrition, 57(1), 363-372 (2018)
Yan-Jie Tian et al.
The British journal of nutrition, 111(9), 1594-1601 (2014-02-11)
Recent evidence shows that excess nicotinamide can cause epigenetic changes in developing rats. The aim of the present study was to investigate the effects of maternal nicotinamide supplementation on the fetus. Female rats were randomised into four groups fed a
Goodwin G Jinesh et al.
Scientific reports, 10(1), 12371-12371 (2020-07-25)
MYO18B has been proposed to contribute to the progression of hepatocellular carcinoma (HCC). However, the signals that govern MYO18B transcription are not known. Here we show that, a network of C19MC miRNA-520G, IFN-γ, CEBPB and p53 transcriptional-defects promote MYO18B mRNA
Arpita Roychoudhury et al.
Biological chemistry, 394(11), 1465-1474 (2013-09-12)
Compatible solutes are small, uncharged, zwitter ionic, osmotically active molecules produced and accumulated by microorganisms inside their cell to counteract different kinds of environmental stress. They enhance protein stability without interfering with the metabolic pathways even at molar concentrations. In
Shuai Gao et al.
Nature cell biology, 20(6), 721-734 (2018-05-29)
The development of the digestive tract is critical for proper food digestion and nutrient absorption. Here, we analyse the main organs of the digestive tract, including the oesophagus, stomach, small intestine and large intestine, from human embryos between 6 and
Simon Kluters et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 37-46 (2015-11-02)
Cation exchange chromatography (CEX) is an integral part of many downstream processes for monoclonal antibodies (mAbs). However, in some cases CEX methods with standard mobile phase conditions do not lead to a sufficient removal of soluble antibody aggregates. The addition
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