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Hans Maaswinkel et al.
Behavioural brain research, 234(2), 365-374 (2012-07-18)
Behavioral changes in zebrafish induced by acute administration of buspirone have been interpreted to be the result of reduced anxiety. The purpose of the current study was to determine whether the effects of short-term and mid-term habituation to an open
Bing Li et al.
Neuroscience letters, 541, 227-232 (2013-02-19)
An increased vulnerability to pain complaints, along with a simultaneous increase in experimental pain thresholds, shows the paradoxical phenomenon of pain perception in depressive patients. Clomipramine, a tricyclic antidepressant, could also ameliorate syndromes in chronic pain patients. However, few studies
Markus Lagus et al.
Journal of neurogenetics, 26(3-4), 397-412 (2012-07-13)
Disturbances in sleep are encountered in the majority of patients with depressive disorder. To elucidate the molecular mechanisms behind this relationship, we examined gene expression changes in a rodent model for disturbed sleep and depression. The animals were treated with
Delphine Oudiette et al.
Consciousness and cognition, 21(3), 1129-1140 (2012-06-01)
To test whether mental activities collected from non-REM sleep are influenced by REM sleep, we suppressed REM sleep using clomipramine 50mg (an antidepressant) or placebo in the evening, in a double blind cross-over design, in 11 healthy young men. Subjects
Serotonin reuptake inhibitor treatment of obsessive-compulsive symptoms in clozapine-medicated schizophrenia.
Chittaranjan Andrade
The Journal of clinical psychiatry, 73(11), e1362-e1364 (2012-12-12)
Joan Santamaria-Cano
Revista de neurologia, 54 Suppl 3, S25-S30 (2012-05-19)
Narcolepsy is an emblematic, unique disease within sleep disorders that is characterised by excessive daytime sleepiness, cataplexy and other abnormal manifestations of REM sleep. In the last 14 years truly spectacular progress has been made in our knowledge of this
Ilia D Kostadinov et al.
Folia medica, 54(4), 69-77 (2013-02-28)
Tricyclic antidepressants are used in the treatment of various pain syndromes. The antidepressant clomipramine inhibits predominantly the reuptake of serotonin in the central nervous system. The mechanism of its analgesic effect is not fully understood. The AIM of the present
Steffi Weidt et al.
Praxis, 102(14), 857-864 (2013-07-05)
Obsessive-compulsive disorder (OCD) is common and associated with marked impairment and reduced quality of life. In the general practitioner's office as well as in the specialist's consultation, patients with OCD usually present intrusive thoughts (obsessions) and repetitive behaviours (compulsions). OCD
Sule Ayla et al.
Journal of pediatric hematology/oncology, 36(1), 37-44 (2012-11-07)
Neuroblastoma is a severe pediatric tumor characterized by poor prognosis. Identification of novel molecular targets and diversion of investigations on new drug trials is mandatory for cancer therapy. In this study, vinorelbine tartrate, lithium chloride, clomipramine, and medroxyprogesterone acetate are
Qiong Liu et al.
Journal of affective disorders, 141(2-3), 367-372 (2012-06-05)
Because there is evidence that certain neurotrophic factors are involved in depression and the mechanism of antidepressant treatment, it is hypothesized that neurotrophic factors may also play a functional role in the etiology of depression and treatment. Glial cell line-derived
Bonnie A Merchant et al.
Journal of molecular graphics & modelling, 38, 1-12 (2012-10-20)
The dopamine transporter (DAT) facilitates the regulation of synaptic neurotransmitter levels. As a target for therapeutic and illicit psycho-stimulant drugs like antidepressants and cocaine, DAT has been studied intensively. Despite a wealth of mutational and physiological data regarding DAT, the
Naomi A Fineberg et al.
The Australian and New Zealand journal of psychiatry, 47(2), 121-141 (2012-11-06)
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated with a significant degree of functional disability and poor quality of life. Pharmacotherapy may have a substantial impact on the course and outcome of OCD. We review the evidence supporting available strategies
Deborah S Kreiss et al.
Pharmacology, biochemistry, and behavior, 104, 119-124 (2013-01-22)
Obsessive Compulsive Disorder (OCD) is characterized by recurrent, anxiety-producing thoughts accompanied by unwanted, overwhelming urges to perform ritualistic behaviors. Pharmacological treatments for this disorder (serotonin uptake inhibitors) are problematic because there is a 6-8 week delayed onset and half of
Hanan Sayed Mohamed Farghaly et al.
Nitric oxide : biology and chemistry, 27(2), 88-94 (2012-05-16)
The analgesic effect of acute i.p. administration of amitriptyline (norepinepherine and serotonin reuptake inhibitor), clomipramine (serotonin reuptake inhibitor) and desipramine (norepinepherine reuptake inhibitor) was studied in chronic constriction injury (CCI) model of sciatic nerve in rats and mRNA and protein
P M Pitychoutis et al.
Neuroscience, 210, 152-167 (2012-03-24)
It is well established that women experience major depression at roughly twice the rate of men. Interestingly, accumulating clinical and experimental evidence shows that the responsiveness of males and females to antidepressant pharmacotherapy, and particularly to tricyclic antidepressants (TCAs), is
Lisa M Johansen et al.
Science translational medicine, 7(290), 290ra89-290ra89 (2015-06-05)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical resource for potential
Zsolt Kovács et al.
Brain research bulletin, 89(3-4), 102-107 (2012-08-14)
Recently it was revealed that the absence-like epileptic activity of the WAG/Rij (Wistar Albino Glaxo/Rijswijk) rat is associated with depression-like behavioural symptoms. Whether these depressive-like symptoms are accompanying epileptic activity (manifested in spike-wave discharges, SWDs, in the EEG) or whether
Nicola Luigi Bragazzi et al.
Critical reviews in eukaryotic gene expression, 22(3), 197-203 (2012-11-13)
Langmuir-Blodgett (LB) technology was used to build a high-sensitivity enzyme-based biosensor for medical purposes. Recombinant fungal laccase from Rigidoporous lignosus, as previously described, was used to catalyze a widely used antidepressant in a micromolar range, namely, clomipramine. The topological properties
Pingfu Feng et al.
Journal of psychiatric research, 47(5), 579-585 (2013-02-21)
Depression is associated with structural and neurochemical changes in limbic structures, including the hippocampus, that control emotion and mood. Structural abnormalities such as decrease in hippocampal cell proliferation, neurogenesis and hippocampal volume, and loss of neurons and glial cells have
J Gallego et al.
Revue des maladies respiratoires, 29(3), 430-434 (2012-03-24)
Drug hypersensitivity (DRESS syndrome) is a rare disorder with diverse systemic and visceral manifestations. Pulmonary involvement is uncommon and is mainly characterized by eosinophilic infiltration. We report a case of DRESS syndrome induced by clomipramine with predominant pulmonary involvement.
M Harvey et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 13-19 (2014-01-09)
Intravenous lipid emulsion (ILE) has been shown to ameliorate toxicity from lipophilic xenobiotics, attributed in part through sequestration to circulating lipid droplets (sink). We postulated additional benefit with plasma exchange therapy undertaken subsequent to lipid injection, hypothesising enhanced blood carriage
Aleksander Targoński et al.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 65(1), 44-47 (2012-07-26)
Premature ejaculation is the most common sexual dysfunction in men. Its prevalence rate in Europe and in United States is estimated to be between 20% and 30%. The diagnosis of premature ejaculation is based on three main criteria: increased intravaginal
M Komorowski et al.
Neuroscience, 223, 152-162 (2012-08-09)
Despair-related withdrawal behaviors are common symptoms of major depression (MD) and can be ascribed to a loss or absence of former rewarding events. Extinction of negatively reinforced escape behavior in the Morris Water Maze has been shown to induce despair-like
Romy Hurwitz et al.
The Cochrane database of systematic reviews, 3(3), CD008372-CD008372 (2012-03-16)
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders, ranging in severity and characterised by early onset of delay and deviance in the development of social interaction, and verbal and nonverbal communication. ASD is associated with restricted and/or
[To identify and treat obsessive-compulsive disorders: an overview].
Ulrich Voderholzer et al.
MMW Fortschritte der Medizin, 155(15), 37-39 (2013-11-15)
Hellen N Kariuki et al.
The Pan African medical journal, 12, 28-28 (2012-08-15)
Pethidine, an opioid analgesic is used for pain management. Clomipramine a tricyclic antidepressant primarily used for mood management is also used to treat pain. The objective of this study was to investigate the potentiation of the analgesic effects of sub-threshold
Xiaoyan Wang et al.
Journal of proteome research, 11(12), 6223-6230 (2012-11-01)
The protective effects of St John's Wort extract (SJ), ginsenosides (GS), and clomipramine (CPM) on chronic unpredictable mild stress (CUMS)-induced depression in rats were investigated by using a combination of behavioral assessments and metabonomics. Metabonomic analyses were performed using gas
Carla Nasca et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4804-4809 (2013-02-06)
Epigenetic mechanisms are involved in the pathophysiology of depressive disorders and are unique potential targets for therapeutic intervention. The acetylating agent L-acetylcarnitine (LAC), a well-tolerated drug, behaves as an antidepressant by the epigenetic regulation of type 2 metabotropic glutamate (mGlu2)
Koichi Suehiro et al.
Life sciences, 92(23), 1138-1144 (2013-05-09)
In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analgesics in rats
Diagnosis and treatment of canine separation anxiety and the use of clomipramine hydrochloride (clomicalm).
D F Horwitz
Journal of the American Animal Hospital Association, 36(2), 107-109 (2000-03-24)
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