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C5483
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Sriniwas Sriram et al.
Investigative ophthalmology & visual science, 54(13), 8214-8223 (2013-11-28)
Transforming growth factor β1 (TGFβ1), TGFβ receptor (TGFβR2), and connective tissue growth factor (CTGF) are key regulators of fibrosis in the cornea and in other tissues, including liver, skin, and kidney. We developed an antifibrotic treatment targeting these three critical
Angio-Seal hopes for antegrade puncture require better evidence.
J-B Ricco et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 48(2), 226-227 (2014-06-22)
Samantha Bonnel et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 31(1), 36-40 (2015-01-20)
To evaluate the visualization and depth of the demarcation line with anterior segment optical coherence tomography (AS-OCT) after iontophoresis-assisted transepithelial corneal collagen cross-linking (CXL). This prospective, consecutive, single center, non-randomized clinical study involved 15 eyes of 12 patients with keratoconus
Saw Marlar et al.
Biochimica et biophysica acta, 1838(10), 2404-2411 (2014-06-21)
Micropatterning enabled semiquantitation of basolateral proteins in lateral and basal membranes of the same cell. Lateral diffusion coefficients of basolateral aquaporin-3 (AQP3-EGFP) and EGFP-AQP4 were extracted from "lateral" and "basal" membranes using identical live-cell imaging and k-space Image Correlation Spectroscopy
Zhongcheng Gong et al.
Biomedical materials (Bristol, England), 5(5), 055005-055005 (2010-09-10)
The objective was to investigate synovium-derived stromal cells (SDSCs) coupled with chitosan/collagen type I (CS/COL-I) scaffolds for cartilage engineering. CS/COL-I scaffolds were fabricated through freeze-drying and cross-linked by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. SDSCs were isolated from synovium and cultured onto CS/COL-I scaffolds, constructs
Microfocused ultrasound with visualization and fillers for increased neocollagenesis: clinical and histological evaluation.
Gabriela Casabona et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 40 Suppl 12, S194-S198 (2014-11-25)
Alex S Huang et al.
Investigative ophthalmology & visual science, 54(7), 4813-4820 (2013-06-08)
In situ 2-photon excitation fluorescence (TPEF) of the human trabecular meshwork (TM) reveals beams of heterogeneous autofluorescence (AF) comprising high intensity fluorescent fibers (AF-high) on a background of lower intensity fluorescence (AF-low). To determine the sources of this AF heterogeneity
Roger Svensson et al.
Swedish dental journal, 37(2), 71-77 (2013-08-21)
The aim of this retrospective study was to assess the frequency of postoperative bleeding in patients on warfarin after tooth removal followed by a complete soft tissue closure of the surgical site. A total of 124 consecutive patients, 69 males
Leonardo Mastropasqua et al.
Investigative ophthalmology & visual science, 55(4), 2526-2533 (2014-03-29)
The aim of this study is to investigate modifications in human cadaver corneas after different crosslinking procedures, including standard epi-off treatment, iontophoresis imbibition, and different exposure to ultraviolet A (UVA) sources (30 minutes at 3 mW and 9 minutes at
Dividutta Das et al.
The Journal of heart valve disease, 22(5), 621-630 (2014-01-05)
Aortic valve stenosis is a major cause of valve replacement, particularly in the elderly. TGF-beta1 is upregulated in stenotic valves and induces calcification and collagen synthesis in cultured valve interstitial cells. It has been shown previously that TGF-beta1 increases reactive
Christopher M Runyan et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(5), 1000-1000 (2014-04-20)
"Allograft revitalization" is a process in which cadaveric bone is used to generate well-vascularized living bone. We had previously found that porcine allograft hemimandibles filled with autologous adipose-derived stem cells (ASCs) and recombinant human bone morphogenetic protein-2-soaked absorbable collagen sponge
Xiaofeng Zhu et al.
Zoological science, 30(12), 1032-1037 (2013-12-11)
Autologous bone marrow-derived mesenchymal stem cell (BMSCs)-based therapies show great potential in regenerative medicine. However, long-term storage and preservation of BMSCs for clinical use is still a great clinical challenge. The present study aimed to analyze the effect of long-term
Hisayo Yamaoka et al.
Plastic and reconstructive surgery, 134(1), 50e-58e (2014-07-17)
Injectable collagen is often used for treatment of wrinkles or scars in cosmetic surgery. However, it is degraded within a short period after subcutaneous injection. The authors aimed to achieve a long-lasting effect of the filler with a new collagenase
Yuxin Pang et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 34(6), 716-724 (2015-01-27)
To assess the effectiveness of violate oil from Blumea Balsamifera (L.) DC. leaves (BB oil) on wound healing in mice. Undiluted BB oil and its diluted solutions with olive oil to 1/5 and 1/10 to yield BB oil1/5 and BB
M V Ghica et al.
Die Pharmazie, 68(5), 340-348 (2013-06-28)
An important aspect to be considered in the healing of acute or chronic cutaneous wounds is the associated potential infection management. Collagen, the most abundant protein of the extracellular matrix, with proven properties in wounds healing and tissues regeneration, is
Benjamin I Binder-Markey et al.
Frontiers in physiology, 11, 293-293 (2020-05-05)
The passive load bearing properties of muscle are poorly understood partly due to challenges in identifying the connective tissue structures that bear loads. Prior attempts to correlate passive mechanical properties with collagen content (often expressed as a mass ratio and
An unusual finding in a man with GERD.
Garrett M Harp et al.
Gastroenterology, 147(2), e7-e9 (2014-06-29)
Yuzhu Hou et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 130-138 (2014-06-08)
The high temperature requirement A1 (HTRA1) is a potent protease involved in many diseases, including rheumatoid arthritis (RA). However, the regulatory mechanisms that control HTRA1 expression need to be determined. In this study, we demonstrated that IFN-γ significantly inhibited the
Integrin activation or alpha9 expression allows retinal pigmented epithelial cell adhesion on Bruch?s membrane in wet age-related macular degeneration
Afshari FT, et al.
Brain, 133(2), 448-464 (2010)
Marco Esposito et al.
European journal of oral implantology, 6(2), 169-179 (2013-08-09)
To compare the clinical effectiveness of two implant systems: Way Milano and Kentron (Geass, Pozzuolo del Friuli, UD, Italy). A total of 64 patients requiring at least two single crowns or partial fixed dental prostheses supported by a maximum of
Rare autosomal recessive cardiac valvular form of Ehlers-Danlos syndrome results from mutations in the COL1A2 gene that activate the nonsense-mediated RNA decay pathway
Schwarze U, et al.
American Journal of Human Genetics, 74(5), 917-930 (2004)
Justin W Griffin et al.
The Journal of bone and joint surgery. American volume, 95(23), 2144-2151 (2013-12-07)
When possible, direct repair remains the current standard of care for the repair of peripheral nerve lacerations. In large nerve gaps, in which direct repair is not possible, grafting remains the most viable option. Nerve scaffolds include autologous conduits, artificial
Paolo Vinciguerra et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(11), 746-753 (2014-11-07)
To report initial clinical results of transepithelial corneal collagen cross-linking with iontophoresis (I-CXL). Twenty eyes of 20 patients diagnosed as having progressive keratoconus who underwent I-CXL were included in this prospective non-randomized clinical study. Corrected distance visual acuity (CDVA), spherical
Ken Nakata et al.
Clinical calcium, 23(12), 1731-1739 (2013-12-03)
Meniscus is one of the most important tissues in knee joint from the biomechanical point of view. Meniscus injury is well known to cause osteoarthritis. At moment, there is a limitation of operative repair procedure especially for the meniscus injury
James R W Conway et al.
Nature reviews. Cancer, 14(5), 314-328 (2014-04-18)
Integrating biological imaging into early stages of the drug discovery process can provide invaluable readouts of drug activity within complex disease settings, such as cancer. Iterating this approach from initial lead compound identification in vitro to proof-of-principle in vivo analysis
Ahmad Kutkut et al.
Journal of the International Academy of Periodontology, 15(4), 113-124 (2013-12-25)
The aim of this report was to clinically and radiographically evaluate changes to the hard and soft tissues around implants placed in extraction sockets grafted with medical grade calcium sulfate hemihydrate (MGCSH) mixed with platelet-rich plasma (PRP) and a collagen
S Bhattacharya et al.
Journal of biomedical nanotechnology, 10(5), 811-819 (2014-04-17)
Controlled size, shape and dispersibility of superparamagnetic iron oxide nanoparticles (SPIONs), has been achieved in a protein-polymer colloidal dispersion. Stable ferrofluid (FF) is synthesized in an aqueous medium of collagen, bovine serum albumin and poly(vinyl) alcohol that equilibrates with time
Farhad Hafezi et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(7), 498-500 (2014-06-04)
To report the long-term clinical outcome of a patient diagnosed as having Terrien marginal degeneration (TMD) who was subjected to corneal collagen cross-linking (CXL) with ultraviolet-A and riboflavin in both eyes. Topographical changes were assessed by high-resolution Scheimpflug imaging and
He Ren et al.
Cancer letters, 354(1), 172-180 (2014-08-19)
The aim of this study is to investigate the regulatory mechanism of leptin receptors (Ob-R) in pancreatic cancer. We found that the over-expression of hypoxia inducible factor (HIF-1)α and hypoxia up-regulated the expression of Ob-R in pancreatic cancer cells. When
Olivier Richoz et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 842-845 (2014-01-10)
To investigate the effect of fluorescein on the antimicrobial efficacy of photoactivated riboflavin in corneal collagen cross-linking (CXL) in vitro. The ultraviolet light-A (UVA) absorption by fluorescein and riboflavin in different concentrations was analyzed with a spectrophotometer. The killing rate
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