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Zhi-Min Wang et al.
Molecular medicine reports, 12(5), 6815-6820 (2015-09-04)
Several biological properties of icariin have been identified, including its anticancer effect. However, the potential mechanisms underlying the effect of icariin on HepG2 hepatocellular carcinoma cells remain to be elucidated. The aim of the present study was to examine the
Marcin Andrzej Lipiec et al.
Development (Cambridge, England), 147(16) (2020-07-18)
Neuronal phenotypes are controlled by terminal selector transcription factors in invertebrates, but only a few examples of such regulators have been provided in vertebrates. We hypothesised that TCF7L2 regulates different stages of postmitotic differentiation in the thalamus, and functions as
Aijun Wang et al.
Stem cells translational medicine, 4(6), 659-669 (2015-04-26)
Myelomeningocele (MMC)-commonly known as spina bifida-is a congenital birth defect that causes lifelong paralysis, incontinence, musculoskeletal deformities, and severe cognitive disabilities. The recent landmark Management of Myelomeningocele Study (MOMS) demonstrated for the first time in humans that in utero surgical
Choong-Hwan Cha et al.
Annals of laboratory medicine, 34(6), 426-432 (2014-11-05)
The presence of significant dysplasia in bone marrow (BM) aspirates helps to distinguish between hypocellular myelodysplastic syndrome (hMDS) and aplastic anemia (AA). Occasionally, diluted BM aspirates make it difficult to recognize dysplastic changes and can also negatively affect the detection
Yin-Kai Chen et al.
PloS one, 10(3), e0119831-e0119831 (2015-03-21)
Robo4 is involved in hematopoietic stem/progenitor cell homeostasis and essential for tumor angiogenesis. Expression of Robo4 was recently found in solid tumors and leukemia stem cells. However, the clinical implications of Robo4 expression in patients with acute myeloid leukemia (AML)
Martin J Edelman et al.
Human pathology, 45(9), 1893-1899 (2014-07-19)
GP88 (progranulin) is a growth and survival factor implicated in tumorigenesis and drug resistance. Previous studies showed that GP88 was expressed in breast cancer tissue in inverse correlation with survival. This study evaluates GP88 tissue expression in localized/locally advanced lung
Anja Kafka et al.
International journal of molecular sciences, 15(6), 10635-10651 (2014-06-17)
The susceptibility of brain to secondary formation from lung cancer primaries is a well-known phenomenon. In contrast, the molecular basis for invasion and metastasis to the brain is largely unknown. In the present study, 31 brain metastases that originated from
Sajal Samanta et al.
PloS one, 6(12), e28169-e28169 (2011-12-14)
Using a lectin, Achatinin-H, having preferential specificity for glycoproteins with terminal 9-O-acetyl sialic acid derivatives linked in α2-6 linkages to subterminal N-acetylgalactosamine, eight distinct disease-associated 9-O-acetylated sialoglycoproteins was purified from erythrocytes of visceral leishmaniaisis (VL) patients (RBC(VL)). Analyses of tryptic
A B Kay et al.
The British journal of dermatology, 172(5), 1294-1302 (2014-12-20)
The mechanism of wealing in chronic spontaneous urticaria (CSU) is largely unknown. We previously demonstrated increased expression of T-helper 2 [interleukin (IL)-4 and IL-5] cytokines in skin biopsies from CSU. This suggested that Th2-initiating cytokines [IL-33, IL-25 and thymic stromal
Larissa Nelson et al.
Cartilage, 5(4), 203-214 (2015-06-13)
Osteoarthritis (OA) is a debilitating disease affecting more than 4 million people in the United Kingdom. Despite its prevalence, there is no successful cell-based therapy currently used to treat patients whose cartilage is deemed irrecoverable. The present study aimed to
Hyun Yang et al.
Reproductive biology and endocrinology : RB&E, 9, 28-28 (2011-03-03)
Human endometrium resists embryo implantation except during the 'window of receptivity'. A change in endometrial gene expression is required for the development of receptivity. Uterine calbindin-D28k (CaBP-28k) is involved in the regulation of endometrial receptivity by intracellular Ca2+. Currently, this
Luigi Strizzi et al.
Oncotarget, 6(33), 34071-34086 (2015-10-16)
Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatment of C8161
Nurain Ismail et al.
Molecular reproduction and development, 82(6), 463-474 (2015-05-29)
The consistency of the cervical mucus changes with the reproductive cycle, which we hypothesized involved changing levels of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC), and cyclic adenosine mono-phosphate (cAMP). We therefore measured the abundance of each in the
Matúš Skyba et al.
Journal of plant physiology, 169(10), 955-964 (2012-05-12)
Extreme low temperatures cause plants multiple stresses, among which oxidative stress is presumed to be the major component affecting the resultant recovery rate. Plants of Hypericum perforatum L., which are known especially for the photodynamic activities of hypericins capable of
Bruno Lopes dos Santos-Lobato et al.
Arquivos de neuro-psiquiatria, 73(9), 779-783 (2015-09-10)
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson's disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of
Z Majercikova et al.
Endocrine regulations, 46(4), 217-223 (2012-11-07)
The aim of the present study was to introduce a new approach of the light microscopic immunohistochemical triple-staining enabling to study the differences in the activity of at least two different phenotypes of neurons on the same histological section. For
Young-Sam Cho et al.
Molecular medicine reports, 12(2), 1796-1802 (2015-04-22)
Ulinastatin is a urinary trypsin inhibitor, originally extracted and purified from human urine. Ulinastatin has cytoprotective effects against ischemic injury in several organs. In the present study, the neuroprotective effects of ulinastatin following ischemic cerebral injury in the hippocampus of
Young-Sam Cho et al.
Molecular medicine reports, 12(2), 2563-2569 (2015-05-09)
Neurogenic lower urinary tract dysfunction (NLUTD) is a major problem in patients with various neurological disorders, and may result in debilitating symptoms and serious complications, including chronic renal failure and recurrent urinary tract infections. Clinically, stroke is associated with voiding
Amparo Novejarque et al.
Frontiers in neuroanatomy, 5, 54-54 (2011-10-19)
Rodents constitute good models for studying the neural basis of sociosexual behavior. Recent findings in mice have revealed the molecular identity of the some pheromonal molecules triggering intersexual attraction. However, the neural pathways mediating this basic sociosexual behavior remain elusive.
Giuseppina Cantarella et al.
Brain : a journal of neurology, 138(Pt 1), 203-216 (2014-12-05)
Alzheimer's disease is one of the most common causes of death worldwide, with poor treatment options. A tissue landmark of Alzheimer's disease is accumulation of the anomalous protein amyloid-β in specific brain areas. Whether inflammation is an effect of amyloid-β
Carmen Ranftler et al.
Methods in molecular biology (Clifton, N.J.), 931, 437-447 (2012-10-03)
Detailed insight into the fine structure and 3D-architecture of the complex and dynamic compartments of the endocytic system is essential for a morpho-functional analysis of retrograde traffic from the cell surface to different intracellular destinations. Here, we describe a cytochemical
Varsha Meghnani et al.
The international journal of biochemistry & cell biology, 57, 54-62 (2014-10-15)
Recent studies have suggested that the receptor for advanced glycation end products (RAGE) participates in melanoma progression by promoting tumor growth. However, the mechanisms of RAGE activation in melanoma tumors are not clearly understood. To get deeper insights into these
Guo-Biao Liang et al.
Molecular medicine reports, 12(2), 2577-2583 (2015-05-06)
Chronic allograft nephropathy (CAN) is a major cause of graft loss following kidney transplantation and may result from the interactions of various immune and non-immune factors. The aim of the present study was to establish an in vitro model of
Itaru Omoto et al.
Anticancer research, 34(6), 2727-2733 (2014-06-13)
Ghrelin, an orexigenic peptide, is primarily produced and secreted by the gastrointestinal tract. As far as we are aware of, there is no evidence of ghrelin expression in esophageal squamous cell carcinoma (ESCC). Two hundred and ten patients with ESCC
Yu-Jen Jou et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 121-129 (2014-05-28)
Oral squamous cell carcinoma (OSCC) shows low 5-year survival; early treatment greatly reduces mortality and morbidity. Saliva is a non-invasive sample, with good potential to discover biomarkers for early detection. NanoLC-MS/MS served to analyze saliva proteome from control subjects (n=35)
Camile Garcia Blumer et al.
BJU international, 109(2), 259-265 (2011-05-20)
To assess the effect of varicocele on sperm DNA integrity, mitochondrial activity, lipid peroxidation and acrosome integrity. In all, 30 patients with a clinically diagnosed varicocele of grade II or III and 32 men without a varicocele were evaluated for
Kyoung-Woon Kim et al.
The American journal of pathology, 185(11), 3011-3024 (2015-09-13)
This study determined the effect of type 17 helper T-cell (Th17) cytokines on osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor activator of NF-κB ligand (RANKL) was determined in synovial tissue, fibroblast-like synoviocytes (FLSs), and synovial fluids
María Rivoira et al.
Biochimica et biophysica acta, 1852(3), 386-394 (2014-12-03)
The aim was to determine the intestinal Ca²⁺ absorption in type I diabetic rats after different times of STZ induction, as well as the gene and protein expression of molecules involved in both the transcellular and paracellular Ca²⁺ pathways. The
Lars Zimmermann et al.
Neuroscience letters, 489(2), 89-93 (2010-12-09)
Palisade endings are found in the extraocular muscles (EOMs) of almost every mammalian species, including primates. These nerve specializations surrounding the muscle fiber insertion have been postulated to be the proprioceptors of the EOMs. However, it was recently demonstrated that
Kitti B Kovács et al.
Thrombosis research, 135(4), 718-726 (2015-01-27)
Protein C (PC) is a major anticoagulant and numerous distinct mutations in its coding gene result in quantitative or qualitative PC deficiency with high thrombosis risk. Homozygous or compound heterozygous PC deficiency usually leads to life-threatening thrombosis in neonates. The
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