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D2438
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Poonam Tyagi et al.
PloS one, 10(3), e0121313-e0121313 (2015-03-27)
Curcumin, an important constituent of turmeric, is known for various biological activities, primarily due to its antioxidant mechanism. The present study focused on the antibacterial activity of curcumin I, a significant component of commercial curcumin, against four genera of bacteria
Wenwu Wang et al.
Oncology reports, 34(4), 2115-2125 (2015-08-05)
The aim of the present study was to examine the relationship between DR4 methylation status and gene expression and to determine whether DR4 methylation status affects TRAIL-induced apoptosis in lung squamous carcinoma cells. MSP, RT-PCR and western blot analysis were
Helene Tuft Stavnes et al.
American journal of clinical pathology, 142(1), 51-57 (2014-06-14)
We previously described the overexpression of APOA1 and GPX3 in ovarian/peritoneal serous carcinoma compared with breast carcinoma effusions using gene expression array analysis. The objective of the present study was to validate this finding and to analyze the association between
Chun-Hui Wang et al.
ACS applied materials & interfaces, 7(28), 15263-15276 (2015-06-26)
The objective of this study was to investigate whether surface coating with graphene could enhance the surface bioactivation of PET-based artificial ligaments to accelerate graft-to-bone healing after anterior cruciate ligament reconstruction. In an in vitro study, the proliferation of MC3T3-E1
Satyaki Sengupta et al.
The Journal of biological chemistry, 290(23), 14462-14475 (2015-04-24)
The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in development through their regulation of genes involved in cell fate. Multiple regulatory pathways impact RB function, including the ubiquitin-proteasome system with deregulated RB destruction frequently associated
Nadine J Ortner et al.
Nature communications, 5, 3897-3897 (2014-06-20)
Cav1.2 and Cav1.3 are the main L-type Ca(2+) channel subtypes in the brain. Cav1.3 channels have recently been implicated in the pathogenesis of Parkinson's disease. Therefore, Cav1.3-selective blockers are developed as promising neuroprotective drugs. We studied the pharmacological properties of
Nabanita Chatterjee et al.
Journal of leukocyte biology, 96(2), 325-336 (2014-04-04)
The use of live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites has begun to emerge as a potential new approach in medicinal research to deliver biologically active entities. Thus, advancing our knowledge of such microbe-mediated therapy
Thomas J Musielak et al.
Plant reproduction, 28(3-4), 161-169 (2015-10-12)
The optical brightener SCRI Renaissance 2200 can be used as versatile dye to study various aspects of plant reproduction by confocal laser scanning microscopy. The study of sexual reproduction of plants has traditionally relied on light microscopy in combination with
Anna Maria Waszkielewicz et al.
Acta poloniae pharmaceutica, 72(1), 89-99 (2015-04-09)
A series of new N-(2,5-dimethylphenoxy)- and N-(2,3,5-trimethylphenoxy)alkylaminoalkanols [I-XVII] was synthesized and evaluated for anticonvulsant activity. Pharmacological tests included maximal electroshock (MES) and subcutaneous pentetrazole seizure threshold (scMet) assays as well as neurotoxicity (TOX) evaluation in mice after intraperitoneal (i.p.) administration
Jalaleddinne Omar Bouhidel et al.
Biochimica et biophysica acta, 1852(2), 277-289 (2014-06-15)
Reperfusion injury of the heart is a severe complication of angioplasty treatment of acute myocardial ischemia, for which no therapeutics are currently available. The present study aimed to identify whether and how a novel protein, netrin-1, induces cardioprotection in vivo
Xiangnan Kong et al.
International journal of oncology, 46(5), 2047-2056 (2015-04-01)
Breast cancer is one of the most common malignant tumors in the world. Long-term maintenance treatment is important for breast cancer. However, effective maintenance treatment is lacking for triple-negative breast cancer (TNBC). Traditional Chinese medicine (TCM) has shown its potential
Wylly Ramsés García-Niño et al.
Biological trace element research, 167(1), 130-145 (2015-03-17)
Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin
Chenzhong Fei et al.
Regulatory toxicology and pharmacology : RTP, 71(3), 585-589 (2015-02-04)
Nitromezuril (NZL) is a novel triazine compound that exhibits remarkable anticoccidial activity. However, mutagenicity and genotoxicity of NZL have not been evaluated to date. This study evaluated the potential risks of NZL by testing for bacterial reverse mutation (Ames), mouse
Jessica Frankum et al.
Oncotarget, 6(13), 10746-10758 (2015-04-18)
Based on a series of basic, preclinical and clinical studies, the Poly (ADP-ribose) Polymerase 1 (PARP1) inhibitor, olaparib, has recently been approved for use in ovarian cancer patients with BRCA1 or BRCA2 mutations. By identifying novel predictive biomarkers of tumour
C Blázquez et al.
Cell death and differentiation, 22(10), 1618-1629 (2015-02-24)
The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the CB1 receptor is highly expressed in the basal ganglia, mostly on terminals
Tamás Lőrincz et al.
Pathology oncology research : POR, 21(4), 1115-1121 (2015-05-13)
The recently described form of programmed cell death, ferroptosis can be induced by agents causing GSH depletion or the inhibition of GPX4. Ferroptosis clearly shows distinct morphologic, biochemical and genetic features from apoptosis, necrosis and autophagy. Since NAPQI the highly
Kayla A Martin et al.
Molecular and cellular biology, 35(23), 3934-3944 (2015-09-16)
Posttranslational modifications, such as poly(ADP-ribosyl)ation (PARylation), regulate chromatin-modifying enzymes, ultimately affecting gene expression. This study explores the role of poly(ADP-ribose) polymerase (PARP) on global gene expression in a lymphoblastoid B cell line. We found that inhibition of PARP catalytic activity
Pia D Bagamasbad et al.
Molecular endocrinology (Baltimore, Md.), 29(6), 856-872 (2015-04-14)
Cooperative, synergistic gene regulation by nuclear hormone receptors can increase sensitivity and amplify cellular responses to hormones. We investigated thyroid hormone (TH) and glucocorticoid (GC) synergy on the Krüppel-like factor 9 (Klf9) gene, which codes for a zinc finger transcription
Rym Ghaddab-Zroud et al.
PloS one, 9(9), e106983-e106983 (2014-09-18)
Reversing the escalating rate of obesity requires increased knowledge of the molecular mechanisms controlling energy balance. Liver X receptors (LXRs) and thyroid hormone receptors (TRs) are key physiological regulators of energetic metabolism. Analysing interactions between these receptors in the periphery
Lynda Uphouse et al.
Pharmacology, biochemistry, and behavior, 122, 16-19 (2014-03-22)
A brief restraint experience reduces lordosis behavior in ovariectomized females that have been hormonally primed with estradiol benzoate. The addition of progesterone to the priming prevents the lordosis inhibition. Based on prior studies with an inhibitor of progesterone metabolism, we
Cheryl A Tajon et al.
ACS nano, 8(9), 9199-9208 (2014-08-29)
Caspases are proteases involved in cell death, where caspase-3 is the chief executioner that produces an irreversible cutting event in downstream protein substrates and whose activity is desired in the management of cancer. To determine such activity in clinically relevant
Haiyan Wu et al.
PloS one, 10(2), e0115046-e0115046 (2015-02-07)
The rapid, sensitive and low-cost detection of macromolecular biomarkers is critical in clinical diagnostics, environmental monitoring, research, etc. Conventional assay methods usually require bulky, expensive and designated instruments and relative long assay time. For hospitals and laboratories that lack immediate
Julie Kim et al.
Talanta, 129, 106-112 (2014-08-17)
Using the role of p-iodophenol in enzyme assay, enhanced 1,1'-oxalyldiimidazole chemiluminescent enzyme immunoassays (ODI-CLEIAs) were developed to consecutively quantify trace levels of triple tumor markers, such as alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), and prostate specific antigen (PSA) in a
Hsiang-En Hsu et al.
The Journal of biological chemistry, 290(27), 16786-16796 (2015-05-08)
Snf1, a member of the AMP-activated protein kinase family, plays a critical role in metabolic energy control in yeast cells. Snf1 activity is activated by phosphorylation of Thr-210 on the activation loop of its catalytic subunit; following activation, Snf1 regulates
M Hashimoto et al.
Cell death & disease, 5, e1267-e1267 (2014-05-31)
Macrophages (MΦ) are functionally classified into two types, anti-inflammatory M2 and pro-inflammatory M1. Importantly, we recently revealed that soluble HIV-1 proteins, particularly the pathogenetic protein Nef, preferentially activate M2-MΦ and drive them towards an M1-like MΦ, which might explain the
Liang Kong et al.
Biological & pharmaceutical bulletin, 38(9), 1290-1301 (2015-09-04)
It is believed that neuronal death caused by abnormal deposition of amyloid-beta peptide is the major cause of the cognitive decline in Alzheimer's disease. Adult neurogenesis plays a key role in the rescue of impaired neurons and amelioration of cognitive
Ying-Hui Shan et al.
International journal of pharmaceutics, 479(2), 291-301 (2015-01-04)
Functional wound dressing has provided new challenges for researchers who focus on burn to improve skin graft quality, reduce scarring, and develop a pluristratified dermal or epidermal construct of a burn wound. This study aimed to investigate the effect of
Bin Fang et al.
Biochemical and biophysical research communications, 448(4), 443-447 (2014-05-07)
Cisplatin-induced ototoxicity affects a high percentage of new cancer patients worldwide. The detailed mechanism of cisplatin-induced ototoxicity is not completely understood. We investigated whether rapamycin could protect rats from cisplatin-induced ototoxicity. Forty-eight male Wistar rats were randomly divided into six
Fangrui Ding et al.
PloS one, 9(11), e112972-e112972 (2014-11-14)
Transient receptor potential cation channel 6 (TRPC6) is a nonselective cation channel, and abnormal expression and gain of function of TRPC6 are involved in the pathogenesis of hereditary and nonhereditary forms of renal disease. Although the molecular mechanisms underlying these
Ana Y Wang et al.
Biochemistry, 54(28), 4365-4373 (2015-07-02)
The secreted Streptococcus pyogenes cysteine protease SpeB is implicated in host immune system evasion and bacterial virulence. We present a small molecule inhibitor of SpeB 2477 identified from a high-throughput screen based on the hydrolysis of a fluorogenic peptide substrate
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