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Dimitri Vanhecke et al.
Beilstein journal of nanotechnology, 8, 2396-2409 (2017-12-14)
Little is known about the simultaneous uptake of different engineered nanoparticle types, as it can be expected in our daily life. In order to test such co-exposure effects, murine macrophages (J774A.1 cell line) were incubated with gold (AuNPs) and iron
Autophagy-lysosome pathway in renal tubular epithelial cells is disrupted by advanced glycation end products in diabetic nephropathy
Liu WJ, et al.
The Journal of Biological Chemistry, 290(33), 20499-20510 (2015)
Tamara Sternlieb et al.
PLoS neglected tropical diseases, 15(5), e0009435-e0009435 (2021-05-25)
Trypanosoma cruzi, the etiological agent of Chagas disease, has a digenetic life cycle. In its passage from the insect vector to the mammalian host, and vice versa, it must be prepared to cope with abrupt changes in environmental conditions, such
Jaegyu Hwang et al.
Journal of neuroimmunology, 226(1-2), 66-72 (2010-06-18)
We have previously shown that gangliosides induce autophagic cell death of brain astrocytes. As gangliosides are also known to induce inflammatory activation of astrocytes, we hypothesized that a canonical inflammatory signaling pathway NF-κB might be involved in the ganglioside-induced astrocyte
Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages
Kuhn DA, et al.
Beilstein Journal of Nanotechnology, 5(1), 1625-1636 (2014)
Wei Ye et al.
Connective tissue research, 54(1), 22-28 (2012-07-28)
Macroautophagy increases with age in rat intervertebral discs; however, the effect of macroautophagy on the process of intervertebral disc degeneration (IVDD) is still unclear. The aim of this study was to examine the presence of autophagosome, as well as the
Guido Wollmann et al.
Virology, 475, 1-14 (2014-12-03)
Vesicular stomatitis virus (VSV) shows promise as a vaccine-vector and oncolytic virus. However, reports of neurotoxicity of VSV remain a concern. We compared 12 antiviral compounds to control infection of VSV-CT9-M51 and VSV-rp30 using murine and human brain cultures, and
Cristina Corral-Ramos et al.
Autophagy, 11(1), 131-144 (2015-01-07)
In the fungal pathogen Fusarium oxysporum, vegetative hyphal fusion triggers nuclear mitotic division in the invading hypha followed by migration of a nucleus into the receptor hypha and degradation of the resident nucleus. Here we examined the role of autophagy
Heena Saini et al.
Cancer cell international, 21(1), 52-52 (2021-01-16)
Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients
Melissa S Hillwig et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(3), 1093-1098 (2011-01-05)
RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogenetic analyses suggest that they may carry out an important housekeeping role. However, the nature of this role has been elusive. Here we show that RNS2, an
A Rehman Khalid et al.
Genes, 10(9) (2019-08-31)
Fusarium oxysporum is the most important pathogen of potatoes which causes post-harvest destructive losses and deteriorates the market value of potato tubers worldwide. Here, F. oxysporum was used as a host pathogen model system and it was revealed that autophagy
Kyunghee Byun et al.
EMBO reports, 15(7), 801-808 (2014-05-16)
Hypothalamic leptin signaling plays a central role in maintaining body weight homeostasis. Here, we show that clusterin/ApoJ, recently identified as an anorexigenic neuropeptide, is an important regulator in the hypothalamic leptin signaling pathway. Coadministration of clusterin potentiates the anorexigenic effect
Junqiang Zhang et al.
Oncology reports, 26(1), 115-124 (2011-04-27)
Matrine has a wide range of pharmacological effects including antitumor activity in vitro and in vivo. Autophagy is closely associated with tumors and plays an important role in human tumor suppression, so inducing autophagy is a potential therapeutic strategy in
Shouliang Wang et al.
Drug design, development and therapy, 13, 1187-1196 (2019-05-23)
Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) exhibits strong neuron protective effects against neurotoxicity. Hence, we investigate the effect of TET on BUP-induced neurotoxicity
Zhichao Jin et al.
Journal of ethnopharmacology, 249, 112412-112412 (2019-11-22)
Xiaoshui decoction (XSD) is a traditional Chinese medicine compound prescription that has been shown to reinforce the spleen and remove the fluid retention, while being widely used in the treatment of malignant pleural effusion (MPE). We previously reported that XSD
Noboru Iwasaki et al.
Journal of cellular biochemistry, 116(7), 1300-1309 (2015-03-05)
Cells respond to ER-stress via ER-stress sensors, leading to the UPR and subsequent apoptosis; however, occasionally, they activate autophagy without subsequent apoptosis in response to ER-stress. We previously showed that the induction of apoptosis by ER-stress was related to the
Young Min Son et al.
International immunopharmacology, 10(5), 626-631 (2010-03-17)
In the present study, we examined the effects of ginsenoside Re (Re) on cytokine expression, cytokine-dependent autophagy and cell survival in human CD4(+) T cells. When CD4(+) T cells isolated from human peripheral blood were treated with Re, LC3 and
LiBo Jiang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(11), 1532-1542 (2014-08-05)
Although glucosamine has been suggested to be effective in the treatment of osteoarthritis, its effect on disc degeneration remains unclear. We sought to explore whether glucosamine can activate autophagy in rat nucleus pulposus (NP) cells and protect cells treated with
Paula Florian et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 90(3), 449-455 (2012-03-03)
Different cell types have been reported to internalize lactoferrin (Lf) by specific or nonspecific receptors. Our studies focused on the endocytic pathway of human Lf in macrophage-like THP-1 cells. Lactoferrin was found to be internalized by THP-1 cells differentiated with
Jinli Wang et al.
Scientific reports, 7(1), 982-982 (2017-04-22)
Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli. However, the effect of glucocorticoids on innate anti-mycobacterial defense, especially in macrophages remains largely unknown. Here, we found
Kenichi Shibuya et al.
Journal of experimental botany, 64(4), 1111-1120 (2013-01-26)
Autophagy is one of the main mechanisms of degradation and remobilization of macromolecules, and it appears to play an important role in petal senescence. However, little is known about the regulatory mechanisms of autophagy in petal senescence. Autophagic processes were
Sabine Pellett et al.
PloS one, 10(7), e0133737-e0133737 (2015-07-25)
Botulinum neurotoxins (BoNTs) are the causative agent of the severe and long-lasting disease botulism. At least seven different serotypes of BoNTs (denoted A-G) have been described. All BoNTs enter human or animal neuronal cells via receptor mediated endocytosis and cleave
Takahiko Akematsu et al.
Autophagy, 6(7), 901-911 (2010-08-28)
Programmed nuclear death (PND) in Tetrahymena is a unique process during conjugation, in which only the parental macronucleus is degraded and then eliminated from the progeny cytoplasm, but other co-existing nuclei such as new micro- and macronuclei are unaffected. PND
Raúl A Almeida et al.
Veterinary research communications, 35(2), 89-101 (2011-01-06)
Research on mastitis in dairy cows caused by Escherichia coli has reported the emergence of strains capable of inducing chronic mastitis and that these strains adhered to and internalized into bovine mammary epithelial cells better than strains of E. coli
Gábor Lendvai et al.
PloS one, 16(6), e0253065-e0253065 (2021-06-16)
The presence of autophagy has been indicated in cholangiocarcinoma (CC), which disease has poor prognosis and limited treatment options. Recently, CC has been classified by anatomical localization as intrahepatic (iCC), perihilar (pCC) and distal (dCC), showing different clinical and molecular
A Grimaldi et al.
Cancer biology & therapy, 16(4), 567-579 (2015-04-14)
Renal cell carcinoma is an aggressive disease often asymptomatic and weakly chemo-radiosensitive. Currently, new biologic drugs are used among which everolimus, an mTOR inhibitor, that has been approved for second-line therapy. Since mTOR is involved in the control of autophagy
Ji Young Kim et al.
Archives of oral biology, 57(8), 1018-1025 (2012-05-05)
Curcumin, a major active component of turmeric Curcuma longa, has been shown to have inhibitory effects on cancers. In vitro studies suggest that curcumin inhibits cancer cell growth by activating apoptosis, but the mechanism underlying the anticancer effects of curcumin
Erin E Congdon et al.
The Journal of biological chemistry, 288(49), 35452-35465 (2013-10-29)
Tau immunotherapy is effective in transgenic mice, but the mechanisms of Tau clearance are not well known. To this end, Tau antibody uptake was analyzed in brain slice cultures and primary neurons. Internalization was rapid (<1 h), saturable, and substantial
A Rehman Khalid et al.
Genes, 10(5) (2019-05-16)
Autophagy is a universal catabolic process preserved in eukaryotes from yeast to plants and mammals. The main purpose of autophagy is to degrade cytoplasmic materials within the lysosome/vacuole lumen and generate an internal nutrient pool that is recycled back to
Xi-Yuan Ge et al.
PloS one, 9(6), e101207-e101207 (2014-06-26)
Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone
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