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E-075
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A T Kicman et al.
Clinical endocrinology, 50(5), 661-668 (1999-09-01)
The ratio of urinary testosterone (T) to epitestosterone (EpiT) is used to detect T abuse in sport. Also, plasma or urinary concentrations of EpiT have been measured to assess testicular steroidogenesis during hormonal male contraception. Further investigations are required to
Michael E Baker
Steroids, 78(3), 337-340 (2013-01-15)
Estradiol (E2) is the principal physiological estrogen in mammals. E2 and its active metabolites, estrone and estriol have a characteristic phenolic A ring, unlike progesterone, testosterone, cortisol and aldosterone, which have an A ring containing a C3-ketone, a Δ(4) bond
Javier González-Sálamo et al.
Journal of separation science, 38(15), 2692-2699 (2015-05-28)
In this work, we have compared the selectivity of two commercial molecularly imprinted polymers (AFFINIMIP®SPE Estrogens and AFFINIMIP®SPE Zearalenone) for the extraction of 12 estrogenic compounds of interest (i.e. 17α-estradiol, 17β-estradiol, estrone, hexestrol, 17α-ethynylestradiol, diethylstibestrol, dienestrol, zearalenone, α-zearalanol, β-zearalanol, α-zearalenol
J R Pasqualini
Zentralblatt fur Gynakologie, 119 Suppl 2, 48-53 (1997-01-01)
Breast cancer tissue contains the enzymes necessary for local synthesis of estradiol (E2) and it was demonstrated that, despite the presence of the sulfatase and its messenger in hormone-dependent and hormone-independent breast cancer cells, this enzyme operates particularly in hormone-dependent
Sheikh O Jobe et al.
Hypertension (Dallas, Tex. : 1979), 61(2), 480-487 (2013-01-16)
Estrogens and estrogen metabolites have important functions in cardiovascular and other physiology, yet the patterns of estrogen synthesis, metabolism, and the individual plasma profile of estrogens and estrogen metabolites during human pregnancy as well as in preeclampsia remain undetermined. We
Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay.
L Viinikka et al.
Prostaglandins, 20(4), 759-766 (1980-10-01)
Xiaoxiao Liu et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 602-607 (2012-12-21)
Organic anion transporting polypeptides (OATP) have been extensively recognized as key determinants of absorption, distribution, metabolism, and excretion of various drugs because of their broad substrate specificity, wide tissue distribution, and the involvement of drug-drug interaction. As the first cloned
A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces.
Todd M Kolb et al.
Chest, 144(6), 1964-1968 (2013-12-04)
Gabriele Wehner et al.
The Journal of clinical endocrinology and metabolism, 99(4), 1393-1399 (2014-01-18)
The present study investigated the metabolism of estrone sulfate into bioactive estrogens in the human hair root, including the effects of hair growth phase, anatomical site, gender, and age. Healthy male (n = 18) and female (n = 20) subjects
Sebastian Buchinger et al.
Environmental toxicology and chemistry, 32(3), 526-534 (2013-01-03)
Sediments along the river Saale, one of the main tributaries of the river Elbe, were characterized with the yeast estrogen screen to elucidate possible sources of endocrine-disrupting compounds that might contribute to the downstream contamination of the river Elbe. At
Peter A Bain et al.
Environmental toxicology and chemistry, 33(10), 2297-2307 (2014-07-01)
Changes in the endocrine potency of municipal wastewater at 3 wastewater treatment plants (WWTPs) in Australia were investigated using a panel of in vitro receptor-driven transactivation assays. The assays were based on human estrogen receptor α, androgen receptor, progesterone receptor
Gianluca Scuderi et al.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 47(6), 489-492 (2012-12-12)
To evaluate the correlation between tear osmolarity and blood levels of 17-β estradiol, estrone, and testosterone in postmenopausal women with dry eye syndrome, and to assess the efficacy and safety of oral supplementation with phytoestrogens, lipoic acid, and eicosapentaenoic acid
K Farker et al.
Prostaglandins, 54(3), 655-664 (1997-11-28)
The purpose of the present work was to study the prostaglandin excretion in young nonpregnant ovulatory women during the menstrual cycle on the one hand and in postmenopausal women on the other hand and to investigate the influence of female
[Estrogen: estrone (E1), estradiol (E2) and estriol (E3)].
Y Shimizu et al.
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 2, 553-565 (1995-03-01)
Hangzhen Lan et al.
Journal of chromatography. A, 1365, 35-44 (2014-09-15)
A high-performance magnetic molecularly imprinted polymer (MIP) coating using zeolite imidazolate framework-8 coated magnetic iron oxide (Fe3O4@ZIF-8) as a carrier was developed for simultaneous automated solid phase microextraction of four estrogens in 24 food samples. The coating material, abbreviated as
Samuel D Quaynor et al.
The New England journal of medicine, 369(2), 164-171 (2013-07-12)
Although androgen resistance has been characterized in men with a normal chromosome complement and mutations in the androgen-receptor gene, a mutation in the gene encoding estrogen receptor α (ESR1) was previously described only in one man and not, to our
Jolanta Kumirska et al.
The Science of the total environment, 508, 498-505 (2014-12-19)
Pharmaceuticals are continually being released into the environment. Because of their physical and chemical properties, many of them or their bioactive metabolites can accumulate in sediments, sludge and soils, and induce adverse effects in terrestrial organisms. However, due to the
Kiyoshi Ito
The Tohoku journal of experimental medicine, 212(1), 1-12 (2007-04-28)
Hormone replacement therapy (HRT) has become available over the past few decades, but the risk of breast cancer with HRT remains controversial. The Women's Health Initiative Study has recently demonstrated that women receiving estrogen plus progestin (HRT) have an increased
[Estrogen: estrone (E1), estradiol (E2), estriol (E3) and estetrol (E4)].
Yukiko Shimizu
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 8, 425-438 (2005-09-10)
Shiori Sano et al.
Biochemical and biophysical research communications, 430(2), 810-815 (2012-12-04)
When DNA is damaged by alkylating agents, apoptosis is induced to exclude cells carrying DNA lesions in order to prevent mutations and cancer. MAPO1, identified as a component involved in the induction of apoptosis, interacts with AMP-activated protein kinase (AMPK)
H Kuhl et al.
Climacteric : the journal of the International Menopause Society, 10(4), 344-353 (2007-07-27)
Previous studies in postmenopausal women have demonstrated that, after oral administration of norethisterone, a small proportion of the compound is rapidly converted into ethinylestradiol. The shape of the concentration - time curve suggested that this occurred in the liver. The
William H Parker et al.
Clinical obstetrics and gynecology, 50(2), 354-361 (2007-05-22)
Approximately 78% of women between the ages of 45 and 64 years have prophylactic oophorectomy when hysterectomy is performed for benign disease to prevent the development of ovarian cancer. However, after menopause, the ovary continues to produce androstenedione and testosterone
Szabolcs Szarka et al.
Analytical and bioanalytical chemistry, 405(10), 3399-3406 (2013-02-02)
We show here that baseline separation of dansylated estrone, 17β-estradiol, and 17α-estradiol can be done, contrary to previous reports, within a short run time on a single RP-LC analytical column packed with particles bonded with phenyl-hexyl stationary phase. The chromatographic
Catherine L Carpenter et al.
Nutrition journal, 11, 102-102 (2012-12-12)
Accumulation of excess body fat increases breast cancer risk after menopause. Whether the localized breast is differently influenced by adipose tissue compared to the rest of the body, has not been well studied. Our purpose was to demonstrate feasibility and
Timothy J Kennedy et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(7), 753-759 (2013-03-01)
Endocrine disrupting compounds (EDCs) are a contaminant of emerging concern throughout the world, including developing countries where centralized water and wastewater treatment plants are not common. In developing countries, household scale water treatment technologies such as the biosand filter (BSF)
Joerg Betschinger et al.
Cell, 153(2), 335-347 (2013-04-16)
Factors that sustain self-renewal of mouse embryonic stem cells (ESCs) are well described. In contrast, the machinery regulating exit from pluripotency is ill defined. In a large-scale small interfering RNA (siRNA) screen, we found that knockdown of the tumor suppressors
Yoshihisa Shitara et al.
Journal of pharmaceutical sciences, 102(9), 3427-3435 (2013-02-27)
Previously, we reported a long-lasting inhibition of transport mediated by organic anion-transporting polypeptides (OATPs) in humans and rats by cyclosporin A (CsA). In the present study, we examined the effects of several other compounds on OATP1B1-mediated transport, with a focus
[Estrogen: estrone (E1), estradiol (E2), estriol (E3) and estetrol (4)].
Y Shimizu et al.
Nihon rinsho. Japanese journal of clinical medicine, 57 Suppl, 252-265 (2000-04-25)
B Zumoff et al.
Arteriosclerosis (Dallas, Tex.), 2(1), 58-67 (1982-01-01)
Plasma concentrations and urinary excretions of various hormones and hormone metabolites were measured in four groups. Group 1 was composed of 13 men with prior myocardial infarction; Group 2 contained 35 clinically normal men; Group 3 consisted of 44 men
Andreia Teixeira-Castro et al.
Brain : a journal of neurology, 138(Pt 11), 3221-3237 (2015-09-17)
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin
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