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Raimunda Sâmia Nogueira Brilhante et al.
Journal of medical microbiology, 64(Pt 4), 394-399 (2015-02-07)
It is believed that most microbial infections are caused by pathogens organized in biofilms. Recently, it was shown that the dimorphic fungus Histoplasma capsulatum, estimated to be the most common cause of fungal respiratory diseases, is also able to form
Adam G Staines et al.
The Biochemical journal, 384(Pt 3), 637-645 (2004-08-24)
Farnesol is an isoprenoid found in many aromatic plants and is also produced in humans, where it acts on numerous nuclear receptors and has received considerable attention due to its apparent anticancer properties. Although farnesol has been studied for over
K Hanley et al.
The Journal of biological chemistry, 275(15), 11484-11491 (2001-02-07)
The isoprenoids farnesol and juvenile hormone III (JH), metabolites of the cholesterol biosynthetic pathway, have been shown to stimulate fetal epidermal development in rodents. In this study we determined whether this effect might be attributed to a direct induction of
Milena Cotoras et al.
Mycologia, 105(1), 28-33 (2012-09-11)
This study demonstrates that the isoprenoid farnesol produces a toxic effect on the phytopathogenic fungus Botrytis cinerea in solid and liquid media. In solid media farnesol retarded 72 h the beginning of mycelial growth. Also, it was demonstrated that the
Efrat Mashiach-Farkash et al.
Oncotarget, 3(6), 629-639 (2012-07-11)
Neurofibromin regulates cell motility via three distinct GTPase pathways acting through two different domains, the Ras GTPase-activating protein-related domain (GRD) and the pre-GRD domain. First, the GRD domain inhibits Ras-dependent changes in cell motility through the mitogen activated protein cascade.
Mohit Tyagi et al.
Carbohydrate research, 413, 85-92 (2015-06-27)
Various carbohydrate-anchored triazole-linked lipids prepared by solvent-free mechanochemical azide-alkyne click reaction, on analysis by TEM, have been found to spontaneously self-assemble in solvents leading to structures of interesting physicochemical attributes. Interestingly, analogous compounds based on different sugars (e.g., d-glucose, and
Taísa Magnani Dinamarco et al.
Biochemical Society transactions, 39(5), 1544-1548 (2011-09-23)
FOH (farnesol), a non-sterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, has been shown to inhibit proliferation and induce apoptosis. We have been using Aspergillus nidulans and FOH as a model system and cell death stimulus, respectively, aiming to understand
Y Saisho et al.
Analytical biochemistry, 252(1), 89-95 (1997-11-05)
A nonradioisotopic method has been developed for the determination of all-trans-farnesyl pyrophosphate (FPP), the common intermediate at the branch point of the biosynthesis of cholesterol and nonsterol end products, in dog and human plasma. FPP was cleaved to the parent
B M Forman et al.
Cell, 81(5), 687-693 (1995-06-02)
Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that
EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium.
Takamitsu Matsuzawa et al.
The Journal of investigative dermatology, 134(4), 1158-1161 (2014-01-05)
Benjamin Horev et al.
ACS nano, 9(3), 2390-2404 (2015-02-11)
Development of effective therapies to control oral biofilms is challenging, as topically introduced agents must avoid rapid clearance from biofilm-tooth interfaces while targeting biofilm microenvironments. Additionally, exopolysaccharides-matrix and acidification of biofilm microenvironments are associated with cariogenic (caries-producing) biofilm virulence. Thus
N Charette et al.
Cell death & disease, 4, e471-e471 (2013-01-26)
Ras activation is a frequent event in human hepatocarcinoma that may contribute to resistance towards apoptosis. Salirasib is a ras and mTOR inhibitor that induces a pro-apoptotic phenotype in human hepatocarcinoma cell lines. In this work, we evaluate whether salirasib
Tamaki Cho et al.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 49(4), 281-286 (2008-11-13)
Farnesol is one of the quorum sensing molecules of Candida albicans. In this report, we discuss the effects of farnesol on: 1. growth of Candida albicans in vitro and in vivo; 2. the incorporation of biomolecules into the cell wall
Daniel Laheru et al.
Investigational new drugs, 30(6), 2391-2399 (2012-05-02)
S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all isoforms of Ras, including mutant Ras, from the plasma membrane. This study evaluated the activity, safety, and toxicity of salirasib in preclinical models and patients with metastatic pancreatic adenocarcinoma
Aspasia Katragkou et al.
The Journal of antimicrobial chemotherapy, 70(2), 470-478 (2014-10-08)
Biofilm formation by Candida albicans poses an important therapeutic challenge in human diseases. Typically, conventional antifungal agents encounter difficulty in treating and fully eradicating biofilm-related infections. Novel therapeutic approaches are needed to treat recalcitrant Candida biofilms. Farnesol is a quorum-sensing
Melanie L Langford et al.
Future microbiology, 4(10), 1353-1362 (2009-12-10)
Farnesol is a quorum-sensing molecule produced by Candida albicans that has many effects, including filament inhibition of this polymorphic fungus. In the past 9 years, the effect of farnesol on C. albicans has been reported in nearly 160 publications, with
Gisselle Moraima Chávez-Andrade et al.
Archives of oral biology, 107, 104481-104481 (2019-07-25)
This study aimed to evaluate the antimicrobial and biofilm anti-adhesion activities of poly(vinyl alcohol)-coated silver nanoparticles (AgNPs-PVA) and farnesol against Enterococcus faecalis, Candida albicans or Pseudomonas aeruginosa. Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) of the solutions, as
Roman Shchepin et al.
Bioorganic & medicinal chemistry, 16(4), 1842-1848 (2007-11-27)
A series of synthetic molecules combining a geranyl backbone with a heterocyclic or oxime head group are quorum-sensing molecules that block the yeast to mycelium transition in the dimorphic fungus Candida albicans. A number of the analogs have an IC50
Joung Hyuck Joo et al.
Cancer letters, 287(2), 123-135 (2009-06-13)
The isoprenoid alcohol farnesol is an effective inducer of cell cycle arrest and apoptosis in a variety of carcinoma cell types. In addition, farnesol has been reported to inhibit tumorigenesis in several animal models suggesting that it functions as a
Flávio Rodrigues Ferreira Alves et al.
Brazilian oral research, 27(1), 20-25 (2013-01-12)
This study evaluated the in vitro effects of four natural substances on the biomass of bacterial biofilms to assess their potential use as root canal irrigants. The following substances and their combinations were tested: 0.2% farnesol; 5% xylitol; 20% xylitol;
Ayman Sabra et al.
Infection and immunity, 82(1), 413-422 (2013-11-06)
Candida lusitaniae is an emerging opportunistic yeast and an attractive model to discover new virulence factors in Candida species by reverse genetics. Our goal was to create a dpp3Δ knockout mutant and to characterize the effects of this gene inactivation
Raimunda Sâmia Nogueira Brilhante et al.
Medical mycology, 53(2), 93-98 (2014-12-30)
Sporotrichosis is a subacute or chronic subcutaneous infection, caused by the fungus Sporothrix schenkii complex, occurring in human and animal tissues. Potassium iodide and itraconazole have been used as effective therapy for first-choice treatment, while amphotericin B may be indicated
Rossana A Cordeiro et al.
Medical mycology, 51(1), 53-59 (2012-06-21)
The objective of this study was to evaluate the antifungal activity of farnesol and its interaction with traditional antifungals against drug-resistant strains of Candida species. To do so, we studied the minimum in vitro inhibitory concentration (MIC) of amphotericin B
Najla Nasr et al.
Blood, 120(4), 778-788 (2012-06-09)
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendritic cells and CD4 T cells, without inducing any interferons. Inhibition of type I interferon induction
Yixiong Chen et al.
Scientific reports, 5, 10625-10625 (2015-05-30)
Bax inhibitor 1 (BI-1) is a highly conserved protein originally identified as a suppressor of the proapoptotic protein Bax to inhibit cell death in animals and plants. The orthologs of BI-1 are widely distributed in filamentous fungi but their functions
Effect of Trans, Trans-Farnesol on Pseudogymnoascus destructans and Several Closely Related Species.
Daniel B Raudabaugh et al.
Mycopathologia, 180(5-6), 325-332 (2015-07-15)
Bat white-nose syndrome, caused by the psychrophilic fungus Pseudogymnoascus destructans, has dramatically reduced the populations of many hibernating North American bat species. The search for effective biological control agents targeting P. destructans is of great importance. We report that the
Man-Shun Fu et al.
PloS one, 7(8), e42894-e42894 (2012-08-11)
Hsp12p is considered to be a small heat shock protein and conserved among fungal species. To investigate the expression of this heat shock protein in the fungal pathogen Candida albicans we developed an anti-CaHsp12p antibody. We show that this protein
Jiaxi Ding et al.
BMC developmental biology, 8, 120-120 (2009-01-02)
Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors. We demonstrate a novel role for cholesterol during germ
S Zafar et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(9), 711-721 (2014-04-26)
The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to play a role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). This study determined the effect of the bisphosphonate, zoledronic acid and the replenishment
Nuno Cerca et al.
BMC research notes, 5, 244-244 (2012-05-18)
Staphylococcus epidermidis is the major bacterial species found in biofilm-related infections on indwelling medical devices. Microbial biofilms are communities of bacteria adhered to a surface and surrounded by an extracellular polymeric matrix. Biofilms have been associated with increased antibiotic tolerance
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