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Reaction design and optimization

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facet applications:Reaction design and optimization
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放大指南:光催化反应
光催化反应放大指南,通过高通量筛选试剂盒最大限度提高放大成功率。
均苯并四咪唑(HBTM):一种用于不对称酰基化的通用有机催化剂
作为我们不对称催化产品组合的一部分,我们很自豪地以(R)和(S)对映体形式提供异硫脲有机催化剂均苯并四咪唑(HBTM)。
溶剂稳定剂系统
描述溶剂的稳定剂系统,包括酯、乙酯、四氢呋喃、氯化溶剂、氯仿和二氯甲烷。
用于不对称合成的手性胺
手性胺已广泛用于不对称合成,例如用作对映选择性去质子化反应中的手性碱,或用于拆分消旋的酸。
TEMPO催化氧化
TEMPO(2,2,6,6-四甲基哌啶氧基或2,2,6,6-四甲基哌啶1-氧基)及其衍生物在有机氧化反应催化剂中可以作为稳定的硝酰基使用。TEMPO由Lebedev和Kazarnovskii于1960年发现,其具有的稳定自由基性质得益于其庞大的取代基团阻碍了自由基与其他分子之间发生反应。
BINOL及其衍生物
我们展示了一篇有关BINOL及其衍生物的文章。
PYBOX配体 - 大结合位点和刚性支架
PYBOX配体由吡啶环侧接两个恶唑啉基团组成,由Nishiyama在1989年合成成功。
氟烷基化:Togni试剂的扩展
目前的氟烷基化工具包括Togni试剂、高价碘全氟烷基化试剂、氟烷基溴化物、硅烷类和羧酸盐类以及用于后期氟烷基化的磺酰氟类。
过氧化物形成溶剂
对在正常储存条件下可发生自动氧化形成不稳定且有潜在危险的过氧化物副产物的实验室溶剂进行说明。
四(二甲基氨基)乙烯(TDAE)
在2001年,佛罗里达大学的William Dolbier,Jr.教授报告了一种亲核三氟甲基化的方法,该方法基于在强力双电子还原剂四(二甲基氨基)乙烯(TDAE)存在下使用CF3I生成三氟甲基阴离子。
TPGS-750-M:用于室温下水中有机金属化学反应的第二代两亲物
Lipshutz及其同事最近开发了第二代技术,用于基于聚氧乙戊基-α-生育酚琥珀酸酯衍生物TPGS-750-M的原始PTS表面活性剂。
Baeyer-Villiger氧化反应
Baeyer-Villiger氧化是与羰基相邻的碳-碳键的氧化裂解,其可将酮转化为酯、环酮转化为内酯。
羟醛缩合反应
羟醛缩合反应是由Charles Wurtz推出的有机反应,他于1872年首次从乙醛中制备了β-羟基醛。
Phosgene and Phosgene Substitutes
Phosgene is 170 times more reactive than TP, the main phosgene substitute. Therefore, reactions with phosgene can be carried out under much milder conditions than with TP. Compounds will react faster and at lower temperatures (often at -78°C), preserving sensitive
Red-Al® Reducing Agent
Red-Al®, or sodium bis(2-methoxyethoxy)aluminum dihydride (Vitride®, SMEAH), is a versatile reducing agent and a good substitute for LiAlH4 in many reactions. Red-Al® is nonpyrophoric, although still moisture-sensitive, and is available in solution, allowing for easier handling compared to LiAlH4.
Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)
This technical article discusses Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®).
Task-Specific Ionic Liquids
Task-Specific Ionic Liquids (TSILs) for the selective liquid/liquid extraction of heavy metals from aqueous systems were first published by Robin D. Rogers et al. in the year 2001.
BASIONICS™, BASF’s Portfolio of Ionic Liquids
Under the trade name BASIONICS™, BASF offers a portfolio of Ionic Liquids—mainly based on imidazolium cations. The BASIONICS™ portfolio opens up a broad range of basic properties of Ionic Liquids and is classified into standard, acidic, basic, liquid at RT
Chiral Vicinal Diamines for Asymmetric Synthesis
Chiral vicinal diamines are of tremendous interest to the synthetic chemist as they are found in many chiral catalysts and pharmaceuticals.
Selective 1,2-Additions with LaCl3·2LiCl
While the 1,2-addition of Grignard reagents to ketones is undoubtedly a powerful transformation, oftentimes selectivity issues arising from competitive alpha-deprotonation detract from the use of these reagents.
Asymmetric Transfer Hydrogenation
The use of transfer hydrogenation to reduce alkenes, carboxyl groups, ketones, or imines has become very popular.
Oxidizing and Reducing Agents
Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis
Mild Mg – Halogen Exchange
Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.
Heterocyclic Aryne Precursors:
New Opportunities for the Synthesis of
Highly Substituted Indoles and Pyridines
New and efficient methods for the synthesis of functionalized heterocycles are highly sought after.
Alkali Metal Silica Gels from SiGNa
SiGNa Chemistry has recently developed a technology for encapsulating alkali metals into nano-structured porous oxides to create stable, free flowing powders with varying reactivities (based on the intended application).
Applications for Bis(pyridine)iodonium Tetrafluoroborate
Bis(pyridine)iodonium tetrafluoroborate is a mild iodinating and oxidizing reagent capable of selectively reacting with a wide range of unsaturated substrates and tolerates a variety of functional groups.
CBILS©
The use of CBILS© – Carbonate Based Ionic Liquid Synthesis – developed by the Austrian company proionic, offers one of the simplest, yet most elegant synthetic methods for the production of ionic liquids
Trialkylphosphine for Morita-Baylis Hillman Reactions
The use of amines and phosphines in nucleophilic catalysis is well precedented; however, arguably one of the severe limitations with respect to exploiting the more nucleophilic, yet less basic, phosphine in this regard is its air sensitivity.
Drying Agents
Many products such as aluminas, silicas and molecular sieves can be employed as reasonably effective drying agents which can usually be conveniently regenerated. Current chemical literature reflects an active interest in the drying process, and even the method by which
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