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H-085
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Carla Bizzarri et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(11-12), 1059-1064 (2013-01-19)
Precocious pubarche (PP) is defined as the onset of pubic hair at 8 years of age in girls and at 9 years of age in boys. PP is idiopathic (IPP) in most children, but it is the earliest manifestation of
Hong Yu et al.
Zhonghua fu chan ke za zhi, 47(9), 651-654 (2012-11-13)
To investigate the clinical features and pregnant outcomes of the pregnant women with congenital adrenal hyperplasia (CAH) 21-hydroxylase deficiency (21-OHD). The clinical features, therapies, pregnant outcomes of the pregnant women with 21-OHD were retrospectively reviewed in Peking Union Medical College
Michael J Gibney et al.
The American journal of clinical nutrition, 82(3), 497-503 (2005-09-13)
Metabolomics has been widely adopted in pharmacology and toxicology but is relatively new in human nutrition. The ultimate goal, to understand the effects of exogenous compounds on human metabolic regulation, is similar in all 3 fields. However, the application of
Beverly E Hird et al.
Archives of disease in childhood, 99(2), 158-164 (2013-11-15)
Congenital adrenal hyperplasia (CAH) is not currently included in the UK newborn screening programme. We investigated the hypothesis that, owing to non-specificity of symptoms, a proportion of males affected by salt-wasting (SW) CAH have died in infancy without being diagnosed.
M Katagiri et al.
Archives of biochemistry and biophysics, 317(2), 343-347 (1995-03-10)
Human cytochrome b5 has a profound effect on the 17,20-lyase activities catalyzed by purified, human cytochrome P450c17. It enhances the conversion of 17 alpha-hydroxypregnenolone to dehydroepiandrosterone by 13-fold and the conversion of 17 alpha-hydroxyprogesterone to androstenedione by at least 10-fold.
H F Escobar-Morreale et al.
Fertility and sterility, 72(4), 629-638 (1999-10-16)
To determine the role of heterozygosity for mutations in the 21-hydroxylase gene (CYP21) in the pathogenesis of hyperandrogenism. Controlled clinical study. Tertiary care institutional hospital. Forty hirsute women and 13 healthy control women. The source of androgen excess was determined
Roel J Bolt et al.
Pediatric research, 52(3), 405-410 (2002-08-24)
To study the maturity of the adrenal cortex in preterms born before 33 wk of gestation, basal levels of cortisol and cortisone and the cortisol and 17-hydroxyprogesterone (17-OHP) response to 1 microg/kg adrenocorticotropic hormone stimulation were measured in 24 appropriate-for-gestational
Best practice recommendations for compounding 17-hydroxyprogesterone.
Joe Cabaleiro
International journal of pharmaceutical compounding, 16(1), 86-87 (2012-10-12)
Areana Diogo Nascimento et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(3), 246-249 (2012-12-01)
To evaluate the relationship between serum anti-Mullerian hormone levels (AMH) and insulin resistance (IR) before and after meformin treatment and to compare AMH levels of polycystic ovary syndrome (PCOS) women in the early follicular phase. Twenty PCOS women with IR
R van der Pas et al.
The Journal of endocrinology, 215(3), 403-412 (2012-10-06)
The antifungal agent ketoconazole is often used to suppress cortisol production in patients with Cushing's syndrome (CS). However, ketoconazole has serious side effects and is hepatotoxic. Here, the in vitro effects of ketoconazole and fluconazole, which might be less toxic
O Laitinen et al.
Clinical rheumatology, 2(4), 401-406 (1983-12-01)
No significant differences were found in plasma concentrations and urinary excretion of prostaglandin E2 (PGE2), 6-keto-prostaglandin-F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TxB2), between rheumatoid arthritis patients and controls. However, urinary excretion of PGEe and 6-keto-PGF1 alpha tended to be
Tulsidas G Shrivastav et al.
Journal of immunoassay & immunochemistry, 34(1), 94-108 (2013-01-18)
In steroid enzyme immunoassay (EIA), there is an increase or decrease of labeled steroid recognition by antibody due to homologous and heterologous combinations of enzyme conjugate with immunogen that affects sensitivity of the assay. We have introduced three to 18
T L Perry et al.
Clinica chimica acta; international journal of clinical chemistry, 117(1), 7-12 (1981-11-25)
Cystinylglycine, recently identified as a normal small peptide in human plasma, has diagnostic importance for several genetically determined disorders. We found cystinylglycine absent from the plasma of a patient with pyroglutamic acidemia, and the peptide was either absent or greatly
Stefan Németh et al.
Clinica chimica acta; international journal of clinical chemistry, 414, 211-214 (2012-09-19)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder most commonly caused by defects in the CYP21A2 gene. Neonatal CAH-screening based on 17-hydroxyprogesterone (17-OHP) measurements prevents life-threatening salt wasting conditions in newborns, but results in a considerable false-positive rate. Therefore
Han-bi Wang et al.
Zhonghua fu chan ke za zhi, 47(7), 518-521 (2012-11-13)
To investigate efficient diagnosis and treatment of 17α-hydroxylase (17OHD) deficiency by summarizing clinical characteristics of those patients. From January 1983 to January 2010, 48 cases with 17OHD in Peking Union Medical College Hospital were studied retrospectively. Among 48 patients with
Cedric Shackleton et al.
Steroids, 68(9), 707-717 (2003-11-20)
This paper collates and reviews a number of clinical cases published over the last 20 years that we believe describe a novel steroid disorder associated with genital ambiguity. The authors of the original papers were unable to diagnose their patients
K Deveci et al.
European review for medical and pharmacological sciences, 17(2), 261-265 (2013-02-05)
Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by short lived, febrile serosae inflammatory attacks. FMF has various effects in multiple systems and organs. In the present study, our aim was to evaluate adrenal steroidogenesis in female FMF
R Hampl et al.
Experimental and clinical endocrinology, 100(3), 117-119 (1992-01-01)
In order to assess the contribution of individual steroidogenic organs to over-all steroid biosynthesis, the basal plasma levels of six hormonal steroids, reflecting the function of gonads and adrenals, as well as both gonadotropins and prolactin, have been determined in
M Y Roth et al.
The Journal of clinical endocrinology and metabolism, 98(3), 1198-1206 (2013-01-26)
The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed with LH suppression. Methods to lower IT-T further are needed to determine the relationship between IT-T and
H Peck et al.
Clinica chimica acta; international journal of clinical chemistry, 94(3), 237-240 (1979-06-15)
The urine of untreated phenylketonurics in the first weeks of life contains gamma-glutamylphenylalanine (0.07--0.69 mmol/g creatinine, 12 samples) visible on the normal 2-dimensional electrophoreto-chromatogram. This compound is less prominent or absent when urine from older untreated phenylketonurics is examined and
Shilpi Singh et al.
Diabetes & metabolic syndrome, 6(4), 207-211 (2012-12-04)
An interaction between adiponectin, steroid synthesis or action and measures of insulin resistance (IR) have been reported in the pathogenesis of polycystic ovary syndrome (PCOS). The present study was done to determine plasma adiponectin concentration (PAC) in women with and
Vania Tonetto-Fernandes et al.
The Journal of clinical endocrinology and metabolism, 91(6), 2179-2184 (2006-03-23)
21-Hydroxylase deficiency (21OHD) is the most common cause of congenital adrenal hyperplasia, followed in frequency by 11beta-hydroxylase deficiency (11betaOHD). Although the relative frequency of 11betaOHD is reported as between 3 and 5% of the cases, these numbers may have been
Asan Onder et al.
Journal of pediatric endocrinology & metabolism : JPEM, 25(7-8), 681-685 (2012-11-20)
There are few reports of an association between Turner syndrome (TS) and 21-hydroxylase deficiency. However, this association is more frequent in some populations. The aim of this study was to evaluate the incidence of 21-hydroxylase deficiency in patients with TS
Joanna M Oswiecimska et al.
Neuro endocrinology letters, 33(8), 787-791 (2013-02-09)
Excessive hyperandrogenism, though proper hydrocortisone supplementation is a frequent clinical problem in girls with congenital adrenal hyperplasia (CAH). This may result from autonomic regulation of androgen production established in prenatal life. It has been suggested that the length of the
Loren Kline et al.
General and comparative endocrinology, 185, 37-43 (2013-02-13)
Estrogen (E) has been shown to have an inhibitory effect on the contractility of gastrointestinal smooth muscle, including the gallbladder. During pregnancy E and progesterone (P) levels are elevated. A biliary stasis may develop during pregnancy that is characterized by
A method for the measurement of plasma hydroxyeicosatetraenoic acid levels.
C Chavis et al.
Analytical biochemistry, 271(1), 105-108 (1999-06-11)
En-Pei Chiang et al.
Arthritis research & therapy, 7(6), R1254-R1262 (2005-11-10)
Previously we observed strong and consistent associations between vitamin B6 status and several indicators of inflammation in patients with rheumatoid arthritis. Clinical indicators, including the disability score, the length of morning stiffness, and the degree of pain, and biochemical markers
Cerebrospinal fluid estrone in pseudotumor cerebri: a change in cerebral steroid hormone metabolism?
V Toscano et al.
Journal of endocrinological investigation, 14(2), 81-86 (1991-02-01)
Estrogen and androgen hormones were studied in the plasma and cerebrospinal fluid (CSF) of five patients affected by pseudotumor cerebri (PTC). Six men and six women without cerebral or endocrine diseases were selected as controls. Androstenedione (A), testosterone (T), 17-hydroxyprogesterone
Trine Jensen et al.
The Journal of rheumatology, 31(9), 1698-1708 (2004-09-01)
To assess the applicability of serum concentrations of markers of synovial inflammation, cartilage, and bone metabolism in relation to conventional markers of disease activity, bone mineral density (BMD) of the hand, and radiographic outcome. Biochemical markers of collagen tissue metabolism
Adriana Pabón et al.
Molecules (Basel, Switzerland), 18(3), 3356-3378 (2013-03-16)
Solanum nudum Dunal steroids have been reported as being antimalarial compounds; however, their concentration in plants is low, meaning that the species could be threatened by over-harvesting for this purpose. Swern oxidation was used for hemisynthesis of diosgenone (one of
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