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Ming-fai Fong et al.
Nature communications, 6, 6339-6339 (2015-03-10)
Homeostatic plasticity encompasses a set of mechanisms that are thought to stabilize firing rates in neural circuits. The most widely studied form of homeostatic plasticity is upward synaptic scaling (upscaling), characterized by a multiplicative increase in the strength of excitatory
Faith L Anderson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 183(2), 378-392 (2021-07-22)
Exposure to environmental toxicants can increase the risk of developing age-related neurodegenerative disorders. Exposure to the widely used organophosphate pesticide chlorpyrifos (CPF) is associated with increased risk of developing Alzheimer's disease and Parkinson's disease, but the cellular mechanisms underlying CPF
Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients.
Dhillon, et al.
Journal of the Royal Society, Interface / the Royal Society, 19, 20220576-20220576 (2022)
Hong-Yan Lin et al.
Biochemical pharmacology, 96(2), 93-106 (2015-05-11)
The high incidence of cancer and the side effects of traditional anticancer drugs motivate the search for new and more effective anticancer drugs. In this study, we synthesized 17 kinds of aryl dihydrothiazol acyl shikonin ester derivatives and evaluated their
John M Lattier et al.
Oncogene, 39(50), 7253-7264 (2020-10-12)
Glioblastoma (GBM), or grade IV astrocytoma, is a malignant brain cancer that contains subpopulations of proliferative and invasive cells that coordinately drive primary tumor growth, progression, and recurrence after therapy. Here, we have analyzed functions for megalencephalic leukoencephalopathy with subcortical
Thomas Gonatopoulos-Pournatzis et al.
Molecular cell, 77(6), 1176-1192 (2020-01-31)
Microexons represent the most highly conserved class of alternative splicing, yet their functions are poorly understood. Here, we focus on closely related neuronal microexons overlapping prion-like domains in the translation initiation factors, eIF4G1 and eIF4G3, the splicing of which is
Chengxiao Ma et al.
Cell death & disease, 12(7), 674-674 (2021-07-07)
Parkinson's disease is a common neurodegenerative disease. Cell transplantation is a promising therapeutic option for improving the survival and function of dopaminergic neurons, but the mechanisms underlying the interaction between the transplanted cells and the recipient neurons remain to be
Fabrice Gonnot et al.
Nature communications, 14(1), 3346-3346 (2023-06-09)
Despite advances in cardioprotection, new therapeutic strategies capable of preventing ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2) phosphorylation at serine 663 is a clinical and pathophysiological event of cardiac function. Indeed
Luke Grundy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(17), 3900-3916 (2021-03-18)
Understanding the sensory mechanisms innervating the bladder is paramount to developing efficacious treatments for chronic bladder hypersensitivity conditions. The contribution of Mas-gene-related G protein-coupled receptors (Mrgpr) to bladder signaling is currently unknown. Using male and female mice, we show with
Valeria Kizner et al.
Methods in molecular biology (Clifton, N.J.), 1994, 219-226 (2019-05-28)
FLIPR-based calcium assay enables the detection and characterization of neuronal excitability by using electrical field stimulation to evoke and record action potential-driven calcium transients in induced pluripotent stem cell (iPSC)-derived cortical forebrain neurons. Here we describe high throughput measurement of
Markley Silva Oliveira-Junior et al.
International immunopharmacology, 70, 302-312 (2019-03-11)
In the central nervous system (CNS), neuroinflammation, especially that modulated by the cell response of astrocytes and microglia, is associated with damage to neurons in neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and, Multiple Sclerosis. Lupeol is a dietary
Zita Hubler et al.
Cell chemical biology, 28(6), 866-875 (2021-02-27)
Small molecules that promote the formation of new myelinating oligodendrocytes from oligodendrocyte progenitor cells (OPCs) are potential therapeutics for demyelinating diseases. We recently established inhibition of specific cholesterol biosynthesis enzymes and resulting accumulation of 8,9-unsaturated sterols as a unifying mechanism
Amanda C Daulagala et al.
Methods in molecular biology (Clifton, N.J.), 2367, 235-247 (2020-08-14)
With the realization that mechanical forces mediate many biological processes and contribute to disease progression, researchers are focusing on developing new methods to understand the role of mechanotransduction in biological systems. Despite recent advances in stretching devices that analyze the
Wenjun Zhang et al.
Frontiers in cellular neuroscience, 17, 1195470-1195470 (2023-06-26)
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in the NOTCH3 gene. Patients with CADASIL experience recurrent strokes, developing into cognitive defect and vascular dementia. CADASIL is
Caio Vaz Rimoli et al.
Nature communications, 13(1), 301-301 (2022-01-15)
Single-molecule localization microscopy provides insights into the nanometer-scale spatial organization of proteins in cells, however it does not provide information on their conformation and orientation, which are key functional signatures. Detecting single molecules' orientation in addition to their localization in
Myungjun Ko et al.
PNAS nexus, 1(1), pgac013-pgac013 (2022-04-08)
A small population of self-renewing stem cells initiate tumors and maintain therapeutic resistance in glioblastoma (GBM). Given the limited treatment options and dismal prognosis for this disease, there is urgent need to identify drivers of stem cells that could be
Hisayuki Yao et al.
Nature, 560(7716), 55-60 (2018-07-20)
Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid tumours, metastases of ALL seldom involve the parenchyma but are isolated to the leptomeninges, which is an
Chumin Sun et al.
Physical review. E, 105(4-1), 044406-044406 (2022-05-21)
In the study of biological networks, one of the major challenges is to understand the relationships between network structure and dynamics. In this paper, we model in vitro cortical neuronal cultures as stochastic dynamical systems and apply a method that
Ben L Callif et al.
Molecular and cellular neurosciences, 80, 170-179 (2017-01-23)
Axon growth is coordinated by multiple interacting proteins that remain incompletely characterized. High content screening (HCS), in which manipulation of candidate genes is combined with rapid image analysis of phenotypic effects, has emerged as a powerful technique to identify key
Sara M Zarate et al.
Journal of neurochemistry, 157(3), 710-726 (2020-12-24)
Apoptotic endoplasmic reticulum (ER) stress is a major mechanism for dopaminergic (DA) loss in Parkinson's disease (PD). We assessed if low doses of the partial α4β2 nicotinic acetylcholine receptor agonist, cytisine attenuates apoptotic ER stress and exerts neuroprotection in substantia
Arzuhan Koc et al.
Methods in molecular biology (Clifton, N.J.), 2520, 161-170 (2021-12-01)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational cardiac research. Obtaining hiPSC-CM culture as a single-cell, monolayer or three-dimensional clusters for downstream applications can be challenging. Thus, it is critical to develop
Re-Evaluating the Relevance of the Oxygen-Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition.
D'aes, et al.
International Journal of Molecular Sciences, 24 (2023)
Shihong Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(22), 5817-5826 (2008-05-30)
GPR56 is a member of the family of adhesion G-protein-coupled receptors that have a large extracellular region containing a GPS (G-protein proteolytic site) domain. Loss-of-function mutations in the GPR56 gene cause a specific human brain malformation called bilateral frontoparietal polymicrogyria
Retrospective analysis of enhancer activity and transcriptome history.
Boers, et al.
Nature Biotechnology (2023)
Vidhant Pal et al.
Scientific reports, 12(1), 6110-6110 (2022-04-14)
We previously showed that pancreatic beta-cells plated on laminin matrix express reduced levels of FGFR1, a receptor linked to beta-cell metabolism and differentiation. Due to recent evidence that adult beta-cells also express FGFR5, a co-receptor for FGFR1, we now aim
Christopher J Sampson et al.
Methods in molecular biology (Clifton, N.J.), 827, 359-367 (2011-12-07)
The cellular branch of the Drosophila larval innate immune system consists of three immunosurveillance (haemocyte) cell types: plasmatocytes, crystal cells, and lamellocytes. In order to examine haemocyte cytoskeletal dynamics or migration, most researchers use embryos or in vitro cell culture
Qingling Xia et al.
Journal of biophotonics, 12(7), e201800403-e201800403 (2019-03-13)
The aim of the present study is to optimize parameters for inhibiting neuronal activity safely and investigating thermal inhibition of rat cortex neural networks in vitro by continuous infrared (IR) laser. Rat cortex neurons were cultured on multi-electrode arrays until
Graysen Vigneux et al.
Bioengineering (Basel, Switzerland), 9(1) (2022-01-21)
The lens of the eye is one of the most radiosensitive tissues. Although the exact mechanism of radiation-induced cataract development remains unknown, altered proliferation, migration, and adhesion have been proposed as factors. Lens epithelial cells were exposed to X-rays (0.1-2
Ana Marin Navarro et al.
Cell death & disease, 11(1), 52-52 (2020-01-25)
In this study, we take advantage of human induced pluripotent stem (iPS) cell-derived neural stem cells and brain organoids to study the role of p53 during human brain development. We knocked down (KD) p53 in human neuroepithelial stem (NES) cells
Huiya Yang et al.
JCI insight, 8(9) (2023-04-05)
GM3 synthase deficiency (GM3SD) is an infantile-onset epileptic encephalopathy syndrome caused by biallelic loss-of-function mutations in ST3GAL5. Loss of ST3GAL5 activity in humans results in systemic ganglioside deficiency and severe neurological impairment. No disease-modifying treatment is currently available. Certain recombinant
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