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Zhao-Shan Liu et al.
Nature immunology, 20(1), 18-28 (2018-12-05)
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. G3BP1 enhanced DNA binding of cGAS
Yumeng Cao et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 70(1), 89-98 (2020-11-14)
The dysfunction of pulmonary microvascular endothelial cells (PMVECs) is one of the critical characteristics of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) induced by severe infection. PIM1 is a constitutively active serine/threonine kinase that is involved in multiple biological processes.
Bo Liu et al.
International immunopharmacology, 88, 107020-107020 (2020-11-14)
Alveolar hypercoagulation and pulmonary inflammation are important characteristics and they regulate each other in acute respiratory distress syndrome (ARDS). NF-κB pathway has been confirmed to be involved in regulation of this crosstalk. Emodin, a traditional Chinese herb, shows potent inhibitory
Josué Hernández-Pasos et al.
Journal of experimental zoology. Part B, Molecular and developmental evolution, 328(3), 259-274 (2017-02-24)
Melanotransferrin (MTf) is a protein associated with oncogenetic, developmental, and immune processes which function remains unclear. The MTf gene has been reported in numerous vertebrate and invertebrate species, including echinoderms. We now report the finding of four different MTfs in
Dan Zhang et al.
Journal of cellular physiology, 233(1), 688-698 (2017-03-23)
Understanding the role and underlying regulation mechanism of autophagy in lipopolysaccharide-induced lung injury (LPS-LI) may provide potentially new pharmacological targets for treatment of acute lung injury. The aim of this study was to investigate the functional significance of autophagy in
Peitao Zhou et al.
Frontiers in cell and developmental biology, 8, 56-56 (2020-03-03)
Macrophage-orchestrated chronic inflammation plays an important role in cardiovascular disease, including accelerating the development of calcific aortic valve disease (CAVD). M1 and M2 macrophage polarization imbalances can alter intensity of inflammatory responses. Recombinant human interleukin 37 (IL-37) could be involved
Bryan Leaw et al.
Stem cell research & therapy, 8(1), 46-46 (2017-03-01)
Human amnion epithelial cells (hAECs) are clonogenic and have been proposed to reduce inflammatory-induced tissue injury. Perturbation of the immune response is implicated in the pathogenesis of perinatal brain injury; modulating this response could thus be a novel therapy for
Laura L Bronsart et al.
PloS one, 11(1), e0146601-e0146601 (2016-01-12)
Superoxide anion is produced during normal cellular respiration and plays key roles in cellular physiology with its dysregulation being associated with a variety of diseases. Superoxide anion is a short-lived molecule and, therefore, its homeostatic regulation and role in biology
Tu M Tran et al.
Investigative ophthalmology & visual science, 61(8), 16-16 (2020-07-15)
To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD). The qAF imaging was performed on eyes of
Feng Guo et al.
Asian Pacific journal of tropical medicine, 8(12), 1049-1054 (2015-12-27)
To study effect of SecinH3 on lung injury induced by the sepsis of rats. A total of 30 SPF Wistar rats were randomly divided into two groups, including 5 rats in the control group and 25 in the model group.
Pandi He et al.
Journal of agricultural and food chemistry, 66(39), 10205-10214 (2018-09-14)
Eriodictyol, a natural flavonoid mainly distributed in citrus fruits and peanut, has been well-documented with possession of excellent anti-inflammatory, antioxidant, and anticancer bioactivities. This work focus on the protective effects of eriodictyol on LPS-induced neuroinflammation, amyloidogenesis, cognitive impairment, and the
Kohichiro Tsukida et al.
BMC immunology, 17(1), 21-21 (2016-06-28)
Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer's patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-like receptor (TLR)-4 activation. In view of the important role played by phagocytosis in the
Eman Khatib-Massalha et al.
Nature communications, 11(1), 3547-3547 (2020-07-17)
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neutrophil mobilization in acute inflammation is
Xingang Zuo et al.
Research (Washington, D.C.), 2020, 8970480-8970480 (2020-03-12)
Cell migration plays a pivotal role in many pathological and physiological processes. So far, most of the studies have been focused on 2-dimensional cell adhesion and migration. Herein, the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization
Yuan Zhang et al.
Medical science monitor : international medical journal of experimental and clinical research, 20, 1452-1460 (2014-08-21)
The anti-oxidative and anti-inflammatory activities of electro-acupuncture (EA), a traditional clinical method, are widely accepted, but its mechanisms are not yet well defined. In this study, we investigated the role of extracellular signal-regulated kinases1/2 (ERK1/2) pathways on electro-acupuncture - mediated
Christopher D Scharer et al.
Nature communications, 11(1), 3989-3989 (2020-08-12)
Upon stimulation, B cells assume heterogeneous cell fates, with only a fraction differentiating into antibody-secreting cells (ASC). Here we investigate B cell fate programming and heterogeneity during ASC differentiation using T cell-independent models. We find that maximal ASC induction requires
Kayo Sato et al.
The Journal of biological chemistry, 287(30), 25163-25172 (2012-06-05)
We have previously shown that a single nucleotide polymorphism rs11536889 in the 3'-untranslated region (UTR) of TLR4 was associated with periodontitis. In this study the effects of this single nucleotide polymorphism on Toll-like receptor (TLR) 4 expression were investigated. Monocytes
H Huang et al.
Cellular and molecular biology (Noisy-le-Grand, France), 63(8), 58-63 (2017-09-09)
The study wasintended to examinethe protective effect of cinnamaldehyde (CM) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice model.The results of the investigation confirmed that, LPS induced inflammatory cytokines such as TNF-α, IL-6, IL-13 and IL-1β were significantly decreased by
Shigeki Suzuki et al.
Scientific reports, 9(1), 3825-3825 (2019-03-09)
It is well known that dental pulp tissue can evoke some of the most severe acute inflammation observed in the human body. We found that dental pulp cells secrete a factor that induces tumor necrosis factor-α production from macrophages, and
Akihiro Kimura et al.
The Journal of experimental medicine, 215(8), 2197-2209 (2018-06-24)
NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. In this study, we found a novel role of NQO1 in suppressing Toll-like receptor (TLR)-mediated innate immune responses. NQO1-deficient macrophages selectively produced excessive amounts of IL-6, IL-12, and
Cristian Piras et al.
Molecular bioSystems, 13(2), 392-405 (2017-01-11)
E. coli is one of the most frequently involved bacteria in uterine diseases. Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria involved in pathogenic processes leading to post-partum metritis and endometritis in cattle. It also causes
Katherine Labbé et al.
Immunity, 35(6), 897-907 (2011-12-27)
Pathogen and danger recognition by the inflammasome activates inflammatory caspases that mediate inflammation and cell death. The cellular inhibitor of apoptosis proteins (cIAPs) function in apoptosis and innate immunity, but their role in modulating the inflammasome and the inflammatory caspases
Luan Luan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 628-636 (2018-04-22)
Osteoarthritis is the most common bone-joint disease in middle and older people all over the world. Tanshinone IIA (Tan IIA) is the main lipophilic diterpenoid isolated from the root of Salvia miltiorrhiza Bunge (Lamiaceae). This study analyzed the protective effects
Yingying Zhang et al.
Frontiers in physiology, 11, 590027-590027 (2020-11-17)
Acute kidney injury (AKI) is one of the most common complications affecting hospitalized patients associated with an extremely high mortality rate. However, the underlying pathogenesis of AKI remains unclear that largely limits its effective management in clinic. Increasing evidence demonstrated
Blake Bertani et al.
EcoSal Plus, 8(1) (2018-08-02)
The cell envelope is the first line of defense between a bacterium and the world-at-large. Often, the initial steps that determine the outcome of chemical warfare, bacteriophage infections, and battles with other bacteria or the immune system greatly depend on
Rongrong Huang et al.
Autophagy, 13(10), 1722-1741 (2017-08-09)
Circular RNAs are a subclass of noncoding RNAs in mammalian cells; however, whether these RNAs are involved in the regulation of astrocyte activation is largely unknown. Here, we have shown that the circular RNA HIPK2 (circHIPK2) functions as an endogenous
Jibran A Wali et al.
PloS one, 9(11), e113128-e113128 (2014-11-19)
Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce endoplasmic reticulum (ER) and oxidative stress-mediated apoptosis of islet cells in vitro. ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3
Katherine Sattler et al.
Scientific reports, 11(1), 14689-14689 (2021-07-21)
The non-selective cation channel transient receptor potential vanilloid 1 (TRPV1) is expressed throughout the cardiovascular system. Recent evidence shows a role for TRPV1 in inflammatory processes. The role of TRPV1 for myocardial inflammation has not been established yet. Human induced
Mikail E Abbasov et al.
Nature chemistry, 13(11), 1081-1092 (2021-09-11)
Recent advances in chemical proteomics have begun to characterize the reactivity and ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic electrophiles have been evaluated for interactions with the lysine proteome. Here, we report an
Huayuan Tang et al.
Journal of immunology (Baltimore, Md. : 1950), 199(2), 570-580 (2017-06-16)
Intracellular calcium (Ca
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