跳转至内容
Merck
CN
搜索范围

L8662

应用筛选条件
关键词:'L8662'
显示 1-30 #N/A 1352 条结果 关于 "L8662" 范围 论文
Nicola Ciliberti et al.
Phytopathology, 105(3), 325-333 (2014-10-30)
The effect of temperature and wetness duration on infection of Vitis vinifera inflorescences (from "inflorescence clearly visible" to "end of flowering" stages) and young berry clusters (at "fruit swelling" and "berries groat-sized" stages) by Botrytis cinerea was investigated. Artificial inoculations
Daniela Michlmayr et al.
Journal of virology, 88(17), 9553-9567 (2014-06-06)
The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains unclear which
Ganapathi Raj Murugesan et al.
Journal of the science of food and agriculture, 95(12), 2521-2527 (2014-11-05)
Efficacy of a multi-strain direct-fed microbial product (PoultryStar(®) ME; PS) and a xylanase enzyme product on the dietary energy utilization efficiency and resulting performance in broiler chickens was evaluated. Apart from performance parameters, cecal and serum metabolites and activities of
João H D Blanco et al.
Autonomic neuroscience : basic & clinical, 193, 97-103 (2015-10-17)
Hypertension is often accompanied by autonomic dysfunction, which is detrimental to cardiac regulation. On the other hand, cholinergic stimulation through inhibition of acetylcholinesterase appears to have beneficial effects on cardiac autonomic control. Thus, our objective was to investigate the effects
Elpida Tsika et al.
Neurobiology of disease, 77, 49-61 (2015-03-04)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 contains functional GTPase and kinase domains. The most common G2019S mutation enhances the kinase activity of LRRK2 in vitro whereas G2019S LRRK2 expression
Jingming Li et al.
Journal of diabetes research, 2015, 963289-963289 (2015-04-14)
NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidase in retinal endothelial cells. Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes. In the current study, we investigated
Masoumeh Emamghoreishi et al.
Iranian journal of basic medical sciences, 18(3), 240-246 (2015-05-07)
The neuroprotective effect of lithium has been attributed to its therapeutic action. However, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. Thus, the aim of
Tanja Hüsch et al.
World journal of urology, 33(12), 1921-1928 (2015-04-24)
To describe the evolution of the current technique in percutaneous nephrolithotomy (PCNL) with a special focus on access tract closure techniques. A systematic review of outcomes and complications of tubeless PCNL was conducted using the MEDLINE and Pubmed databases between
Denise K Gessner et al.
Archives of animal nutrition, 69(5), 399-410 (2015-08-26)
In rodents, forced activation of hepatic peroxisome proliferator-activated receptor α (PPARα) by administration of exogenous PPARα activators during lactation leads to a reduction of milk triacylglycerol (TAG) production. Herein, we investigated whether a negative energy balance (NEB) induced by feed
Jie Li et al.
Nature chemical biology, 10(12), 1003-1005 (2014-11-05)
Small molecules that specifically activate an intracellular protein of interest are highly desirable. A generally applicable strategy, however, remains elusive. Herein we describe a small molecule-triggered bioorthogonal protein decaging technique that relies on the inverse electron-demand Diels-Alder reaction for eliminating
Jitender Mehla et al.
Journal of bacteriology, 197(15), 2508-2516 (2015-05-20)
Mycobacteriophages are viruses that infect mycobacterial hosts and are prevalent in the environment. Nearly 700 mycobacteriophage genomes have been completely sequenced, revealing considerable diversity and genetic novelty. Here, we have determined the protein complement of mycobacteriophage Giles by mass spectrometry
Song P Seto et al.
Bioconjugate chemistry, 26(2), 286-293 (2015-01-27)
Bone morphogenetic protein-2 (BMP-2) plays an important role in bone and cartilage formation and is of interest in regenerative medicine. Heparin can interact electrostatically with BMP-2 and thus has been explored for controlled release and potential stabilization of this growth
Kristina Brazhnik et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(5), 1065-1075 (2015-03-26)
An immunodiagnostic lab-on-a-bead suspension microarray based on microbeads encoded with quantum dots (QDs) has been developed and preclinically validated for multiplexed quantitative detection of prostate cancer markers in human serum samples. The sensitivity and specificity of the microarray are similar
Eun-Jae Lee et al.
Nature communications, 6, 7168-7168 (2015-05-20)
Genetic aspects of autism spectrum disorders (ASDs) have recently been extensively explored, but environmental influences that affect ASDs have received considerably less attention. Zinc (Zn) is a nutritional factor implicated in ASDs, but evidence for a strong association and linking
C F García-Prieto et al.
Vascular pharmacology, 65-66, 3-12 (2014-12-23)
Genetic obesity models exhibit endothelial dysfunction associated to adenosine monophosphate-activated protein kinase (AMPK) dysregulation. This study aims to assess if mild short-term caloric restriction (CR) restores endothelial AMPK activity leading to an improvement in endothelial function. Twelve-week old Zucker lean
R M Meyer et al.
Molecular psychiatry, 19(12), 1284-1294 (2013-10-16)
Hormones in the hypothalamus-pituitary-adrenal (HPA) axis mediate many of the bodily responses to stressors, yet there is no clear relationship between the levels of these hormones and stress-associated mental illnesses such as posttraumatic stress disorder (PTSD). Therefore, other hormones are
Cecilia V Vranych et al.
Biochimica et biophysica acta, 1843(9), 1805-1817 (2014-04-23)
SUMOylation, a posttranslational modification of proteins, has been recently described as vital in eukaryotic cells. In a previous work, we analyzed the role of SUMO protein and the genes encoding the putative enzymes of the SUMOylation pathway in the parasite
Zhaoxia Qian et al.
ACS nano, 9(2), 1263-1270 (2015-01-27)
We report a synthetic approach to produce raspberry-like plasmonic nanostructures with unusually strong magnetic resonances, termed raspberry-like metamolecules (raspberry-MMs). The synthesis based on the surfactant-assisted templated seed-growth method allows for the simultaneous one-step synthesis and assembly of well-insulated gold nanoparticles.
Wenying Fan et al.
Journal of chromatography. A, 1418, 36-44 (2015-10-05)
Graphene oxide (GO) is an ideal adsorbent for polar and less polar compounds due to its hexagonal carbon network structure with oxygen-containing groups, while its strong hydrophilicity and water solubility limited its application in sample pretreatment techniques. Herein, GO was
L M Procopciuc et al.
Chirurgia (Bucharest, Romania : 1990), 108(5), 711-718 (2013-10-26)
DNA repair processes involved the removal of modified bases through the base excision repair (BER) pathway and removal of damaged nucleotides through the nucleotide excision repair (NER) pathways. in order to determine the association between XPD(Lys751Gln) and XRCC1 (Arg399Gln) SNPs
JongDae Shin et al.
Nature, 511(7507), 86-89 (2014-05-30)
In female mice, two forms of X-chromosome inactivation (XCI) ensure the selective silencing of female sex chromosomes during mouse embryogenesis. Beginning at the four-cell stage, imprinted XCI (iXCI) exclusively silences the paternal X chromosome. Later, around implantation, epiblast cells of
Christine Wittig et al.
PloS one, 10(7), e0131946-e0131946 (2015-07-15)
Geraniol exerts several direct pharmacological effects on tumor cells and, thus, has been suggested as a promising anti-cancer compound. Because vascularization is a major precondition for tumor growth, we analyzed in this study the anti-angiogenic action of geraniol. In vitro
Ali Jebali et al.
Colloids and surfaces. B, Biointerfaces, 126, 297-302 (2015-01-21)
The main aim of this study was to evaluate the uptake of E6 mRNA antisense into cervical cancer cells, induced by human papilloma virus (HPV). In this study, the carrier of the antisense was tri-calcium phosphate nanoparticles (TCP NPs) conjugated
Nicolas Guérin et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 103, 179-184 (2015-06-27)
A rapid method was developed to efficiently measure (210)Po in urine samples in an emergency situation. Polonium-210 in small urine samples (10 mL) was spontaneously deposited on a stainless steel disc in 1 M HCl at room temperature for 4
Sajjad Khan et al.
AAPS PharmSciTech, 16(4), 800-810 (2015-01-07)
This study aimed to develop films for potential delivery of omeprazole (OME) via the buccal mucosa of paediatric patients. Films were prepared using hydroxypropylmethylcellulose (HPMC), methylcellulose (MC), sodium alginate (SA), carrageenan (CA) and metolose (MET) with polyethylene glycol (PEG 400)
Dhweeja Dasarathy et al.
Journal of chromatography. A, 1418, 77-82 (2015-10-03)
A new spiral tube assembly was designed to improve the column capacity and partition efficiency for protein separation. This spiral tube assembly has greater column capacity than the original tubing because of an increase in radial grooves from 4 to
Daniele Passeri et al.
Nanoscale, 7(34), 14358-14367 (2015-08-08)
Based on atomic force microscopy (AFM), torsional harmonics atomic force microscopy (TH-AFM, also referred to with the commercial name HarmoniX™) allows one to perform a quantitative characterization of the mechanical properties of soft samples on the nanometer scale. In this
Josune Orbe et al.
Journal of medicinal chemistry, 58(5), 2465-2488 (2015-02-17)
Growing evidence suggests that matrix metalloproteinases (MMP) are involved in thrombus dissolution; then, considering that new therapeutic strategies are required for controlling hemorrhage, we hypothesized that MMP inhibition may reduce bleeding by delaying fibrinolysis. Thus, we designed and synthesized a
Grazielle V B Huguenin et al.
Nutrition journal, 14, 54-54 (2015-05-30)
To investigate the effect of partially defatted Granulated Brazil nut (GBN) on biomarkers of oxidative stress and antioxidant status of hypertensive and dyslipidemic patients on nutrition and drug approaches. Ninety one hypertensive and dyslipidemic subjects of both genders (51.6 %
Yan Xu et al.
Journal of virology, 89(7), 3846-3858 (2015-01-23)
Hepatitis C virus (HCV) entry involves binding to cell surface heparan sulfate (HS) structures. However, due to the lipoprotein-like structure of HCV, the exact contribution of virion components to this interaction remains controversial. Here, we investigated the relative contribution of
1/46