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M3761
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Zuojia Chen et al.
Immunity, 54(1), 151-163 (2020-11-22)
The gastrointestinal tract is known as the largest endocrine organ that encounters and integrates various immune stimulations and neuronal responses due to constant environmental challenges. Enterochromaffin (EC) cells, which function as chemosensors on the gut epithelium, are known to translate
Metronidazole-induced encephalopathy: case report and review of MRI findings.
Jamsheed A Desai et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 38(3), 512-513 (2011-04-26)
Fabrizio Sgolastra et al.
Journal of periodontology, 83(10), 1257-1269 (2012-01-10)
The combination of Amoxicillin and metronidazole (AMX/MET) as an adjunctive treatment to scaling root planing (SRP) has been proposed for the treatment of chronic periodontitis; however, its effectiveness and clinical safety remain to be defined. The purpose of the present
Emiliano Di Cicco et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 44(2), 435-440 (2013-06-29)
A severe outbreak of scuticociliatosis occurred in Australian pot-bellied seahorse, Hippocampus abdominalis (Lesson, 1872), kept at the Vancouver Aquarium Marine Science Centre (Vancouver, British Columbia, Canada). Clinical signs included anorexia, lethargy, irregular respiration, and death. Cytology and histopathology revealed a
Neelam Pushker et al.
American journal of ophthalmology, 156(1), 178-183 (2013-04-30)
To evaluate the role of oral corticosteroids as an anti-inflammatory adjunct in the treatment of orbital cellulitis. Prospective, comparative, single-masked, interventional clinical study. setting: Tertiary eye care center (All India Institute of Medical Sciences). study population: Patients with acute onset
Mireia Uribe-Herranz et al.
The Journal of clinical investigation, 130(1), 466-479 (2019-12-10)
Alterations in gut microbiota impact the pathophysiology of several diseases, including cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts potent immune modulatory effects, inducing tumor-associated antigen (TAA) cross-priming with antitumor CD8+ T cell elicitation and abscopal effects.
I S Sönmez et al.
The Journal of clinical pediatric dentistry, 37(3), 231-234 (2013-07-17)
These 3 case reports the outcome of revascularization treatment in necrotic immature molars. During treatment, a tri antibiotic mix was used to disinfect the pulp for 2 weeks. Then a blood clot was created in the canal, over which mineral
Elenaz Naderkhani et al.
Journal of pharmaceutical sciences, 103(6), 1882-1890 (2014-03-26)
Permeability is a crucial property of orally administered drugs. Therefore, in drug discovery, it is important to employ methods suitable for rapidly and reliably screening the permeability of large numbers of new drug candidates. The phospholipid vesicle-based permeation assay (PVPA)
Jon M Davison et al.
Developmental biology, 304(2), 811-824 (2007-03-06)
Prior studies with transgenic zebrafish confirmed the functionality of the transcription factor Gal4 to drive expression of other genes under the regulation of upstream activator sequences (UAS). However, widespread application of this powerful binary system has been limited, in part
Thomas C Wehler et al.
Journal of cancer research and clinical oncology, 139(10), 1667-1672 (2013-08-07)
Treatment with cetuximab is accompanied by the development of an acneiform follicular skin exanthema in more than 80 % of patients. Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or
Kimberly Johnson et al.
Glia, 64(7), 1170-1189 (2016-04-22)
Radial glial cells are presumptive neural stem cells (NSCs) in the developing nervous system. The direct requirement of radial glia for the generation of a diverse array of neuronal and glial subtypes, however, has not been tested. We employed two
Kornchanok Wayakanon et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4455-4465 (2013-08-08)
The gram-negative anaerobe Porphyromonas gingivalis colonizes the gingival crevice and is etiologically associated with periodontal disease that can lead to alveolar bone damage and resorption, promoting tooth loss. Although susceptible to antibiotics, P. gingivalis can evade antibiotic killing by residing
Purnima Verma et al.
International journal of biological macromolecules, 73, 138-145 (2014-12-03)
The present study deals with improvement of the mucoadhesive properties of monoolein based cubic nanoparticles by incorporating chitosan. Chitosan-tailored cubic nanoparticles were prepared by thin film hydration followed by ultrasonication employing clotrimazole as model drug. The effect of Pluronic F127
Jan Stener Joergensen et al.
Expert opinion on pharmacotherapy, 15(15), 2173-2191 (2014-09-10)
Preterm birth is the major cause of perinatal mortality and morbidity in high-income countries. The etiology of preterm birth is multifactorial but there is overwhelming evidence to implicate infection as a major cause. Abnormal genital tract flora in early pregnancy
Holly M Pope et al.
PloS one, 9(7), e103283-e103283 (2014-07-25)
Axon degeneration is a feature of many peripheral neuropathies. Understanding the organismal response to this degeneration may aid in identifying new therapeutic targets for treatment. Using a transgenic zebrafish line expressing a bacterial nitroreductase (Ntr)/mCherry fusion protein in the peripheral
Abolfazl Zendedel et al.
JPMA. The Journal of the Pakistan Medical Association, 63(3), 336-339 (2013-08-07)
To evaluate Helicobacter pylori resistance to amoxicillin, clarithromycin, metronidazole and tetracycline in Mashhad, Iran. The cross-sectional study was done from January to May 2008 in Mashhad, involving 185 patients who had been indicated for endoscopy and lesions had been found.
Kaori Cho et al.
iScience, 24(10), 103117-103117 (2021-10-07)
The suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive cellular responses. In particular, SOCS3 is involved in the regulation of metabolic syndromes, such as obesity and diabetes, by suppressing leptin and insulin
Anna Gadaj et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 105-115 (2014-05-06)
An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their corresponding hydroxy metabolites (HMMNI, ipronidazile-OH and metronidazole-OH) in aquaculture tissue. Samples were extracted by shaking in acetonitrile
Robert Krautz et al.
eLife, 9 (2020-12-31)
Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms to prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via RasV12-overexpression in the postmitotic salivary glands (SGs) of Drosophila larvae, we overrode the
Shankumar Mooyottu et al.
International journal of food microbiology, 192, 111-116 (2014-12-03)
Clostridium difficile is a pathogen of significant public health concern causing a life-threatening, toxin-mediated enteric disease in humans. The incidence and severity of the disease associated with C. difficile have increased in the US with the emergence of hypervirulent strains
Michael Selgrad et al.
World journal of gastroenterology, 20(43), 16245-16251 (2014-12-05)
To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori (H. pylori) therapy-naive or pre-treated. H. pylori strains were isolated from antrum and corpus biopsies from 66 patients that
Kristine A Kuhn et al.
PloS one, 9(12), e114195-e114195 (2014-12-06)
IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to
Tran Huu Dung et al.
Journal of biomedical nanotechnology, 9(7), 1286-1292 (2013-08-06)
A series of dendrimer G5-pluronic F127 nanofilms (at 1:10, 1:20 and 1:30 mole ratios), loaded with various percent of metronidazole hydrochloride, were prepared by the drug deposition with/without gelatin coating. The nanostructural feature of dendrimer G5-pluronic F127 as a matrix
Faezeh Karami et al.
Iranian journal of parasitology, 14(4), 631-638 (2020-02-27)
Trichomoniasis is one of the most common nonviral sexually transmitted infections worldwide which drug-resistant cases of the infection are rising. The aim of the study was to assessment the in vitro activity of Foeniculum vulgare and its main essential oil
Amy J C Dohmen et al.
Oncotarget, 9(38), 25034-25047 (2018-06-05)
Treatment of advanced head and neck cancer is associated with low survival, high toxicity and a widely divergent individual response. The sponge-gel-supported histoculture model was previously developed to serve as a preclinical model for predicting individual treatment responses. We aimed
Huan-Lin Chen et al.
The American journal of tropical medicine and hygiene, 89(6), 1214-1218 (2013-10-30)
Amebic liver abscess (ALA) had previously been endemic in Taiwan, particularly in the southern region, although its occurrence in the southeastern area was unknown. Thus, we conducted a retrospective study for southeastern Taiwan. We identified 14 patients who were diagnosed
Marie-Pierre Otto et al.
Journal of travel medicine, 20(2), 131-133 (2013-03-08)
Amebiasis, the parasitic disease caused by Entamoeba histolytica, may result in extra-intestinal diseases among which liver abscess is the most common manifestation. We report two cases of amebic liver abscess illustrating the inequal sensitivity of serologic tests detecting anti-amebic antibodies.
Qian Li et al.
Microbes and infection, 16(1), 17-27 (2013-10-22)
Pseudomonas aeruginosa is an important opportunistic bacterial pathogen, causing infections of respiratory and other organ systems in immunocompromised hosts that may invade and proliferate in mucosal epithelial cells to induce apoptosis. Previous studies suggest that oral bacteria, especially gram-negative periodontal
Amanda L Prince et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 673-687 (2014-06-15)
T cell development in the thymus produces multiple lineages of cells, including innate T cells. Studies in mice harboring alterations in TCR signaling proteins or transcriptional regulators have revealed an expanded population of CD4(+) innate T cells in the thymus
Dina Zandbergen et al.
Journal of periodontology, 84(3), 332-351 (2012-05-23)
The treatment of periodontitis frequently begins with a non-surgical phase that includes scaling and root planing (SRP) and, on occasion, the use of systemic antibiotics. The goal of this review is to systematically evaluate the data concerning the effect of
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