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Takashi Watanabe et al.
The Journal of cell biology, 210(5), 737-751 (2015-09-02)
Microtubules (MTs) play critical roles in various cellular events, including cell migration. End-binding proteins (EBs) accumulate at the ends of growing MTs and regulate MT end dynamics by recruiting other plus end-tracking proteins (+TIPs). However, how EBs contribute to MT
Davi A G Mázala et al.
American journal of physiology. Cell physiology, 308(1), C33-C40 (2014-10-10)
Duchenne muscular dystrophy (DMD) is one of the most frequent types of muscular dystrophy. Alterations in intracellular calcium (Ca(2+)) handling are thought to contribute to the disease severity in DMD, possibly due to the activation of Ca(2+)-activated proteases. The purpose
Maria T Contestabile et al.
Molecular vision, 20, 325-333 (2014-03-29)
To describe the clinical and molecular findings of an Italian family with a new mutation in the choroideremia (CHM) gene. We performed a comprehensive ophthalmologic examination, fundus photography, macular optical coherence tomography, perimetry, electroretinography, and fluorescein angiography in an Italian
Matthew C Henn et al.
Journal of the American Heart Association, 4(8), e002016-e002016 (2015-08-26)
ATP-sensitive potassium (K(ATP)) channel openers provide cardioprotection in multiple models. Ion flux at an unidentified mitochondrial K(ATP) channel has been proposed as the mechanism. The renal outer medullary kidney potassium channel subunit, potassium inward rectifying (Kir)1.1, has been implicated as
Mariko Izumo et al.
eLife, 3 (2014-12-20)
In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The
Marie Besnier et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3351-3361 (2014-04-25)
The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among which is the vascular endothelial growth factor receptor type 2 (VEGFR2), a key component of angiogenesis. Because PTP1B deficiency in mice improves left ventricular (LV) function 2 mo after
Charlotte D'Mello et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10821-10830 (2015-08-01)
Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease, chronic liver disease) commonly develop debilitating symptoms (i.e., sickness behaviors) that arise from changes in brain function. The microbiota-gut-brain axis alters brain function and probiotic ingestion can influence behavior.
Arkaitz Carballo et al.
Viruses, 12(5) (2020-05-10)
Naturally occurring covert infections in lepidopteran populations can involve multiple viruses with potentially different transmission strategies. In this study, we characterized covert infection by two RNA viruses, Spodoptera exigua iflavirus 1 (SeIV-1) and Spodoptera exigua iflavirus 2 (SeIV-2) (family Iflaviridae)
Rangarajan Padmanabhan et al.
Journal of cell science, 128(9), 1773-1786 (2015-03-22)
The epithelial-to-mesenchymal transition (EMT) is important for the formation of migratory neural crest cells during development and is co-opted in human diseases such as cancer metastasis. Chick premigratory cranial neural crest cells lose intercellular contacts, mediated in part by Cadherin-6B
Seyed-Mostafa Pirseyedi et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 128(12), 2403-2414 (2015-08-05)
A compensating, recombined Lr59 translocation with greatly reduced alien chromatin was identified. Microsatellite locus Xdupw217 occurs within the remaining segment and can be used as a co-dominant marker for Lr59. In earlier studies, leaf rust (caused by Puccinia triticina Eriks.)
Beiyun Wang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(3), 1142-1150 (2015-06-27)
Diabetes and Alzheimer's disease are often associated with each other, whereas the relationship between two diseases is ill-defined. Although hyperglycemia during diabetes is a major cause of encephalopathy, diabetes may also cause chronic inflammatory complications including peripheral neuropathy. Hence the
Sanae Saka et al.
Journal of human genetics, 60(10), 573-580 (2015-07-24)
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis in many parts of the world. Although previous genome-wide association studies (GWAS) identified the major susceptibility loci for IgAN, the causal genes currently remain unknown. We performed a
Miranda M Gray et al.
Molecular ecology, 23(24), 6011-6028 (2014-11-06)
Big bluestem (Andropogon gerardii) is an ecologically dominant grass with wide distribution across the environmental gradient of U.S. Midwest grasslands. This system offers an ideal natural laboratory to study population divergence and adaptation in spatially varying climates. Objectives were to:
Naomi W Lucchi et al.
Malaria journal, 13, 462-462 (2014-11-28)
Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared
Salwa Zehdi-Azouzi et al.
Annals of botany, 116(1), 101-112 (2015-06-27)
Date palms (Phoenix dactylifera, Arecaceae) are of great economic and ecological value to the oasis agriculture of arid and semi-arid areas. However, despite the availability of a large date palm germplasm spreading from the Atlantic shores to Southern Asia, improvement
Loredana Amigoni et al.
Cell cycle (Georgetown, Tex.), 14(15), 2429-2438 (2015-06-06)
To investigate the specific target of PKA in the regulation of cell cycle progression and cell size we developed a new approach using the yeast strain GG104 bearing a deletion in adenylate cyclase gene and permeable to cAMP ( cyr1Δ
Sébastien Déon et al.
Water research, 47(7), 2260-2272 (2013-02-26)
One of the major difficulties for the prediction of separation performances in the case of multi-ionic mixtures nanofiltration lies in the description of the concentration polarization phenomenon. Usual models available in literature do not take account of the polarization phenomenon
Jacqueline Ramírez et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(7), 928-935 (2015-04-15)
OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the UDP-glucuronosyltransferases (UGTs) involved in OTS167 metabolism, study the relationship between UGT genetic polymorphisms and hepatic OTS167 glucuronidation, and investigate
Sang-Hun Lee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 10039-10057 (2015-07-15)
Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active CB1 receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to the synapse-specific calibration
Doory Kim et al.
PloS one, 10(4), e0124581-e0124581 (2015-04-16)
Correlative fluorescence light microscopy and electron microscopy allows the imaging of spatial distributions of specific biomolecules in the context of cellular ultrastructure. Recent development of super-resolution fluorescence microscopy allows the location of molecules to be determined with nanometer-scale spatial resolution.
Naoki Tamura et al.
Biology open, 3(11), 1108-1115 (2014-11-02)
Rab GTPases are master regulators of eukaryotic endomembrane systems, particularly functioning in membrane tethering to confer the directionality of intracellular membrane trafficking. However, how exactly Rab GTPases themselves act upon membrane tethering processes has remained enigmatic. Here, we thoroughly tested
Igor Arregi et al.
PloS one, 10(6), e0130610-e0130610 (2015-06-20)
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein, normally enriched in nucleoli, that performs several activities related to cell growth. NPM mutations are characteristic of a subtype of acute myeloid leukemia (AML), where mutant NPM seems to play an oncogenic role.
H Hosseinifar et al.
Andrology, 3(3), 526-531 (2015-04-14)
The absence of the acrosome causes the situation which is called globozoospermia. There are a few studies, mostly as case reports, about correlation between levels of sperm DNA damage in patients with total round-headed spermatozoa. We investigated this correlation as
Youn-Kyoung Goo et al.
Malaria journal, 14, 299-299 (2015-08-06)
Vivax malaria occurring in the Republic of Korea is occasionally characterized by a long latent infection induced by hypnozoites in the liver. So far, the mechanisms responsible for short and long latent infections of vivax malaria are not known. Therefore
Christian K Pfaller et al.
Journal of virology, 89(15), 7735-7747 (2015-05-15)
Defective interfering RNAs (DI-RNAs) of the viral genome can form during infections of negative-strand RNA viruses and outgrow full-length viral genomes, thereby modulating the severity and duration of infection. Here we document the frequent de novo generation of copy-back DI-RNAs
C L Ward et al.
Cell death & disease, 5, e1572-e1572 (2014-12-17)
Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional RNA/DNA-binding protein that is pathologically associated with cancer and neurodegeneration. To gain insight into the vital functions of FUS and how a loss of FUS function impacts cellular homeostasis
Moinecha Madi et al.
The Journal of membrane biology, 248(5), 903-908 (2015-03-20)
DNA electrotransfer is a successful technic for gene delivery. However, its use in clinical applications is limited since little is known about the mechanisms governing DNA electrotransfer in the complex environment occurring in a tissue. The objectives of this work
Erik S Barton et al.
Journal of virology, 88(21), 12740-12751 (2014-08-22)
Unlike laboratory animals, humans are infected with multiple pathogens, including the highly prevalent herpesviruses. The purpose of these studies was to determine the effect of gammaherpesvirus latency on T cell number and differentiation during subsequent heterologous viral infections. Mice were
Michaela Herrmann et al.
European biophysics journal : EBJ, 44(7), 503-512 (2015-05-29)
Bilayer mechanical properties are not only of crucial importance to the mechanism of action of mechanosensation in lipid membranes but also affect preparative laboratory tasks such as membrane-protein refolding. We report this for coupled refolding and bilayer insertion of outer membrane
Kosuke Endo et al.
Journal of gastroenterology and hepatology, 30(5), 944-951 (2014-12-24)
Rejection of liver grafts is a difficult issue that has not been resolved. Preoperative replacement of liver cells in the graft with cells from the intended recipient may attenuate rejection. We investigated whether preoperative transplant of recipient bone marrow cells
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