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Calcium intake, calcium homeostasis and health.
Fan P, et al.
Food science and human wellness, 5(1), 8-16 (2016)
Kang Liu et al.
International journal of molecular medicine, 45(6), 1793-1802 (2020-04-03)
Calbindin‑D28K (Calb1) may protect human lens epithelial cells (HLECs) from apoptosis, which is a process resulting in individual cell death. The protective effects of Calb1 may be attributed to buffering high concentrations of Ca2+. The present study investigated the mechanisms
Triptolide inhibits proliferation, differentiation and induces apoptosis of osteoblastic MC3T3-E1 cells
Wei J, et al.
Molecular Medicine Reports, 7391-7397 (2017)
Kathryn M Thrailkill et al.
Bone, 82, 101-107 (2015-07-28)
Persons with type 1 and type 2 diabetes have increased fracture risk, attributed to deficits in the microarchitecture and strength of diabetic bone, thought to be mediated, in part, by the consequences of chronic hyperglycemia. Therefore, to examine the effects
Kathryn M Thrailkill et al.
Bone, 133, 115254-115254 (2020-01-29)
Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of hyperglycemia among persons with type 2 diabetes (T2D). Despite favorable effects on cardiovascular events, specific SGLT2Is have been associated with an increased
Caiqin Sun et al.
The Journal of international medical research, 49(2), 300060521993315-300060521993315 (2021-03-02)
Myocardial ischemia/reperfusion (I/R) injury causes various severe heart diseases, including myocardial infarction. This study aimed to determine the therapeutic effect of atractylenolide I (ATR-I), which is an active ingredient isolated from Atractylodes macrocephala, on myocardial I/R injury. Male Sprague-Dawley rats
Creatine?facilitated protection of stress caused by disrupted circadian rhythm
George B, et al.
Biological Rhythm Research, 49(1), 61- 75 (2018)
Yuan Zhang et al.
BMC plant biology, 20(1), 221-221 (2020-05-20)
Arabinogalactan-proteins (AGPs) are one of the most complex protein families in the plant kingdom and are present in the cell walls of all land plants. AGPs are implicated in diverse biological processes such as plant growth, development, reproduction, and stress
Qianqian Dong et al.
European journal of pharmacology, 880, 173165-173165 (2020-05-20)
Vascular calcification is a highly regulated process similar to osteogenesis involving phenotypic change of vascular smooth muscle cells (VSMCs). 25-Hydroxycholesterol (25-HC), one of oxysterols synthesized by the enzyme cholesterol 25-hydroxylase, has been shown to promote bovine calcifying vascular cells (CVC)
Wei Ji et al.
Molecular medicine reports, 16(5), 7391-7397 (2017-09-26)
Ankylosing spondylitis (AS) is characterized by the formation of bony spurs. Treatment of the resulting ankylosis, excessive bone formation and associated functional impairment, remain the primary therapeutic aims in research regarding this condition. Triptolide is the primary active component of
Antonia E Schantl et al.
Nature communications, 11(1), 721-721 (2020-02-07)
Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors, among
Huaiyong Zhang et al.
Journal of animal science and biotechnology, 12(1), 104-104 (2021-10-09)
Alterations in ambient temperature have been associated with multiple detrimental effects on broilers such as intestinal barrier disruption and dysbiosis resulting in systemic inflammation. Inflammation and 25-hydroxycholecalciferol (25-OH-D3) have shown to play a negative and positive role, respectively, in the
Matthias B Moor et al.
PloS one, 15(7), e0236361-e0236361 (2020-07-25)
MEdiator of cell MOtility1 (MEMO1) is a ubiquitously expressed redox protein involved in extracellular ligand-induced cell signaling. We previously reported that inducible whole-body Memo1 KO (cKO) mice displayed a syndrome of premature aging and disturbed mineral metabolism partially recapitulating the
Dasmeet Kaur et al.
BMC plant biology, 21(1), 590-590 (2021-12-15)
Arabinogalactan-proteins (AGPs) are structurally complex hydroxyproline-rich cell wall glycoproteins ubiquitous in the plant kingdom. AGPs biosynthesis involves a series of post-translational modifications including the addition of type II arabinogalactans to non-contiguous Hyp residues. To date, eight Hyp-galactosyltransferases (Hyp-GALTs; GALT2-GALT9) belonging
Farhan Aslam et al.
Journal of medicinal food, 20(5), 448-457 (2017-03-24)
White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO
Daniel P Birnbaum et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(11), 2004699-2004699 (2021-06-19)
Bacterial cellulose (BC) has excellent material properties and can be produced sustainably through simple bacterial culture, but BC-producing bacteria lack the extensive genetic toolkits of model organisms such as Escherichia coli (E. coli). Here, a simple approach is reported for
Isopsoralen ameliorates H2O2-induced damage in osteoblasts via activating the Wnt/β-catenin pathway.
Yu-Peng Li et al.
Experimental and therapeutic medicine, 18(3), 1899-1906 (2019-08-15)
Osteoporosis is a disease with a worldwide prevalence that involves a severe loss of bone mineral density and decreased microarchitecture, which increases the risk of bone fracture. The present study evaluated the effects of isopsoralen on osteoblastic OB-6 cells following
Oyeyemi O Ajayi et al.
BMC plant biology, 21(1), 245-245 (2021-05-31)
Arabinogalactan-proteins (AGPs) are heavily glycosylated with type II arabinogalactan (AG) polysaccharides attached to hydroxyproline residues in their protein backbone. Type II AGs are necessary for plant growth and critically important for the establishment of normal cellular functions. Despite the importance
Kathryn M Thrailkill et al.
Bone, 94, 141-151 (2016-12-19)
Skeletal co-morbidities in type 1 diabetes include an increased risk for fracture and delayed fracture healing, which are intertwined with disease duration and the presence of other diabetic complications. As such, chronic hyperglycemia is undoubtedly a major contributor to these
Yunhui Liu et al.
Nature communications, 13(1), 771-771 (2022-02-11)
Parathyroid hormone (PTH) plays crucial role in maintaining calcium and phosphorus homeostasis. In the progression of secondary hyperparathyroidism (SHPT), expression of calcium-sensing receptors (CaSR) in the parathyroid gland decreases, which leads to persistent hypersecretion of PTH. How to precisely manipulate
Nadia M Morsi et al.
Drug development and industrial pharmacy, 45(5), 787-804 (2019-01-24)
Hydrogels forming in-situ have gained great attention in the area of bone tissue engineering recently, they were also showed to be a good and less invasive alternative to surgically applied ones. The primal focus of this study was to prepare
Andrey Zakharchenko et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(6) (2022-02-09)
Bioprosthetic heart valves (BHV) fabricated from glutaraldehyde-fixed heterograft tissue, such as bovine pericardium (BP), are widely used for treating heart valve disease, a group of disorders that affects millions. Structural valve degeneration (SVD) of BHV due to both calcification and
Tianran Zhang et al.
Redox biology, 38, 101828-101828 (2020-12-19)
Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. Liver kinase B1 (LKB1) plays pivotal roles in cellular processes such as apoptosis, metabolism, and cell cycle regulation. In addition, growing evidence has indicated
Tianran Zhang et al.
Journal of molecular and cellular cardiology, 142, 39-52 (2020-04-09)
Vascular calcification is a pathological process closely related to atherosclerosis, diabetic vascular diseases, vascular injury, hypertension, chronic kidney disease and aging. Lethal giant larvae 1 (LGL1) is known as a key regulator of cell polarity and plays an important role
Santiago Pech-Pool et al.
International journal of molecular sciences, 21(4) (2020-02-26)
It is known that growth hormone (GH) is expressed in immune cells, where it exerts immunomodulatory effects. However, the mechanisms of expression and release of GH in the immune system remain unclear. We analyzed the effect of growth hormone-releasing hormone
Aijaz Ahmad John et al.
Molecular therapy. Nucleic acids, 29, 296-311 (2022-08-12)
Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited therapeutic effects because osteoblast-mediated bone formation decreases concurrently. We developed a
Jing Che et al.
Life sciences, 182, 10-21 (2017-06-12)
The study aims to investigate the effects of Periostin gene silencing on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer (LC). LC patients were divided into bone metastasis and non-bone metastasis groups; Healthy volunteers were selected
Pengcheng He et al.
Vascular pharmacology, 132, 106775-106775 (2020-07-24)
Medial artery calcification (MAC) significantly contributes to the increased cardiovascular death in patients with chronic kidney disease (CKD). Previous genome-wide association studies have shown that various genetic variants of the histone deacetylase Hdac9 are associated with cardiovascular disease, but the
Ruth Edwige Kemadjou Dibacto et al.
Heliyon, 8(7), e09896-e09896 (2022-07-21)
Neurodegenerative disease such as Alzheimer's disease, are progressive disorders which has been linked to oxidative imbalance and associated perturbations characterised by loss of memory, cognition and cholinergic deficit. To date, cholinesterase inhibition and neuroprotection are the two major strategies in
Srividhya Iyer et al.
FASEB bioAdvances, 2(4), 207-218 (2020-04-08)
Increased production of the osteoclastogenic cytokine RANKL is a common feature of pathologic bone loss, but the underlying cause of this increase is poorly understood. The unfolded protein response (UPR) is activated in response to accumulation of misfolded proteins in
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