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Romaric Lacroix et al.
Seminars in thrombosis and hemostasis, 39(1), 33-39 (2013-01-11)
Microparticles (MPs) are small vesicles resulting from the shedding of cellular membrane during activation or apoptosis processes. Beyond their well-described procoagulant property, accumulating data show that specific endothelial cell-, leukocyte-, tumor-derived MPs bind plasminogen and vectorize plasminogen activators, leading to
Injectable drug may help avoid eye surgery in patients with vitreomacular adhesion.
Thomas Morrow
Managed care (Langhorne, Pa.), 22(1), 49-50 (2013-02-05)
Hyo Jung Park et al.
Immunology, 140(1), 133-141 (2013-05-25)
Haptoglobin (Hp), a major acute-phase plasma protein, has been found in arthritic synovial fluid (SF). However, the function and structural modifications of Hp in arthritic SF are unknown. To investigate in vivo generation of modified Hp associated with inflammatory disease
Emma-Karin I Millers et al.
PloS one, 8(1), e54104-e54104 (2013-01-22)
Textilinin-1 is a Kunitz-type serine protease inhibitor from Australian brown snake venom. Its ability to potently and specifically inhibit human plasmin (K(i) = 0.44 nM) makes it a potential therapeutic drug as a systemic anti-bleeding agent. The crystal structures of
Rishi P Singh et al.
The British journal of ophthalmology, 98(3), 356-360 (2013-12-21)
To evaluate the anatomical and visual outcomes of patients treated with ocriplasmin for the treatment of symptomatic vitreomacular adhesion (sVMA), including vitreomacular traction syndrome and macular holes. Retrospective, interventional, single centre, case series. Patients with sVMA. Patients were treated with
Silke Haerteis et al.
The Journal of general physiology, 140(4), 375-389 (2012-09-12)
Proteolytic activation of the epithelial sodium channel (ENaC) involves cleavage of its γ subunit in a critical region targeted by several proteases. Our aim was to identify cleavage sites in this region that are functionally important for activation of human
Ayelet Sarah Hershkovits et al.
Frontiers in aging neuroscience, 15, 1171123-1171123 (2023-06-02)
Accumulation of amyloid β in the brain is regarded as a key initiator of Alzheimer's disease pathology. Processing of the amyloid precursor protein (APP) in the amyloidogenic pathway yields neurotoxic amyloid β species. In the non-amyloidogenic pathway, APP is processed
Gabriela H Siqueira et al.
The American journal of tropical medicine and hygiene, 89(6), 1103-1116 (2013-08-21)
We report cloning, expression, purification, and characterization of three predicted leptospiral membrane proteins (LIC11360, LIC11009, and LIC11975). In silico analysis and proteinase K accessibility data suggest that these proteins might be surface exposed. We show that proteins encoded by LIC11360
An-Chun Cheng et al.
Biochimica et biophysica acta, 1840(1), 153-159 (2013-09-04)
Snake venoms are rich in Kunitz-type protease inhibitors that may have therapeutic applications. However, apart from trypsin or chymotrypsin inhibition, the functions of most of these inhibitors have not been elucidated. A detailed functional characterization of these inhibitors may lead
Hadi Kooshiar et al.
Dermatologic therapy, 25(6), 621-625 (2012-12-06)
Formation of necrotic tissues is a major issue affecting treatment of full-thickness burns. This study was designed to compare topical effectiveness of applying kiwifruit versus fibrinolysin on removal of necrotic tissue of burns. Ten adult male Wistar rats were randomly
Morgan L Locy et al.
Science signaling, 13(644) (2020-08-14)
The oxidation of tyrosine residues to generate o,o'-dityrosine cross-links in extracellular proteins is necessary for the proper function of the extracellular matrix (ECM) in various contexts in invertebrates. Tyrosine oxidation is also required for the biosynthesis of thyroid hormone in
Rabbit plasminogen and plasmin isozymes.
F J Castellino et al.
Methods in enzymology, 45, 273-286 (1976-01-01)
Sara Raimondi et al.
The Journal of biological chemistry, 295(33), 11379-11387 (2020-06-24)
Systemic amyloidosis caused by extracellular deposition of insoluble fibrils derived from the pathological aggregation of circulating proteins, such as transthyretin, is a severe and usually fatal condition. Elucidation of the molecular pathogenic mechanism of the disease and discovery of effective
M Codenotti et al.
Eye (London, England), 27(1), 22-27 (2012-12-15)
To evaluate the effects of intravitreal autologous plasmin enzyme (APE) in patients with focal vitreomacular traction (VMT). APE was obtained by incubation of patient-derived purified plasminogen with streptokinase, and intravitreally injected 5-12 days later. Twenty-four hours after injection, in case
Woo-Soo Jeong et al.
Microorganisms, 11(6) (2023-06-28)
Traditional yeast (Saccharomyces cerevisiae) has been used for its benefits in various fermentation processes; the benefits of non-Saccharomyces yeast as a material for food, feed, and pharmaceuticals have been studied recently. This study evaluated the anti-inflammatory activity and extracellular functional
Fengtian Xue et al.
Bioorganic & medicinal chemistry, 14(24), 8467-8487 (2006-09-15)
Three series of cyclic ketone inhibitors were synthesized and evaluated against the serine protease plasmin. Peptide inhibitors that incorporated 3-oxotetrahydrofuran and 3-oxotetrahydrothiophene 1,1-dioxide groups had the highest activities. Alkylamino substituents, which were designed to bind in the S1 subsite of
Kwang Soo Kim et al.
The Journal of biological chemistry, 287(30), 24862-24872 (2012-05-24)
Parkinson disease (PD) is the second most common neurodegenerative disease characterized by a progressive dopaminergic neuronal loss in association with Lewy body inclusions. Gathering evidence indicates that α-synuclein (α-syn), a major component of the Lewy body, plays an important role
D H W Steel et al.
Eye (London, England), 27 Suppl 1, S1-21 (2013-10-11)
Posterior vitreous detachment (PVD) is a common phenomenon in the aging eye. However, this may be complicated by persistent symptomatic vitreomacular adhesions that exert tractional forces on the macula (vitreomacular traction; VMT). VMT itself may be associated with epiretinal membrane
J Z Dong et al.
Diabetes, obesity & metabolism, 13(1), 19-25 (2010-12-01)
Glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes are administered by daily injection because of short plasma half-lives, which result partly from the biochemical instability of these peptides. There is a medical need for GLP-1 analogues
E S Shipko et al.
Klinicheskaia laboratornaia diagnostika, (11)(11), 57-59 (2013-01-12)
The article discusses the technique of defining the strains of comma bacillus according their capability to convert human plasminogen into plasmin in vitro. This method can be implemented in applied and fundamental research concerning the study of subtle mechanisms of
On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin.
B Wiman et al.
The Journal of biological chemistry, 254(18), 9291-9297 (1979-09-25)
Composite Fibrin and Carbon Microfibre Implant to Modulate Postraumatic Inflammation after Spinal Cord Injury.
Escarrat, et al.
Cells, 12 (2023)
Marcus Fulde et al.
Frontiers in cellular and infection microbiology, 3, 85-85 (2013-12-10)
The ability to take advantage of plasminogen and its activated form plasmin is a common mechanism used by commensal as well as pathogenic bacteria in interaction with their respective host. Hence, a huge variety of plasminogen binding proteins and activation
Miranda Nolan et al.
The Journal of biological chemistry, 288(41), 29482-29493 (2013-08-24)
Our previously hypothesized mechanism for the pathway of plasminogen (Pg) activation by streptokinase (SK) was tested by the use of full time course kinetics. Three discontinuous chromogenic substrate initial rate assays were developed with different quenching conditions that enabled quantitation
Dong-Yun Lee et al.
Maturitas, 76(1), 75-80 (2013-07-06)
The rhizome of the Cimicifuga racemosa plant (commonly known as black cohosh) has been used for menopausal complaints. Studies regarding the cardiovascular effects of black cohosh are lacking. We investigated the effect of black cohosh on the plasminogen activator system
Dejun Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(33) (2021-08-13)
Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function
Lucas R de Souza et al.
Biochemical and biophysical research communications, 433(3), 333-337 (2013-03-19)
Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3
Yue Shen et al.
PloS one, 7(12), e51303-e51303 (2012-12-14)
Mice deficient in plasminogen, the precursor of plasmin, show completely arrested healing of tympanic membrane (TM) perforations, indicating that plasmin plays an essential role in TM healing. The activation of plasminogen to plasmin is performed by two plasminogen activators (PAs)
Gregory S Bryman et al.
Neuron, 108(2), 335-348 (2020-08-28)
The fovea is a neural specialization that endows humans and other primates with the sharpest vision among mammals. This performance originates in the foveal cones, which are extremely narrow and long to form a high-resolution pixel array. Puzzlingly, this form
Siqi Gao et al.
Hepatology (Baltimore, Md.), 68(5), 1991-2003 (2018-05-08)
The serine protease plasmin degrades extracellular matrix (ECM) components both directly and indirectly through activation of matrix metalloproteinases. Excessive plasmin activity and subsequent ECM degradation cause hepatic sinusoidal fragility and hemorrhage in developing embryos. We report here that excessive plasmin
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