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PHR1008
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Jin Gu Cho et al.
Stem cells (Dayton, Ohio), 33(3), 792-805 (2014-11-20)
Although serum bile acid concentrations are approximately 10 µM in healthy subjects, the crosstalk between the biliary system and vascular repair has never been investigated. In this study, tauroursodeoxycholic acid (TUDCA) induced dissociation of CD34(+) hematopoietic stem cells (HSCs) from
Sean Austin O Lim et al.
Neurobiology of disease, 76, 67-76 (2015-02-11)
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of L-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergic interneurons (ChIs) in mice expressing
Jinfeng Hou et al.
BioMed research international, 2014, 850493-850493 (2014-07-22)
FLZ (N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2,5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide) is a novel synthetic squamosamide derivative and a potential anti-Parkinson's disease (PD) agent. The objective of the present study was to investigate the penetration of free FLZ across the BBB and the effects of P-gp inhibition on FLZ
Chen Qi et al.
International journal of molecular medicine, 34(2), 440-450 (2014-06-19)
The purpose of this study was to determine the effectiveness of the systemic administration of high dose erythropoietin (EPO) in a 6‑hydroxydopamine (6‑OHDA)‑ induced rat model. Rats were divided into 7 groups. Groups 1‑4 were administered daily EPO doses of
M Jannasch et al.
Experimental parasitology, 150, 22-30 (2015-01-17)
Investigation of percutaneous helminth infection is generally based on animal models or excised skin. As desirable replacement of animal experiments, tissue-engineered skin equivalents have recently been applied in microbial and viral in vitro infection models. In the present study, the
Jianbo Sun et al.
Journal of ethnopharmacology, 159, 296-300 (2014-07-06)
Dictamnus angustifolius (Rutaceae) has been used as an alternative for folk medicine, Dictamnus dasycarpus in the treatment of rheumatism, bleeding, itching, jaundice, chronic hepatitis, and skin diseases in Xinjiang Province of China. The aim of this study was to evaluate
Hichame Id Boufker et al.
BMC cancer, 10, 298-298 (2010-06-23)
The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast activity, and, as such, its inhibition is a potential means to prevent bone loss.
Shuang Yang et al.
BMC molecular biology, 16, 1-1 (2015-04-19)
The glomerular podocyte is a highly specialized cell type with the ability to ultrafilter blood and support glomerular capillary pressure. However, little is known about the genetic programs leading to this functionality or the final phenotype. In the current study
Francisca Rodrigues et al.
Pharmaceutical biology, 53(3), 386-394 (2014-12-05)
Currently, there is a great tendency in cosmetic area to use natural extracts. Coffee silverskin (CS) is the most abundant solid by-product generated during roasting of coffee processing. To evaluate different CS extracts as promising cosmetic ingredients, regarding antioxidant, antimicrobial
Chi-Kai Chiu et al.
Journal of materials science. Materials in medicine, 26(2), 92-92 (2015-02-05)
Low mechanical strengths and inadequate bioactive material-tissue interactions of current synthetic materials limit their clinical applications in bone regeneration. Here, we demonstrate gelatin modified siloxane-calcium silicate (GEMOSIL-CS), a nanocomposite made of gelatinous hydroxyapatite with in situ pozzolanic formation of calcium
Yan Zhu et al.
Food science and technology international = Ciencia y tecnologia de los alimentos internacional, 19(4), 291-303 (2013-06-05)
Patulin is a mycotoxin produced by a wide range of molds involved in fruit spoilage, most commonly by Penicillium expansum and is a health concern for both consumers and manufacturers. The current study evaluated feasibility of monochromatic ultraviolet (UV) radiation
Khaled Abdallah et al.
Pain, 156(4), 644-655 (2015-03-20)
Descending pain-modulatory systems, either inhibitory or facilitatory, play a critical role in both acute and chronic pain. Compared with serotonin and norepinephrine, little is known about the function of dopamine (DA). We characterized the anatomical organization of descending DA pathways
Hossein Nejadnik et al.
Stem cell reviews and reports, 11(2), 242-253 (2015-01-13)
Human induced pluripotent stem cells (hiPSCs) have demonstrated great potential for hyaline cartilage regeneration. However, current approaches for chondrogenic differentiation of hiPSCs are complicated and inefficient primarily due to intermediate embryoid body formation, which is required to generate endodermal, ectodermal
E Torreggiani et al.
European cells & materials, 28, 137-151 (2014-09-23)
Despite the popularity of platelet-rich plasma (PRP) and platelet lysate (PL) in orthopaedic practice, the mechanism of action and the effectiveness of these therapeutic tools are still controversial. So far, the activity of PRP and PL has been associated with
M W Roomi et al.
International journal of oncology, 44(3), 986-992 (2014-01-01)
Strong clinical and experimental evidence demonstrates association of elevated levels of matrix metalloproteinase MMP-9 with cancer progression, metastasis and shortened patient survival, as it plays a key role in tumor cell invasion and metastasis by digesting the basement membrane and
Yang-peng Sun et al.
PloS one, 9(7), e101896-e101896 (2014-07-09)
Multipotent mesenchymal stem cells (MSCs) found in the synovial fluid (SFMSCs) of the tempromandibular joint (TMJ) remain poorly understood. During TMJ arthrocentesis, we discovered that synovial fluid collected from some patients with TMJ disorders contained not only SFMSCs but also
Ye Li et al.
Biochemical and biophysical research communications, 454(2), 257-261 (2014-10-12)
Degradation of collagen type II caused by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) is one of the major pathological characteristics of osteoarthritis (OA). Dimethyl fumarate (DMF) is a medication approved by the US Food and Drug Administration
Dandan Liang et al.
Journal of cellular and molecular medicine, 18(9), 1830-1839 (2014-06-04)
Tetralogy of Fallot (TOF) is a complex congenital heart defect and the microRNAs regulation in TOF development is largely unknown. Herein, we explored the role of miRNAs in TOF. Among 75 dysregulated miRNAs identified from human heart tissues, miRNA-940 was
Eduardo Henrique Silva Sousa et al.
Journal of inorganic biochemistry, 140, 236-244 (2014-09-06)
Tuberculosis has re-emerged as a worldwide threat, which has motivated the development of new drugs. The antituberculosis complex Na3[Fe(CN)5(isoniazid)] (IQG607) in particular is of interest on account of its ability to overcome resistance. IQG607 has the potential for redox-mediated-activation, in
N Takeuchi et al.
Oral diseases, 21(1), 113-122 (2014-02-06)
Granulocyte-colony stimulating factor (G-CSF) has been shown to have combinatorial trophic effects with dental pulp stem cells for pulp regeneration. The aim of this investigation is to examine the effects of basic fibroblast growth factor (bFGF) in vitro and in
Rebecca S Hofford et al.
Behavioural brain research, 270, 151-158 (2014-05-14)
Environmental factors influence a variety of health-related outcomes. In general, being raised in an environment possessing social, sensory, and motor enrichment reduces the rewarding effects of various drugs, thus protecting against abuse vulnerability. However, in the case of methamphetamine (METH)
Fabio Bucchieri et al.
PloS one, 10(3), e0120510-e0120510 (2015-03-21)
Epidemiologic studies have demonstrated important links between air pollution and asthma. Amongst these pollutants, environmental cigarette smoke is a risk factor both for asthma pathogenesis and exacerbation. As the barrier to the inhaled environment, the bronchial epithelium is a key
Kristen M Lynch et al.
Tissue engineering. Part A, 20(23-24), 3122-3129 (2014-05-24)
The capacity to regenerate complex tissue structures after amputation in humans is limited to the digit tip. In a comparable mouse digit model, which includes both distal regeneration-competent and proximal regeneration-incompetent regions, successful regeneration involves precise orchestration of complex microenvironmental
Hwa-Jin Chung et al.
BMC complementary and alternative medicine, 14, 184-184 (2014-06-07)
JSOG-6 is used as a traditional medicine to relieve the symptoms associated with inflammation, rheumatism, and osteoporosis in Korea. In the present study, we investigated the effects of JSOG-6 on bone loss prevention both in in vitro and in vivo
Alberto Soriano-Maldonado et al.
European journal of nutrition, 53(8), 1645-1657 (2014-02-18)
The aim of the present study was to investigate the effects of the consumption of two cloudy apple juices with different polyphenol and vitamin C contents on antioxidant status, cardiometabolic and inflammation markers in healthy young adults. Twenty subjects, aged
Erin M Miller et al.
Psychopharmacology, 231(15), 3019-3029 (2014-04-01)
Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased stimulation of dopamine
Gregory Tour et al.
Journal of tissue engineering and regenerative medicine, 8(11), 841-849 (2012-07-12)
We aimed to investigate the osteogenic properties of bone marrow stromal cell (BMSC)-loaded biomimetic constructs composed of hydroxyapatite (HA), with or without in vitro cell-derived extracellular matrix (HA-ECM), and to assess the cellular components of the elicited foreign body reaction.
Akihiro Tai et al.
Bioscience, biotechnology, and biochemistry, 78(10), 1723-1730 (2014-10-03)
The antioxidative properties of ascorbigen, one of the major indole-derived compounds of Brassica vegetables, were systematically evaluated using multiple assay systems with comparison to the well-known antioxidants ascorbic acid and Trolox. We first performed assays using model radicals, DPPH radical
Li Zhen Zhang et al.
Food chemistry, 174, 495-501 (2014-12-23)
Commonly consumed foxtail millet varieties Jingu28 and Jingu34 were compared in terms of phytochemical composition, antioxidant property, and antiproliferative activity. The cellular antioxidant activity (CAA) was evaluated based on HepG2 cell cultivation. Antiproliferative properties against HepG2 and MDA cell were
Yong-Soo Byun et al.
PloS one, 9(11), e112781-e112781 (2014-11-11)
Corneal stromal cells transform to precursor cells in spheroid culture. We determined whether keratocytes derived from spheroid culture of murine corneal stromal cells resemble tissue resident keratocytes. Spheroid culture was performed by seeding dissociated stromal cells onto ultra-low attachment plates
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