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PHR1396
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Tapan M Kadia et al.
American journal of hematology, 90(2), 120-124 (2014-11-05)
Newer approaches are needed for the treatment of relapsed and refractory acute lymphoblastic leukemia (ALL). Asparaginase-based regimens are active in the treatment of pediatric ALL and may be important in salvage therapy for adult patients. We conducted a pilot trial
Reply of the authors.
Christina E Boots et al.
Fertility and sterility, 101(4), e24-e24 (2014-02-19)
Paul Emery et al.
The New England journal of medicine, 371(19), 1781-1792 (2014-11-06)
We assessed the effects of reduction and withdrawal of treatment in patients with rheumatoid arthritis who had a remission while receiving etanercept-plus-methotrexate therapy. Patients with early active disease who had not previously received methotrexate or biologic therapy received 50 mg
Joshua F Baker et al.
Annals of the rheumatic diseases, 73(11), 1968-1974 (2013-08-02)
To determine if early MRI measures predict X-ray progression at 1 and 2 years in a large RA trial cohort. This study included 256 methotrexate (MTX)-naïve RA patients from a randomised placebo-controlled trial of golimumab (GO-BEFORE). MRIs of wrist and 2nd-5th
Kalle Jyri Aaltonen et al.
The Journal of rheumatology, 42(3), 372-378 (2015-01-17)
Because of the role of tumor necrosis factor (TNF) in host defense, it was hypothesized that its inhibition might lead to an increased risk of malignancies and infections. The objective of our study was to assess the incidence of serious
Mohamed Badr et al.
Biological chemistry, 395(12), 1461-1466 (2014-09-11)
An immunotoxin composed of gelonin, a basic ribosome-inactivating protein, type I of 30 kDa, isolated from the seeds of the Indian plant Gelonium multiflorum and methotrexate (MTX) has been studied as a potential tool of gelonin delivery into the cytoplasm
Coxiella burnetii infection (Q fever) in rheumatoid arthritis patients with and without anti-TNFα therapy.
T Schoffelen et al.
Annals of the rheumatic diseases, 73(7), 1436-1438 (2014-05-06)
Toward a practical renaming of bullous pemphigoid and all its variants: cutaneous pemphigoid.
Luca Borradori et al.
JAMA dermatology, 150(4), 459-459 (2014-04-11)
Shun-suke Tanaka et al.
PloS one, 9(7), e103439-e103439 (2014-07-26)
The gene amplification plays a critical role in the malignant transformation of mammalian cells. The most widespread method for amplifying a target gene in cell culture is the use of methotrexate (Mtx) treatment to amplify dihydrofolate reductase (Dhfr). Whereas, we
Maria E C Sandberg et al.
Annals of the rheumatic diseases, 73(11), 2029-2033 (2014-05-14)
To investigate whether overweight/obesity at diagnosis affects the chances of decrease in disease activity and pain in early rheumatoid arthritis (RA). We investigated incident RA cases from the population-based Epidemiological Investigation of risk factors for Rheumatoid Arthritis (EIRA) study (2006-2009
Shilpen A Patel et al.
American journal of clinical oncology, 38(1), 47-50 (2015-01-24)
Malignant pleural mesothelioma (MPM) is a fatal disease lacking standardized treatment. We describe the use of fast neutron radiation therapy in MPM patients referred to the Department of Radiation Oncology at the University of Washington Medical Center. Retrospective chart review
Paying attention to the preciseness of conclusion.
Kai Yuan et al.
Annals of the rheumatic diseases, 73(11), e66-e66 (2014-07-20)
Response to H Zeidler's comments on the CONCERTO study.
Gerd R Burmester et al.
Annals of the rheumatic diseases, 73(8), e51-e51 (2014-06-11)
Koya Fushimi et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 41(4), 449-453 (2014-04-20)
Japanese clinical trials of a tegafur/uracil(UFT)-based postoperative chemotherapy regimen compared with cyclophosphamide, methotrexate, and fluorouracil(CMF)treatment have shown that UFT is not inferior to CMF for the treatment of hormone receptor-positive breast cancer patients. However, the usefulness of UFT for hormone
Mai Furumiya et al.
Drug metabolism and pharmacokinetics, 29(4), 312-316 (2014-02-05)
Myricetin is a flavonoid that has recently been suggested to interfere with the intestinal folate transport system. The present study was conducted to examine that possibility, focusing on its inhibitory effect on proton-coupled folate transporter (PCFT) as the molecular entity
Benjamin Boucherle et al.
European journal of medicinal chemistry, 83, 455-465 (2014-07-06)
Cystic fibrosis transmembrane conductance regulator (CFTR) is the main chloride channel present in the apical membrane of epithelial cells and the F508 deletion (F508del-CFTR) in the CF gene is the most common cystic fibrosis-causing mutation. In the search for a
Etanercept tapering in rheumatoid arthritis.
Paul Emery et al.
The New England journal of medicine, 372(5), 489-490 (2015-01-30)
Nathalie K Zgheib et al.
Pharmacogenetics and genomics, 24(8), 387-396 (2014-07-10)
The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess
Ajay Vora et al.
The Lancet. Oncology, 15(8), 809-818 (2014-06-14)
No randomised study has shown whether stratification of treatment by minimal residual disease (MRD) response improves outcome in children and young people with acute lymphoblastic leukaemia (ALL). We assessed whether children and young people with clinical standard and intermediate-risk ALL
Mette Levinsen et al.
Cancer chemotherapy and pharmacology, 75(1), 59-66 (2014-10-29)
Through enhancement of 6-mercaptopurine (6MP) bioavailability and inhibition of purine de novo synthesis, high-dose methotrexate (HD-MTX) may increase incorporation into DNA of 6-thioguanine nucleotides, the cytotoxic metabolites of 6MP. Patients with intermediate activity of thiopurine methyltransferase (TPMT(IA)) have higher cytosol
Michael E Rytting et al.
Cancer, 120(23), 3660-3668 (2014-07-22)
Various trials have reported improved outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) who received treatment with pediatric-based regimens. Those reports prompted the current investigation of the pediatric augmented Berlin-Frankfurt-Münster (ABFM) regimen in AYA patients. The
Lama Azar et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(10), 2862-2870 (2014-06-20)
To evaluate the efficacy and safety of rituximab (RTX) induction therapy and the duration of remission, when RTX is used with or without a conventional maintenance agent, in a cohort of patients with granulomatosis with polyangiitis (Wegener's) (GPA). This was
Rongrong Jiang et al.
British journal of pharmacology, 172(4), 1059-1073 (2014-10-10)
Ginsenosides are bioactive saponins derived from Panax notoginseng roots (Sanqi) and ginseng. Here, the molecular mechanisms governing differential pharmacokinetics of 20(S)-protopanaxatriol-type ginsenoside Rg1 , ginsenoside Re and notoginsenoside R1 and 20(S)-protopanaxadiol-type ginsenosides Rb1, Rc and Rd were elucidated. Interactions of
Marguerite S Joly et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3947-3958 (2014-09-12)
Biologic drugs, including enzyme-replacement therapies, can elicit anti-drug Abs (ADA) that may interfere with drug efficacy and impact patient safety. In an effort to control ADA, we focused on identifying regimens of immune tolerance induction that may be readily available
Rym Chioukh et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2041-2048 (2014-09-23)
The coadministration of methotrexate (MTX) and proton pump inhibitors (PPIs) can result in a pharmacokinetic interaction that delays MTX elimination and subsequently increases the MTX blood concentrations. Human organic anion transporters (hOATs) are responsible for the renal tubular secretion of
Ines Truebenbach et al.
Molecular pharmaceutics, 16(6), 2405-2417 (2019-04-27)
In the current study, nanoparticles containing the antimetabolite drug methotrexate (MTX) and the novel tubulin-binding drug pretubulysin (PT) were developed for combination chemotherapy. Polyelectrolyte complexes were formed based on ∼20 nm cationic nanomicelles of lipo-oligomer 454 with the anionic MTX
Daisy Puttevils et al.
Acta cardiologica, 69(2), 111-118 (2014-05-03)
Patients with established rheumatoid arthritis (RA) have a higher cardiovascular morbidity and mortality in comparison with the general population. It is considered to be an independent risk factor for cardiovascular disease. The purpose of this article is to describe the
Cutaneous Rosai-Dorfman disease successfully treated with low-dose methotrexate.
Natalie Z Sun et al.
JAMA dermatology, 150(7), 787-788 (2014-05-03)
J Bluett et al.
The Analyst, 140(6), 1981-1987 (2015-02-12)
Rheumatoid arthritis (RA) is a common autoimmune disease that causes significant disability and reduced life expectancy. The folate antagonist methotrexate (MTX) is first-line therapy for RA when used weekly at low doses (5-25 mg). However, the true rate of adherence
Chen Lossos et al.
British journal of haematology, 165(5), 640-648 (2014-02-28)
Primary central nervous system lymphoma (PCNSL) is an aggressive sub-variant of non-Hodgkin lymphoma (NHL) with morphological similarities to diffuse large B-cell lymphoma (DLBCL). While methotrexate (MTX)-based therapies have improved patient survival, the disease remains incurable in most cases and its
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