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S-010
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显示 1-30 #N/A 84 条结果 关于 "S-010" 范围 论文
Elif Damar et al.
American journal of men's health, 7(5), 439-443 (2013-03-13)
The possible effects of sildenafil citrate administration at therapeutic dosage on visual acuity, color vision, intraocular pressure, macular thickness, macular volume, and central serous chorioretinopathy in patients with erectile dysfunction were evaluated. The study consisted of 43 male patients diagnosed
B Ramírez-Mendiola et al.
Drug research, 63(9), 473-476 (2013-06-06)
The aim of this study was to develop a simple method for quantifying plasma levels of sildenafil and its metabolite by liquid chromatography with a C18 reverse-phase column and UV detection. For both compounds, linearity was assessed in the range
[Pharmacological treatment of pulmonary hypertension at a turning point].
Hiroshi Watanabe
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 143(4), 165-172 (2014-04-11)
Ali Kagan Gokakin et al.
Burns : journal of the International Society for Burn Injuries, 39(6), 1193-1199 (2013-01-15)
Severe burn induces biochemical mediators such as reactive oxygen species that leads to lipid peroxidation which may have a key role in formation of acute lung injury (ALI). Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific
Reply: To PMID 24837446.
Hongde Chen et al.
Urology, 84(1), 56-56 (2014-05-20)
Hyerang Roh et al.
Clinical therapeutics, 35(3), 205-214 (2013-03-19)
An orally disintegrating film (ODF) formulation of sildenafil was recently developed in Korea. This formulation is expected to enhance dosing convenience and increase patient compliance while yielding pharmacokinetics comparable to those of the conventional film-coated tablet (FCT) formulation. The goal
A S Tripathi et al.
Drug research, 63(10), 510-514 (2013-07-26)
A simple and sensitive method was developed for simultaneous estimation of Glimepiride (GLIM) and Sildenafil citrate (SIL) in rat Plasma by reverse phase high performance liquid chromatography (RP-HPLC). The drug samples were extracted by liquid-liquid extraction with 300 µl of
Ibrahim Yazji et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9451-9456 (2013-05-08)
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by severe intestinal necrosis and for which breast milk represents the most effective protective strategy. Previous studies have revealed a critical role for the lipopolysaccharide receptor toll-like receptor 4
Christina Danial et al.
Journal of the American Academy of Dermatology, 70(6), 1050-1057 (2014-03-25)
Lymphatic malformations can be challenging to treat. Mainstay interventions including surgery and sclerotherapy are invasive and can result in local recurrence and complications. We sought to assess the effect of 20 weeks of oral sildenafil on reducing lymphatic malformation volume
Christian P Pavlovich et al.
BJU international, 112(6), 844-851 (2013-08-14)
To clarify the role of phosphodiesterase type 5 (PDE5) inhibitors in post-prostatectomy penile rehabilitation (PPPR). To compare nightly and on-demand use of PDE5 inhibitors after nerve-sparing minimally invasive radical prostatectomy (RP). We conducted a single-institution, double-blind, randomized controlled trial of
Wenpeng Cui et al.
American journal of physiology. Renal physiology, 306(9), F996-1007 (2014-02-28)
Our previous studies support the protective effect of cGMP and cGMP-dependent protein kinase I (PKG-I) pathway on the development of renal fibrosis. Therefore, in the present studies, we determined whether pharmacologically or genetically increased PKG activity attenuates renal fibrosis in
[The prescription].
Jürgen Rabe
MMW Fortschritte der Medizin, 155(1), 28-28 (2013-04-12)
Ismail Ekinozu et al.
The American journal of emergency medicine, 31(9), 1424-1424 (2013-06-25)
Sildenafil is a drug used for male erectile dysfunction. Sildenafil's fatal cardiac effects except due to hypotension with simultaneous nitrate use have not been reported.We reported in this case a 70-year-old man admitted to the emergency service with chest pain
Udomsak Wijitsettakul et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(6), 683-688 (2013-08-21)
To evaluate the efficacy and safety of Elonza (generic product of sildenafil) 100 mg, a phosphodiesterase type 5 (PDE5) inhibitor, in Thai men with erectile dysfunction (ED). This prospective, Cohort study was conducted for eight weeks. Two hundred ten male
S Masciovecchio et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 65(3), 205-209 (2013-07-23)
In the recent literature, great attention has been given to the evaluation of the real effectiveness of the phosphodiesterase type 5 inhibitors (PDE-5i), usually prescribed for the erectile dysfunction (ED), in the treatment of the lower urinary tracts symptoms (LUTS).
Wael M Samy et al.
Expert opinion on drug delivery, 11(10), 1525-1536 (2014-06-19)
Study the possible benefit of combining biodegradable polymers with sildenafil citrate (SC) in wound healing. Biodegradable micronized powdered formulations of SC were prepared by spray drying using chitosan (P₁) or chitosan/gum Arabic (P₂). Powders were characterized by differential scanning calorimetry
Fan Lin et al.
European journal of cancer (Oxford, England : 1990), 49(8), 2059-2064 (2013-02-21)
Recently, sildenafil was reported to be an inhibitor of P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) in vitro. We have now investigated the in vivo potency of sildenafil. By using wild-type and Abcb1; Abcg2 knockout mice we have investigated
Kai Zhang et al.
Urology, 83(4), 831-836 (2014-04-01)
To evaluate the clinical efficacy of sildenafil for the improvement of penile erection hardness in erectile dysfunction (ED) patients and to determine the relationship between this improvement in erection hardness and social and psychological functioning. From 2007 to 2008, a
Svetlana Karakhanova et al.
Molecular immunology, 56(4), 649-659 (2013-08-06)
Phosphodiesterase 5 (PDE5) is a pharmacological target in erectile dysfunction, pulmonary hypertension and in other indications. In tumor-bearing mice an inhibition of PDE5 with sildenafil prolongs survival of the animals through the augmentation of antitumor immunity, indicating the immunomodulatory properties
Martins Ekor et al.
Journal of basic and clinical physiology and pharmacology, 24(1), 73-79 (2013-02-22)
Altered regulation of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) is present in liver cirrhosis. Several experimental studies have shown that selective modulation of NO metabolism in the liver reduces intrahepatic resistance and portal pressure in cirrhosis. This preliminary study investigated whether
Masahiro Enomoto et al.
American journal of physiology. Lung cellular and molecular physiology, 306(2), L207-L215 (2013-11-19)
Inhaled nitric oxide (NO) and other cGMP- or cAMP-dependent pulmonary vasodilators are often used in combination for the treatment of the persistent pulmonary hypertension of the newborn syndrome. There is in vitro evidence to indicate that NO downregulate the pulmonary
Temporal trends in use of sildenafil among pediatric patients.
Adnan T Bhutta et al.
American journal of respiratory and critical care medicine, 188(10), 1269-1271 (2013-11-19)
[Role of the Rho-kinase pathway in pulmonary arterial hypertension].
Yoshihiro Fukumoto
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 143(4), 178-181 (2014-04-11)
Stephanie Oger-Roussel et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(2), R108-R117 (2013-12-07)
Despite the fact that urogenito-sexual complications significantly impact the quality of life of diabetic patients, a robust in vivo experimental model is lacking. Bladder and erectile function in the Type 2 diabetic Goto-Kakizaki (GK) rat and responses to standard-of-care treatments
Hongde Chen et al.
Urology, 84(1), 51-56 (2014-05-20)
To evaluate the efficacy of daily low-dose sildenafil for the treatment of nonulcer interstitial cystitis (IC) in women. Forty-eight women with a clinical diagnosis of IC from 3 medical centers were randomly assigned to treatment with daily low-dose sildenafil (25
Khaled M Hosny et al.
Expert opinion on drug delivery, 11(7), 1015-1022 (2014-04-22)
The aim of this study was to prepare sildenafil citrate as solid lipid nanoparticles (SLNs), in order to find an innovative way for alleviating the disadvantages associated with commercially available sildenafil citrate tablets. These limitations include poor solubility and extensive
Deanna Wung
International journal of pharmaceutical compounding, 17(1), 24-27 (2013-05-01)
The drugs tadalafil and sildenafil share the same mechanism. Although more research is necessary to solidify the recommendation of the routine use of tadalafil, human and dog data combined with pharmacokinetic data suggest that dogs may be safely treated for
Hunter C Champion
The American journal of cardiology, 111(8 Suppl), 21C-24C (2013-04-12)
Intravenous (IV) prostacyclin (epoprostanol) and its analogs (iloprost and treprostinil) are effective in treating pulmonary artery hypertension (PAH). Although prostacyclins are available for inhaled and subcutaneous delivery, IV administration of prostacyclins, sometimes in combination with other agents, such as bosentan
[Yesterday, Viagra was a drug (2) ].
Jean-Yves Nau
Revue medicale suisse, 9(393), 1446-1447 (2013-08-27)
Hamid Mahdiuni et al.
Biophysical chemistry, 175-176, 1-16 (2013-03-19)
Sildenafil was investigated for its interaction with the native and modified human carbonic anhydrase II (hCA II). Modification of exposed histidine side chains with diethyl pyrocarbonate decreased esterase activity of the enzyme. The treatment of both native and modified CA
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