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Circulating ribonucleic acids and metabolic stress parameters may reflect progression of autoimmune or inflammatory conditions in juvenile type 1 diabetes.
Kocic G
TheScientificWorldJournal, 11, 1496-1508 (2011)
Arash Kianianmomeni et al.
Plant physiology, 151(1), 347-366 (2009-07-31)
Channelrhodopsins are light-gated ion channels involved in the photoresponses of microalgae. Here, we describe the characterization of two channelrhodopsins, Volvox channelrhodopsin-1 (VChR1) and VChR2, from the multicellular green alga Volvox carteri. Both are encoded by nuclear single copy genes and
J B Buchanan et al.
Psychoneuroendocrinology, 33(6), 755-765 (2008-04-15)
Peripheral immune stimulation as well as certain types of psychological stress increases brain levels of inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNFalpha). We have demonstrated that aged mice show greater increases in central inflammatory
Hyo-Jin Jeong et al.
Molecular pain, 4, 54-54 (2008-11-19)
There is evidence to suggest that the midbrain periaqueductal grey (PAG) has a role in migraine and the actions of the anti-migraine drug sumatriptan. In the present study we examined the serotonergic modulation of GABAergic and glutamatergic synaptic transmission in
Byungki Jang et al.
The American journal of pathology, 173(4), 1129-1142 (2008-09-13)
Peptidylarginine deiminases (PADs), which are a group of posttranslational modification enzymes, are involved in protein citrullination (deimination) by the conversion of peptidylarginine to peptidylcitrulline in a calcium concentration-dependent manner. Among the PADs, PAD2 is widely distributed in various tissues and
Dan Wang et al.
Molecular genetics and metabolism, 99(1), 62-71 (2009-09-16)
Here we report the characterization of a knock-in mouse model for the autosomal recessive disorder mucopolysaccharidosis type I-Hurler (MPS I-H), also known as Hurler syndrome. MPS I-H is the most severe form of alpha-l-iduronidase deficiency. alpha-l-iduronidase (encoded by the IDUA
Ignacio Gonzalez-Suarez et al.
The EMBO journal, 28(16), 2414-2427 (2009-07-25)
A-type lamins are intermediate filament proteins that provide a scaffold for protein complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked to a variety of degenerative disorders termed laminopathies, whereas changes in the expression of lamins
Anna Marie Price et al.
Plant physiology, 147(4), 1898-1912 (2008-06-10)
Petals and leaves share common evolutionary origins but perform very different functions. However, few studies have compared leaf and petal senescence within the same species. Wallflower (Erysimum linifolium), an ornamental species closely related to Arabidopsis (Arabidopsis thaliana), provide a good
Gavin S Wilkie et al.
Molecular & cellular proteomics : MCP, 10(1), M110-M110 (2010-09-30)
Nuclear envelopes from liver and a neuroblastoma cell line have previously been analyzed by proteomics; however, most diseases associated with the nuclear envelope affect muscle. To determine whether muscle has unique nuclear envelope proteins, rat skeletal muscle nuclear envelopes were
Purification of RNA using TRIzol (TRI reagent)
Rio D, et al.
Cold Spring Harbor Protocols, 2010(6), pdb-prot5439 (2010)
Tadeja Rezen et al.
BMC genomics, 10, 384-384 (2009-08-21)
Detoxification in the liver involves activation of nuclear receptors, such as the constitutive androstane receptor (CAR), which regulate downstream genes of xenobiotic metabolism. Frequently, the metabolism of endobiotics is also modulated, resulting in potentially harmful effects. We therefore used 1,4-Bis
Ana M Martín-Hernández et al.
Journal of virology, 82(8), 4064-4071 (2008-02-15)
RNA silencing is a host defense mechanism that limits the accumulation and spread of viruses in infected plants. Correspondingly, plant viruses encode suppressors of silencing. In the positive-strand RNA virus Tobacco rattle virus (TRV), the suppressor of silencing is a
Yael Friedman-Levi et al.
PLoS pathogens, 7(11), e1002350-e1002350 (2011-11-11)
Genetic prion diseases are late onset fatal neurodegenerative disorders linked to pathogenic mutations in the prion protein-encoding gene, PRNP. The most prevalent of these is the substitution of Glutamate for Lysine at codon 200 (E200K), causing genetic Creutzfeldt-Jakob disease (gCJD)
Maria Oczkowicz et al.
Genetics and molecular biology, 33(4), 790-794 (2011-06-04)
The Drosophila-like homolog 1 (DLK1), a transmembrane signal protein similar to other members of the Notch/Delta/Serrate family, regulates the differentiation process in many types of mammalian cells. Callipyge sheep and DLK1 knockout mice are excellent examples of a fundamental role
Chitvan Khajuria et al.
BMC genomics, 10, 286-286 (2009-06-30)
Lepidoptera represents more than 160,000 insect species which include some of the most devastating pests of crops, forests, and stored products. However, the genomic information on lepidopteran insects is very limited. Only a few studies have focused on developing expressed
Heiner Kuhl et al.
Molecular biology and evolution, 38(1), 108-127 (2020-08-12)
Presumably, due to a rapid early diversification, major parts of the higher-level phylogeny of birds are still resolved controversially in different analyses or are considered unresolvable. To address this problem, we produced an avian tree of life, which includes molecular
María Muñoz et al.
Genetics, selection, evolution : GSE, 42, 23-23 (2010-06-26)
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Moreover, we investigated a possible effect of the interaction
Juliana L de Oliveira et al.
Lipids in health and disease, 10, 22-22 (2011-01-27)
Although lipids transfer through placenta is very limited, modification in dietary fatty acids can lead to implications in fetal and postnatal development. Trans fatty acid (TFA) intake during gestation and lactation have been reported to promote dyslipidemia and increase in
A novel CLCN5 mutation in a Chinese boy with Dent's disease.
Ji LN
World Journal of Pediatrics : WJP, 10(3), 275-277 (2014)
Joanna B Strosznajder et al.
Neurochemical research, 36(5), 839-848 (2011-02-03)
The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor
P Gómez et al.
Journal of virology, 83(23), 12378-12387 (2009-09-18)
Pepino mosaic virus (PepMV) is an emerging pathogen that causes severe economic losses in tomato crops (Solanum lycopersicum L.) in the Northern hemisphere, despite persistent attempts of control. In fact, it is considered one of the most significant viral diseases
Hyun-Ju Hwang et al.
Journal of experimental botany, 62(13), 4571-4581 (2011-06-01)
In Arabidopsis, inflorescence stem formation is a critical process in phase transition from the vegetative to the reproductive state. Although inflorescence stem development has been reported to depend on the expression of a variety of genes during floral induction and
Gandhi N Solayar et al.
BMC musculoskeletal disorders, 12, 247-247 (2011-11-01)
Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs). A number of studies have suggested that long term administration of these drugs may adversely affect osteoblasts and therefore, bone metabolism. Xarelto™ (Rivaroxaban) is a new
Munir Boodhwani et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 33(4), 645-650 (2008-01-19)
Growth factor based angiogenesis, with or without cell therapy, is a promising therapeutic modality for patients with coronary artery disease. We compared the relative efficacies of surgically delivered vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) in a
Penny E Reid et al.
Molecular cancer, 8, 49-49 (2009-07-17)
Angiogenesis, the sprouting of capillaries from existing blood vessels, is central to tumour growth and progression, however the molecular regulation of this process remains to be fully elucidated. The secreted glycoprotein osteoprotegerin (OPG) is one potential pro-angiogenic factor, and clinical
Blanca M Herrera et al.
BMC medical genomics, 2, 54-54 (2009-08-20)
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action
Bradley P Dixon et al.
PloS one, 6(1), e16595-e16595 (2011-02-10)
Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly increased risk of malignancy, and the bladder microenvironment may play a role in this carcinogenesis. Investigating the influences of the bladder microenvironment
A B Abera et al.
Cellular signalling, 22(1), 71-79 (2009-09-29)
Prostaglandins exert their effects on target cells by coupling to specific G protein-coupled receptors (GPCRs) that are often co-expressed in the same cells and use alternate and in some cases opposing intracellular signaling pathways. This study investigated the cross-talk that
Carolyn Riddell et al.
PloS one, 4(10), e7621-e7621 (2009-10-28)
Recent ecological studies in invertebrates show that the outcome of an infection is dependent on the specific pairing of host and parasite. Such specificity contrasts the long-held view that invertebrate innate immunity depends on a broad-spectrum recognition system. An important
Ondrej Krinke et al.
Plant physiology, 150(1), 424-436 (2009-03-24)
Salicylic acid (SA) plays a central role in defense against pathogen attack, as well as in germination, flowering, senescence, and the acquisition of thermotolerance. In this report we investigate the involvement of phospholipase D (PLD) in the SA signaling pathway.
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