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Narayanan K Narayanan et al.
Cancer medicine, 4(11), 1767-1780 (2015-09-27)
Melinjo (Gnetum gnemon L.) seed extract (MSE) and its active ingredient gnetin C (GC), a resveratrol dimer, have been shown to possess a broad spectrum of pharmacological activities. In this study, we investigated the antitumor activity of MSE and GC
Afaf Sahraoui et al.
Cell transplantation, 23(10), 1199-1211 (2013-05-03)
Pretreatment culture before islet transplantation represents a window of opportunity to ameliorate the proinflammatory profile expressed by human β-cells in duress. Anakinra (IL-1 receptor antagonist) and tocilizumab (monoclonal IL-6 receptor antibody) are two known anti-inflammatory agents successfully used in the
Lawrence Mok et al.
The Journal of general virology, 96(Pt 7), 1787-1794 (2015-03-10)
In recent years, bats have been identified as a natural reservoir for a diverse range of viruses. Nelson Bay orthoreovirus (NBV) was first isolated from the heart blood of a fruit bat (Pteropus poliocephalus) in 1968. While the pathogenesis of
Jonathan Hewitt et al.
The Cochrane database of systematic reviews, 6(6), CD009204-CD009204 (2012-06-15)
Acute kidney injury (AKI) is a common, serious, but potentially treatable condition. Because AKI is often associated with acidosis, it has become common practice to recommend administration of sodium bicarbonate to correct acid imbalance. To assess the benefits and harms
Sandra Milena Bernal Ulloa et al.
Zygote (Cambridge, England), 23(3), 367-377 (2014-01-16)
Cyclic adenosine monophosphate (cAMP) modulators have been used to avoid spontaneous oocyte maturation and concomitantly improve oocyte developmental competence. The current work evaluated the effects of the addition of cAMP modulators forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cilostamide during in vitro maturation
Marilis Rodriguez et al.
PloS one, 9(9), e107727-e107727 (2014-09-17)
Human babesiosis is caused by one of several babesial species transmitted by ixodid ticks that have distinct geographical distributions based on the presence of competent animal hosts. The pathology of babesiosis, like malaria, is a consequence of the parasitaemia which
Krishna Gokul et al.
Neurochemical research, 39(7), 1382-1394 (2014-05-17)
Although tomato seeds (an industrial by-product) are known to contain several bioactive compounds, studies describing their health effects are limited. Previously, we evidenced that aqueous extract of tomato seeds (TSE) markedly attenuated rotenone (ROT)-induced oxidative stress and neurotoxicity in Drosophila
Jessey Erath et al.
Antimicrobial agents and chemotherapy, 59(3), 1427-1434 (2014-12-17)
Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against Plasmodium asexual blood stages to be developed for treatment. In addition, the current malaria eradication programs require the development of drugs
Prasuna Paluru et al.
Stem cell research, 12(2), 441-451 (2014-01-15)
The Wnt gene family consists of structurally related genes encoding secreted signaling molecules that have been implicated in many developmental processes, including regulation of cell fate and patterning during embryogenesis. Previously, we found that Wnt signaling is required for primitive
Ling-yun Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(41), 13670-13683 (2014-10-10)
Sensory information undergoes ordered and coordinated processing across cortical layers. Whereas cortical layer (L) 4 faithfully acquires thalamic information, the superficial layers appear well staged for more refined processing of L4-relayed signals to generate corticocortical outputs. However, the specific role
Elena Berezhnaya et al.
Journal of biomedical optics, 20(7), 75004-75004 (2015-07-15)
Photodynamic therapy (PDT) is currently used in the treatment of brain tumors. However, not only malignant cells but also neighboring normal neurons and glial cells are damaged during PDT. In order to study the potential role of transcription factors-nuclear factor
Vanessa Neuhaus et al.
Vaccine, 32(26), 3216-3222 (2014-04-16)
Annually influenza virus infections are responsible for hospitalization and mortality, especially in high risk groups. Constant antigenic changes in seasonal influenza viruses resulted from antigenic shifts and antigenic drifts, enable emerging of novel virus subtypes that may reduce current vaccine
Effect of oral care solutions in reducing ventilator-associated pneumonia: review of current evidence.
E Balamurugan et al.
The Nursing journal of India, 103(6), 282-284 (2013-08-09)
Nrupa Borkar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 216-223 (2014-12-17)
Apomorphine, a subcutaneously administered drug for Parkinson's disease with short half-life requires frequent administration leading to patient non-compliance. This study aimed at synthesising and purifying lipophilic diesters of apomorphine, and investigating their in vitro degradation in biorelevant media before and
Toru Taguchi et al.
Pain, 156(3), 415-427 (2015-01-20)
Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood. Using a reserpine-induced pain model originally reported as a putative animal model for fibromyalgia, this study was undertaken to examine the following:
Investigating the antifungal activity and mechanism(s) of geraniol against Candida albicans strains.
Maria Clerya Alvino Leite et al.
Medical mycology, 53(3), 275-284 (2014-12-07)
Candida albicans can be a yeast that is a commensal on the human body but can cause opportunistic or pathogenic infections. Candida infections may create serious health problems and as a result has initiated a search for new drugs with
Arin Marchesi et al.
The Journal of physiology, 593(4), 857-870 (2014-12-07)
Desensitization and inactivation provide a form of short-term memory controlling the firing patterns of excitable cells and adaptation in sensory systems. Unlike many of their cousin K(+) channels, cyclic nucleotide-gated (CNG) channels are thought not to desensitize or inactivate. Here
Stefan Schöneich et al.
Journal of neurophysiology, 113(1), 390-399 (2014-10-17)
Crickets carry wind-sensitive mechanoreceptors on their cerci, which, in response to the airflow produced by approaching predators, triggers escape reactions via ascending giant interneurons (GIs). Males also activate their cercal system by air currents generated due to the wing movements
Gurunath Surampalli et al.
Drug development and industrial pharmacy, 41(7), 1057-1065 (2014-06-12)
The aim of this study was to corroborate the effects of naringin, a P-glycoprotein inhibitor, on the intestinal absorption and pharmacokinetics of candesartan (CDS) from candesartan cilexetil (CAN) solid dispersions using in-situ rat models. Intestinal transport and absorption studies were
J Do Valle Bargieri et al.
The Journal of sports medicine and physical fitness, 53(5), 470-476 (2013-08-02)
Decrease in peripheral oxygen delivery may impact exercise performance in athletes with exercise-related arterial oxygen desaturation (ERD). We evaluated whether sodium bicarbonate ingestion would be effective to reduce ERD and what is the consequences upon exercise performance. Seventy highly trained
Kai Flachsbarth et al.
Investigative ophthalmology & visual science, 55(11), 7029-7039 (2014-10-02)
To analyze the neuroprotective effect of intravitreally grafted neural stem (NS) cells genetically modified to secrete ciliary neurotrophic factor (CNTF) on intraorbitally lesioned retinal ganglion cells (RGCs) in adult mice. Adherently cultivated NS cells were genetically modified to express a
Li Li et al.
International journal of pharmaceutics, 471(1-2), 339-348 (2014-06-19)
Poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL) micelles dually loaded with both pheophorbide a (PhA) as a photosensitizer and β-carotene (CAR) as a singlet oxygen ((1)O2) scavenger were designed to control photodynamic therapy (PDT) activity in cancer treatment. The CAR in the PhA/CAR micelles
Aditya Stanam et al.
Molecular oncology, 9(7), 1371-1383 (2015-04-19)
Despite the role of epidermal growth factor receptor (EGFR) signaling in head and neck squamous cell carcinoma (HNSCC) development and progression, clinical trials involving EGFR tyrosine kinase inhibitors (TKIs) have yielded poor results in HNSCC patients. Mechanisms of acquired resistance
Feng An et al.
PloS one, 10(4), e0125595-e0125595 (2015-05-01)
Rubber tree (Hevea brasiliensis) latex, the source of natural rubber, is synthesised in the cytoplasm of laticifers. Efficient water inflow into laticifers is crucial for latex flow and production since it is the determinant of the total solid content of
Qin-Hua Gu et al.
Nature communications, 6, 6789-6789 (2015-04-11)
Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. It is associated with the formation and enlargement of dendritic spines-tiny protrusions accommodating excitatory synapses. Both LTP and spine remodelling are crucial for brain development
Eugenio D Hottz et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1864-1872 (2014-07-13)
Dengue is the most prevalent human arbovirus disease in the world. Dengue infection has a large spectrum of clinical manifestations, from self-limited febrile illness to severe syndromes accompanied by bleeding and shock. Thrombocytopenia and vascular leak with altered cytokine profiles
Claire O Malécot et al.
Journal of cardiovascular electrophysiology, 26(3), 311-319 (2014-10-28)
Ectopic activity arising from pulmonary veins (PV) plays a prominent role in the onset of atrial fibrillation in humans. Rat PV cardiac muscle cells have a lower resting membrane potential (RMP) than the left atria (LA) and presents in the
Sullim Lee et al.
Natural product communications, 10(7), 1153-1158 (2015-09-29)
In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the 70% EtOH extract of the crude drug Andrographis Herba (aerial parts of Andrographis paniculata), used in Japanese Kampo medicines, killed PANC-1
Katrijn De Brucker et al.
Antimicrobial agents and chemotherapy, 58(9), 5395-5404 (2014-07-02)
We identified a 26-amino-acid truncated form of the 34-amino-acid cathelicidin-related antimicrobial peptide (CRAMP) in the islets of Langerhans of the murine pancreas. This peptide, P318, shares 67% identity with the LL-37 human antimicrobial peptide. As LL-37 displays antimicrobial and antibiofilm
Biraja C Dash et al.
Biomaterials, 65, 126-139 (2015-07-08)
Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced inflammation are the two major pathophysiological
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