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V900415
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Nobuya Inagaki et al.
Journal of diabetes investigation, 6(2), 210-218 (2015-03-25)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor under development for the treatment of type 2 diabetes. Our aim was to examine its efficacy and safety as monotherapy or in combination with commonly used oral antihyperglycemic drugs in Japanese patients with
Procolo Di Bonito et al.
The Journal of pediatrics, 165(6), 1184-1189 (2014-09-23)
To investigate the anthropometric and metabolic correlates of different patterns of left ventricular (LV) geometry in a cohort of outpatient children with high prevalence of obesity. Anthropometric measures, lipid profile, blood pressure (BP), fasting plasma glucose (FPG), and echocardiographic variables
Tsong-Ming Lu et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 70(4), 395-400 (2015-09-20)
Onion (Allium cepa L.) is widely employed as a food ingredient as well as traditional remedy to treat fever, burns, and scurvy. The present study focused on the modulator efficacy of the quercetin rich onion juice on lipid profile and
Niloofar Moghadas-Sharif et al.
Drug development and industrial pharmacy, 41(3), 445-450 (2014-01-11)
The aim of the present study was to assess the in vitro antimicrobial activities of nanoliposomal formulations loaded with vancomycin or/and rifampin against the biofilm formed by Staphylococcus epidermidis at 37 °C under aerobic condition. Liposomal formulations were prepared by dehydration-rehydration
Caroline Damico Candido et al.
Journal of pharmaceutical sciences, 103(10), 3297-3301 (2014-08-08)
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich solid tumor (EST) and the heart
Yumin Wen et al.
BMC complementary and alternative medicine, 15, 155-155 (2015-05-28)
Yi Qi Qing Re Gao (YQQRG) formula is a traditional Chinese herbal medicine used to treat chronic nephritis. This study was designed to evaluate the underlying mechanism in the use of YQQRG formula to treat nephrosis induced by puromycin aminonucleoside
Paulo Cury Rezende et al.
Cardiovascular diabetology, 14, 66-66 (2015-05-31)
The influence of diabetes mellitus on myocardial ischemic preconditioning is not clearly defined. Experimental studies are conflicting and human studies are scarce and inconclusive. Identify whether diabetes mellitus intervenes on ischemic preconditioning in symptomatic coronary artery disease patients. Symptomatic multivessel
Shunsuke Kanno et al.
Journal of immunology (Baltimore, Md. : 1950), 194(2), 773-780 (2014-12-10)
Atherosclerosis is essentially a vascular inflammatory process in the presence of an excess amount of lipid. We have recently reported that oral administration of a nucleotide-binding oligomerization domain (Nod)-1 ligand, FK565, induced vascular inflammation in vivo. No studies, however, have
Xiaobo He et al.
Environmental research, 137, 458-466 (2015-02-14)
Electronic waste (e-waste) has created a worldwide environmental and health problem, by generating a diverse group of hazardous compounds such as persistent organic pollutants (POPs). Our previous studies demonstrated that populations from e-waste exposed region have a significantly higher level
Xiao-Ling Cai et al.
Chinese medical journal, 128(10), 1279-1287 (2015-05-13)
At present, China has listed the compound tablet containing a fixed dose of rosiglitazone and metformin, Avandamet, which may improve patient compliance. The aim of this study was to evaluate the efficacy and safety of Avandamet or uptitrated metformin treatment
Seiichiro Aoe et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1141-1146 (2015-04-03)
Konjac-mannan has been suggested to exert a protective effect against visceral obesity. However, there is little knowledge about the effects of liquid konjac (LK) that is partially alkali gelled. The purpose of the present work was to evaluate the potential
Edina Lump et al.
eLife, 4 (2015-08-19)
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we establish that CLR01, a 'molecular
Giorgio Sesti et al.
PloS one, 9(8), e104941-e104941 (2014-08-12)
Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage) is associated with more pronounced cardiovascular organ
Hanna Shevalye et al.
Journal of neurophysiology, 114(1), 199-208 (2015-05-01)
The purpose of this study was to determine the effect of supplementing the diet of a mouse model of type 2 diabetes with menhaden (fish) oil or daily treatment with resolvin D1 on diabetic neuropathy. The end points evaluated included
Rgia A Othman et al.
Atherosclerosis, 231(2), 291-299 (2013-11-26)
Sitosterolemia (STSL) is a rare autosomal recessive disease, manifested by extremely elevated plant sterols (PS) in plasma and tissue, leading to xanthoma and premature atherosclerotic disease. Therapeutic approaches include limiting PS intake, interrupting enterohepatic circulation of bile acid using bile
Gary Fraser et al.
Public health nutrition, 18(3), 537-545 (2014-03-19)
To compare cardiovascular risk factors between vegetarians and non-vegetarians in black individuals living in the USA. A cross-sectional analysis of a sub-set of 592 black women and men enrolled in the Adventist Health Study-2 (AHS-2) cohort of Seventh-day Adventists. Members
Jian Zhu et al.
American journal of therapeutics, 22(2), 141-146 (2013-07-13)
The chronic inflammatory processes and endothelial dysfunction play important roles in the development of diabetic nephropathy (DN); the study aims to evaluate the effect of thymosin β4 (Tβ4), which has apparent anti-inflammatory properties and is capable of improving endothelial dysfunction
Blood levels of antioxidants during age-related macular degeneration treatment by rheohaemapheresis.
Jana Aufartova et al.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 159(3), 400-406 (2015-06-17)
Rheohaemapheresis treatment influences rheological markers and most likely improves metabolism in affected retinal areas, resulting not only in absorption of soft drusen but also reduction or complete disappearance of drusenoid retinal pigment epithelium detachments. However, the character of the treatment
Constance Gayet-Boyer et al.
The British journal of nutrition, 112(12), 1914-1922 (2014-10-28)
The effects of ruminant (R) trans-fatty acids (TFA) on the risk of CVD are still under debate. It could be argued that the lack of the effect of R-TFA may be the result of the small amount of their intake.
Lili Ding et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 474-483 (2014-09-11)
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acids, and triglycerides. We investigated the effect of the specific SREBP suppressor andrographolide, a natural compound isolated from Andrographis paniculata
Jun Zhou et al.
Carbohydrate polymers, 121, 199-206 (2015-02-11)
The present study was designed to investigate the hypoglycemic activity and the potential mechanisms of Misgurnus anguillicaudatus polysaccharide (MAP) in streptozotocin-induced diabetic mice. MAP oral administration significantly decreased the blood levels of glucose, TC, TG, LDL-C, and increased the blood
Rozanne Kruger et al.
SpringerPlus, 4, 128-128 (2015-04-01)
Body mass index (BMI) (kg/m(2)) is used internationally to assess body mass or adiposity. However, BMI does not discriminate body fat content or distribution and may vary among ethnicities. Many women with normal BMI are considered healthy, but may have
Karina Fischer et al.
The American journal of clinical nutrition, 101(4), 794-807 (2015-04-04)
Visceral (VAT) and subcutaneous abdominal (SAAT) and trunk (STRAT) adipose tissue (AT) have been suggested to be differentially influenced by diet. We investigated whether and to what extent usual patterns of nutrient intake are associated with VAT, SAAT, and STRAT
Louise E See Hoe et al.
American journal of physiology. Heart and circulatory physiology, 307(6), H895-H903 (2014-07-27)
Cholesterol-rich caveolar microdomains and associated caveolins influence sarcolemmal ion channel and receptor function and protective stress signaling. However, the importance of membrane cholesterol content to cardiovascular function and myocardial responses to ischemia-reperfusion (I/R) and cardioprotective stimuli are unclear. We assessed
Shirley Gee Hoon Tang et al.
Journal of food science, 80(8), C1686-C1695 (2015-07-16)
A 16-wk feeding experiment was conducted to investigate the effects of a prebiotic, isomaltooligosaccharide (IMO), a probiotic, PrimaLac®, and their combination as a synbiotic on the chemical compositions of egg yolks and the egg quality of laying hens. One hundred
Philippe Andre et al.
American heart journal, 169(4), 587-593 (2015-03-31)
Laminopathies are associated with a broad spectrum of clinical manifestations, from lipodystrophy to cardiac diseases. The purpose of this study was to assess genotype-phenotype correlations in a lipodystrophic laminopathy caused by the Lamin A (LMNA) mutation T655fsX49. This mutation leads
Tenna Jørgensen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(6), 943-950 (2015-03-12)
It is well known that few weeks of high fat (HF) diet may induce metabolic disturbances and mitochondrial dysfunction in skeletal muscle. However, little is known about the effects of long-term HF exposure and effects on brain mitochondria are unknown.
M Elizabeth Wilcox et al.
JAMA, 311(23), 2422-2431 (2014-06-19)
Thoracentesis is performed to identify the cause of a pleural effusion. Although generally safe, thoracentesis may be complicated by transient hypoxemia, bleeding, patient discomfort, reexpansion pulmonary edema, and pneumothorax. To identify the best means for differentiating between transudative and exudative
Eung Ju Kim et al.
PloS one, 9(6), e97841-e97841 (2014-06-06)
Although triglyceride accumulation in the liver causes non-alcoholic fatty liver disease (NAFLD), hypercholesterolemia is also a main cause of NAFLD as well as atherosclerosis. However, NAFLD and atherosclerosis have not been investigated simultaneously in animal models fed a high-cholesterol diet.
S Maynard et al.
Acta physiologica (Oxford, England), 213(1), 156-170 (2014-04-08)
To examine associations of DNA damage, cardiovascular risk factors and physical performance with vitality, in middle-aged men. We also sought to elucidate underlying factors of physical performance by comparing physical performance parameters to DNA damage parameters and cardiovascular risk factors.
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