Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Journal of inorganic biochemistry (2011-11-22)

Joseph Lemire, Vasu D Appanna

PMID22099161

摘要

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

材料

Product Number

品牌

产品描述

266574

Sigma-Aldrich

铝, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis

326860

Sigma-Aldrich

铝, foil, thickness 0.13 mm, ≥99.99% trace metals basis

733369

Sigma-Aldrich

铝, foil, thickness 8 μm, 99% trace metals basis

326887

Sigma-Aldrich

铝, wire, diam. 0.58 mm, ≥99.99% trace metals basis

433705

Sigma-Aldrich

铝, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

GF29732496

铝, tube, 200mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF44675781

铝, rod, 1000mm, diameter 12.7mm, 99%

GF20784360

铝, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF94706354

铝, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF85240694

铝, honeycomb, 600x600mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm³, phenolic adhesive (resin), 99.5%

GF38294646

铝, mesh, 300x300mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF74087758

铝, wire reel, 1m, diameter 0.02mm, hard, 99.99%

GF98718935

铝, sphere, 100pcs, diameter 1.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF53821234

铝, mesh, 900x900mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF24569602

铝, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

GF02417677

铝, tube, 100mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%

GF26812043

铝, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm³, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%

GF51598761

铝, rod, 200mm, diameter 12.7mm, 99%

GF33055185

铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm³, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%

GF86118969

铝, honeycomb, 300x300mm, thickness 5mm, cell size 19mm, cell wall 0.064mm, core density 0.029g/cm³, phenolic adhesive (resin), 99.5%

GF04958084

铝, honeycomb, 300x300mm, thickness 5mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm³, phenolic adhesive (resin), 99.5%

GF86830566

铝, mesh, 600x600mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF64700524

铝, rod, 1000mm, diameter 5.0mm, as drawn, 99.999%

GF12712610

铝, sphere, 100pcs, diameter 6.0mm, 99%

GF37306267

铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm³, porosity 0.93, 2 pores/cm, aluminum 6101 grade, 98.5%

GF54273944

铝, tube, 500mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%

GF07499010

铝, foam, 150x150mm, thickness 10mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

GF32029444

铝, rod, 100mm, diameter 12.7mm, 99%

GF28125390

铝, tube, 200mm, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, as drawn, 99.5%

GF10029596

铝, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm³, porosity 0.93, 8 pores/cm, aluminum 6101 grade, 98.5%