跳转至内容

CN

Iodocyclization, followed by palladium-catalyzed coupling: a versatile strategy for heterocyclic library construction.

Iodocyclization, followed by palladium-catalyzed coupling: a versatile strategy for heterocyclic library construction.

Combinatorial chemistry & high throughput screening (2012-01-26)

Anton V Dubrovskiy, Nataliya A Markina, Richard C Larock

摘要

The iodocyclization of functionally-substituted alkynes provides an excellent way to prepare a wide range of iodoheterocycles, which can then be readily elaborated through palladium-catalyzed Suzuki-Miyaura, Sonogashira, Heck, Hartwig-Buchwald, and carbonylation processes into libraries of medicinally relevant heterocycles. The synthesis of libraries of indoles, benzofurans, benzothiophenes, isocoumarins and pyrones, cyclic imidates, isoxazoles, furans using this approach is reviewed. This technology is very versatile, proceeds under mild reaction conditions in high yields, and tolerates considerable functionality.

材料

Product Number

品牌

产品描述

Sigma-Aldrich

钯, powder, 99.995% trace metals basis

Sigma-Aldrich

钯, powder, <1 μm, ≥99.9% trace metals basis

Sigma-Aldrich

钯, nanopowder, <25 nm particle size (TEM), ≥99.5%

Sigma-Aldrich

钯, powder or granules, 99.99% trace metals basis

Sigma-Aldrich

钯, foil, thickness 0.025 mm, 99.9% trace metals basis

钯, rod, 100mm, diameter 2.0mm, 99.95%

Sigma-Aldrich

钯, sponge, 99.9% trace metals basis

Sigma-Aldrich

钯, powder, <75 μm, 99.9% trace metals basis

钯, wire reel, 1m, diameter 0.25mm, as drawn, 99.99+%

Sigma-Aldrich

钯, wire, diam. 0.5 mm, 99.9% trace metals basis

钯, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%

Sigma-Aldrich

钯, wire, diam. 1.0 mm, 99.9% trace metals basis

Sigma-Aldrich

钯, foil, thickness 0.5 mm, 99.9% trace metals basis

Sigma-Aldrich

钯, foil, thickness 1.0 mm, 99.9% trace metals basis

Sigma-Aldrich

钯, foil, thickness 0.25 mm, 99.98% trace metals basis

钯, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

钯, rod, 50mm, diameter 4.0mm, 99.95%

Sigma-Aldrich

钯, evaporation slug, diam. × L 0.6 cm × 0.6 cm, 99.95% trace metals basis

钯, wire reel, 0.2m, diameter 0.25mm, as drawn, 99.99+%

钯, rod, 25mm, diameter 4.0mm, 99.95%

钯, rod, 50mm, diameter 2.0mm, 99.95%

钯, tube, 120mm, outside diameter 6mm, inside diameter 5mm, wall thickness 0.5mm, as drawn, 99.95%

钯, wire reel, 1m, diameter 0.05mm, as drawn, 99.9%

钯, rod, 10mm, diameter 6.0mm, 99.95%

钯, rod, 25mm, diameter 6.0mm, 99.95%

钯, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

钯, foil, light tested, 25x25mm, thickness 0.075mm, as rolled, 99.95%

钯, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%

钯, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%

钯, foil, 8mm disks, thickness 0.02mm, as rolled, 99.95%