M8819
Mannide monooleate
from plant
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About This Item
CAS Number:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
Form:
liquid
Quality level:
InChI
1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1
SMILES string
CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O
InChI key
NWGKJDSIEKMTRX-AAZCQSIUSA-N
biological source
plant
form
liquid
color
dark brown
storage temp.
room temp
Quality Level
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Application
Mannide monooleate has been used in a study to assess Freund′s incomplete adjuvant emulsion system, which is used in vaccine therapy. It has also been used in a study to investigate the metabolic fate of mineral oil adjuvants using 14C-labeled tracers.
Biochem/physiol Actions
Mannide monooleate is an emulsifying agent utilized in Freund′s incomplete adjuvant, although reactogenicity is an issue with human use.
General description
Mannide monooleate is a lipohilic surfactant. It is also a non-ionic surface active emulsifier.
Other Notes
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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R O Williams et al.
Drug development and industrial pharmacy, 24(2), 157-162 (2004-12-21)
Freund's Incomplete Adjuvant (FIA), which is used in vaccine therapy, is a water-in-oil emulsion delivery system consisting of an aqueous internal phase containing an antigenic protein dispersed in an external phase containing a mixture of mannide monooleate and light mineral
Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. II. Mannide monooleate.
J N Bollinger
Journal of pharmaceutical sciences, 59(8), 1088-1092 (1970-08-01)
James S McCarthy et al.
PloS one, 6(9), e24413-e24413 (2011-09-29)
In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children were reduced by 62%. However, breakthrough parasitemias were disproportionately of the alternate dimorphic form
Meta Roestenberg et al.
PloS one, 3(12), e3960-e3960 (2008-12-19)
Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies. We assessed the safety and
Mark A Pierce et al.
Vaccine, 28(10), 2236-2242 (2010-01-07)
A Phase 1 trial was conducted in malaria-naïve adults to evaluate the recombinant protein vaccine apical membrane antigen 1-Combination 1 (AMA1-C1) formulated in Montanide ISA 720 (SEPPIC, France), a water-in-oil adjuvant. Vaccinations were halted early due to a formulation issue
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