Merck
CN

ADRA2B

adrenoceptor alpha 2B

别名:
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR
物种:
UniProtKB ID:
基因ID:
  • Human(151) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]
  • Mouse(11552) adrenergic receptor, alpha 2b
  • Rat(24174) adrenoceptor alpha 2B
  • cow(516422) adrenergic, alpha-2B-, receptor
  • naked mole-rat(101701692) adrenoceptor alpha 2B
  • chicken(427631) adrenergic, alpha-2B-, receptor
  • domestic cat(101090432) adrenoceptor alpha 2B
  • domestic guinea pig(100135476) adrenergic receptor, alpha 2b
  • Zebrafish(266751) adrenergic, alpha-2B-, receptor
  • domestic guinea pig(100727868) adrenoceptor alpha 2B
  • dog(611658) adrenergic, alpha-2B-, receptor
  • Horse(100051684) adrenoceptor alpha 2B
  • sheep(100170318) adrenoceptor alpha 2B

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Small Molecule - Agonist

货号
说明
物种
可乐定 盐酸盐, solid,
物种
human
甲苯噻嗪 盐酸盐, ≥99.0% (HPLC),
物种
human
胍那苄 乙酸盐, powder,
物种
human
(-)-3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸 倍半水合物, 99%,
物种
human
Guanfacine hydrochloride, ≥98% (HPLC),
物种
human

Small Molecule - Antagonist

货号
说明
物种
Idazoxan hydrochloride, ,
物种
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
物种
human
UK 14,304, ,
物种
human
米氮平, British Pharmacopoeia (BP) Reference Standard,
物种
human
米氮平 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-Alpha 2b Adrenergic Receptor, from rabbit, purified by affinity chromatography,
物种反应性
human
应用
immunohistochemistry
western blot
Anti-ADRA2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-ADRA2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence

Small Molecule - Blocker

货号
说明
物种
胍丁胺 硫酸盐, ≥97%, powder,
物种
human

Small Molecule - Mixed Agonist/Antagonist

货号
说明
物种
UK 14,304, ,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human ADRA2B,
物种
human