Merck
CN

BRCA1

breast cancer 1, early onset

别名:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
物种:
UniProtKB ID:
基因ID:
  • Human(672) Summary: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
  • Mouse(12189) breast cancer 1
  • Rat(497672) breast cancer 1, early onset
  • domestic cat(101081937) breast cancer 1, early onset
  • domestic guinea pig(100722339) breast cancer 1, early onset
  • naked mole-rat(101705460) breast cancer 1, early onset
  • sheep(101108584) breast cancer 1, early onset
  • Domestic Rabbit(100347269) breast cancer 1, early onset
  • cow(353120) breast cancer 1, early onset
  • domestic cat(493761) breast cancer 1, early onset
  • Horse(100051990) breast cancer 1, early onset
  • dog(403437) breast cancer 1, early onset
  • chicken(373983) breast cancer 1, early onset
  • Thale Cress(827854) protein BREAST CANCER SUSCEPTIBILITY 1-like protein

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Antibodies

货号
说明
物种反应性
应用
抗-BRCA1(Ab-1)小鼠mAb(MS110), liquid, clone MS110, Calbiochem®,
物种反应性
human
应用
Monoclonal Anti-BRCA1 antibody produced in mouse, ,
物种反应性
human, mouse
应用
ChIP
immunocytochemistry

immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Monoclonal Anti-BRCA1 antibody produced in mouse, ,
物种反应性
human, mouse
应用
ChIP
ELISA

immunocytochemistry

immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
抗-BRCA1抗体,克隆MS13, clone MS13, from mouse,
物种反应性
human
应用
immunocytochemistry
immunohistochemistry

western blot
Anti-BRCA1 (Ab-4) Mouse mAb (SD118), liquid, clone SD118, Calbiochem®,
物种反应性
human
应用

Kits

货号
说明
物种
CpG WIZ BRCA1 -Methylation specific PCR assay, Methylation-specific PCR (MSP), performed using the CpGenome DNA Modification Kit & the CpG WIZ BRCA1 Amplification Kit, permits sensitive detection of altered DNA.,
物种
human

Proteins

货号
说明
物种
PrEST Antigen BRCA1, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Brca1,
物种
mouse
MISSION® esiRNA, targeting human BRCA1,
物种
human