Merck
CN

ERBB3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

别名:
ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
物种:
UniProtKB ID:
基因ID:
  • Human(2065) Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13867) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Rat(29496) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
  • cow(785655) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • dog(481105) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • domestic guinea pig(100712946) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • chicken(693245) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
  • sheep(101103889) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Domestic Rabbit(100008807) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Horse(100059216) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • domestic cat(101085388) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • naked mole-rat(101721671) v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

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ELISA

货号
说明
物种
磷酸酪氨酸ERBB3 /受体酪氨酸蛋白激酶erbB-3 ELISA试剂盒, ,
物种
human
人ErbB3 / HER3 ELISA试剂盒, for serum, plasma, cell culture supernatant and urine,
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-erbB-3/HER-3 Antibody, clone 2F12, clone 2F12, Upstate®, from mouse,
物种反应性
bovine, human, mouse, rat
应用
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-ERBB3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
Anti-ERBB3/HER3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
canine, human, mouse, rat
应用
ELISA
western blot
Anti-phospho-HER3 (pTyr1197) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
抗-ERBB3 (Ab-1328) 兔抗, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot

Proteins

货号
说明
物种
ErbB3/HER3 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human ERBB3,
物种
human
MISSION® esiRNA, targeting mouse Erbb3,
物种
mouse