Merck
CN

HDAC8

histone deacetylase 8

别名:
CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
物种:
Human HDAC8 (55869), Mouse Hdac8 (70315), Rat Hdac8 (363481), domestic guinea pig Hdac8 (100721893), chicken HDAC8 (422182), Zebrafish hdac8 (406740), domestic cat HDAC8 (101096383), dog HDAC8 (480957), sheep HDAC8 (101110121), cow HDAC8 (540666)
UniProtKB ID:
Q9BY41, A6ND12, A6ND61, A6NET3, A6NJR3, A8MQ62, B4DKN0, B4DV22
基因ID:
  • Human(55869) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(70315) histone deacetylase 8
  • Rat(363481) histone deacetylase 8
  • domestic guinea pig(100721893) histone deacetylase 8
  • chicken(422182) histone deacetylase 8
  • Zebrafish(406740) histone deacetylase 8
  • domestic cat(101096383) histone deacetylase 8
  • dog(480957) histone deacetylase 8
  • sheep(101110121) histone deacetylase 8
  • cow(540666) histone deacetylase 8
  • naked mole-rat(101697998) histone deacetylase 8

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Antibodies

货号
说明
物种反应性
应用
07-505
Anti-HDAC8 Antibody, serum, Upstate®,
物种反应性
human, mouse
应用
immunoprecipitation (IP)
western blot
HPA048560
Anti-HDAC8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
SAB5700224
Anti-HDAC8 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
western blot
WH0055869M1
Monoclonal Anti-HDAC8 antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
western blot
SAB5702655
[KO Validated]Anti-HDAC8 Antibody, clone 1O2Y5, Rabbit Monoclonal, ,
物种反应性
human, rat
应用
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

货号
说明
物种
SML1175
罗咪酯肽, ≥98% (HPLC),
物种
human
C0621
CI−994, ≥98% (HPLC), powder,
物种
human

Kits

货号
说明
物种
EPI007
组蛋白脱乙酰基酶8（HDAC8）抑制剂筛选试剂盒, 100 assays in 96 well plates,
物种
human, mouse

Proteins

货号
说明
物种
SRP0110
HDAC-8 human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
EHU088741
MISSION® esiRNA, targeting human HDAC8,
物种
human
EMU176251
MISSION® esiRNA, targeting mouse Hdac8,
物种
mouse