Merck
CN

KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

别名:
KIR1.1, ROMK, ROMK1
物种:
UniProtKB ID:
基因ID:
  • Human(3758) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56379) potassium inwardly-rectifying channel, subfamily J, member 1
  • Rat(24521) potassium inwardly-rectifying channel, subfamily J, member 1
  • chicken(428236) potassium inwardly-rectifying channel, subfamily J, member 1
  • Horse(100072580) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic cat(101091140) potassium inwardly-rectifying channel, subfamily J, member 1
  • cow(539250) potassium inwardly-rectifying channel, subfamily J, member 1
  • dog(489285) potassium inwardly-rectifying channel, subfamily J, member 1
  • naked mole-rat(101720253) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic guinea pig(100722828) potassium inwardly-rectifying channel, subfamily J, member 1

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Small Molecule - Activator

货号
说明
物种
二氮嗪, ,
物种
rat, mouse, human

Small Molecule - Antagonist

货号
说明
物种
Cromakalim, ,
物种
rat
格列本脲, meets USP testing specifications,
物种
rat, human
格列本脲, ≥99% (HPLC),
物种
rat, human
氯磺丙脲, analytical standard, ≥97%,
物种
human, mouse
甲苯磺丁脲, analytical standard,
物种
human, mouse

Antibodies

货号
说明
物种反应性
应用
Anti-KCNJ1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
western blot
Anti-KCNJ1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-ROMK antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
Anti-KCNJ1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
dog, guinea pig, horse, human, rabbit, rat
应用
western blot

Small Molecule - Blocker

货号
说明
物种
格列齐特, powder, ≥98%,
物种
human
格列美脲, ≥98% (HPLC), solid,
物种
human
格列吡嗪, solid,
物种
human
瑞格列奈, ≥98% (HPLC), solid,
物种
human
格列本脲, meets USP testing specifications,
物种
rat, human

Small Molecule - Inhibitor

货号
说明
物种
VU591, ≥98% (HPLC),
物种
human
Tertiapin-Q trifluoroacetate salt, ≥97% (HPLC),
物种
rat, human, mouse
氯磺丙脲, analytical standard, ≥97%,
物种
human, mouse
甲苯磺丁脲, analytical standard,
物种
human, mouse
吡那地尔 一水合物, powder,
物种
mouse, rat, human

Small Molecule - Ligand

货号
说明
物种
格列美脲, ≥98% (HPLC), solid,
物种
human
格列吡嗪, solid,
物种
human
格列本脲, ≥99% (HPLC),
物种
rat, human
氯磺丙脲, analytical standard, ≥97%,
物种
human, mouse

Small Molecule - Opener

货号
说明
物种
米诺地尔, ≥99% (TLC),
物种
human
吡那地尔 一水合物, powder,
物种
mouse, rat, human
二氮嗪, ,
物种
rat, mouse, human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human KCNJ1,
物种
human