Merck
CN

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

别名:
EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
物种:
UniProtKB ID:
基因ID:
  • Human(4790) Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Mouse(18033) nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
  • Rat(81736) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • naked mole-rat(101696485) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • sheep(101108228) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • cow(616115) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • dog(442859) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • domestic cat(100142683) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • Zebrafish(565756) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • chicken(396033) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • domestic guinea pig(100730075) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

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Small Molecule - Antagonist

货号
说明
物种
Z-Leu-Leu-Leu-al, ≥90% (HPLC),
物种
human
MG-132(R), ≥95% (HPLC),
物种
human
小白菊内酯, ≥98% (HPLC),
物种
human

Antibodies

货号
说明
物种反应性
应用
抗NF κ B抗体,p65亚基,活性亚基,克隆12H11, clone 12H11, Chemicon®, from mouse,
物种反应性
human, mouse, rabbit, rat
应用
electrophoretic mobility shift assay
flow cytometry

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
抗NF κ B p65抗体,CT, Upstate®, from rabbit,
物种反应性
human, mouse, rat
应用
electrophoretic mobility shift assay
immunoprecipitation (IP)

western blot
Anti-NF-kB p50/105 Antibody, clone 1N19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
immunocytochemistry
immunohistochemistry

western blot
抗-NFκB p50 抗体, from rabbit, purified by affinity chromatography,
物种反应性
human, rhesus macaque
应用
immunoprecipitation (IP)
western blot
Anti-phospho-NF-kB (p100) (Ser707) Antibody, from rabbit, purified by affinity chromatography,
物种反应性
human
应用
dot blot
inhibition assay

western blot

Small Molecule - Blocker

货号
说明
物种
Nα-甲苯磺酰基- L -赖氨酸氯甲基酮 盐酸盐, ≥96% (TLC), powder,
物种
human
N--甲苯磺酰基-L-苯基乙基氯甲基酮, ≥97% (TLC), powder,
物种
human

Small Molecule - Inhibitor

货号
说明
物种
Bay 11-7085, ≥98% (HPLC), solid,
物种
human
Z-Leu-Leu-Leu-al, ≥90% (HPLC),
物种
human
MG-132(R), ≥95% (HPLC),
物种
human
小白菊内酯, ≥98% (HPLC),
物种
human
大黄素, from Frangula bark, ≥90% (HPLC),
物种
human

Proteins

货号
说明
物种
GST-NFκB p50 subunit (δ434-969), N-terminal GST-tagged, recombinant human NFkB, p50 subunit (D434-969), expressed in E. coli. Purified using glutathione agarose chromatography.,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human NFKB1,
物种
human
MISSION® esiRNA, targeting mouse Nfkb1,
物种
mouse