Merck
CN

NOTCH1

notch 1

别名:
TAN1, hN1
物种:
UniProtKB ID:
基因ID:
  • Human(4851) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
  • Mouse(18128) notch 1
  • Rat(25496) notch 1
  • cow(767866) notch 1
  • chicken(395655) notch 1
  • dog(480676) notch 1
  • sheep(101115020) notch 1
  • naked mole-rat(101704336) notch 1
  • domestic cat(101094384) notch 1
  • Horse(100068764) notch 1
  • domestic guinea pig(100724583) notch 1

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ELISA

货号
说明
物种
大鼠Notch-1 ELISA, for serum, plasma and cell culture supernatants,
物种
rat
人 Notch-1 ELISA 试剂盒, for serum, plasma, cell culture supernatants and urine,
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-Notch1 Antibody, clone 7L3V4, Rabbit Monoclonal, ,
物种反应性
mouse
应用
immunoprecipitation (IP)
western blot
Anti-Notch 1 Antibody, extracellular, clone 8G10, culture supernatant, clone 8G10, Chemicon®,
物种反应性
mouse, rat
应用
flow cytometry
immunohistochemistry

western blot
Anti-Notch 1 Antibody, NT, serum, from rabbit,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry

western blot
抗Notch 1抗体,克隆mN1A, clone mN1A, Chemicon®, from mouse,
物种反应性
feline, mouse, rat
应用
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Notch 1 antibody, Rat monoclonal, clone ICN 5B5, purified from hybridoma cell culture,
物种反应性
human
应用
western blot

Small Molecule - Inhibitor

货号
说明
物种
DAPT, ≥98% (HPLC), solid,
物种
mouse, human, rat
L-685,458, >96% (HPLC), solid,
物种
mouse, human, rat

Proteins

货号
说明
物种
PrEST Antigen NOTCH1, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Notch1,
物种
mouse
MISSION® esiRNA, targeting human NOTCH1,
物种
human