CN
PTPN6
protein tyrosine phosphatase, non-receptor type 6
别名:
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
物种:
Human PTPN6 (5777), Mouse Ptpn6 (15170), Rat Ptpn6 (116689), Domestic Rabbit PTPN6 (100348648), naked mole-rat Ptpn6 (101725029), cow PTPN6 (512312), domestic cat PTPN6 (101087073), domestic guinea pig Ptpn6 (100723417), sheep PTPN6 (101108643), chicken PTPN6 (427947) ...展开
UniProtKB ID:
基因ID:
- Human(5777) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
- Mouse(15170) protein tyrosine phosphatase, non-receptor type 6
- Rat(116689) protein tyrosine phosphatase, non-receptor type 6
- Domestic Rabbit(100348648) protein tyrosine phosphatase, non-receptor type 6
- naked mole-rat(101725029) protein tyrosine phosphatase, non-receptor type 6
- cow(512312) protein tyrosine phosphatase, non-receptor type 6
- domestic cat(101087073) protein tyrosine phosphatase, non-receptor type 6
- domestic guinea pig(100723417) protein tyrosine phosphatase, non-receptor type 6
- sheep(101108643) protein tyrosine phosphatase, non-receptor type 6
- chicken(427947) protein tyrosine phosphatase, non-receptor type 6
- dog(486717) protein tyrosine phosphatase, non-receptor type 6
- Zebrafish(335573) protein tyrosine phosphatase, non-receptor type 6
- Horse(100052882) protein tyrosine phosphatase, non-receptor type 6
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Antibodies
货号
说明
物种反应性
应用
Anti-PTPN6 (Ab-536) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTPN6/SHP1 (Internal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
western blot
Anti-phospho-PTPN6 (pTyr536) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-phospho-SHP-1 (pTyr536) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SHP-1 Antibody, clone HG213, rabbit monoclonal, clone HG213, from rabbit, unconjugated,
物种反应性
human
应用
western blot