Merck
CN

RAF1

v-raf-1 murine leukemia viral oncogene homolog 1

别名:
CRAF, NS5, Raf-1, c-Raf
物种:
UniProtKB ID:
基因ID:
  • Human(5894) Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
  • Mouse(110157) v-raf-leukemia viral oncogene 1
  • Rat(24703) v-raf-leukemia viral oncogene 1
  • Horse(100051110) v-raf-1 murine leukemia viral oncogene homolog 1
  • domestic guinea pig(100720110) v-raf-1 murine leukemia viral oncogene homolog 1
  • Domestic Rabbit(100347407) v-raf-1 murine leukemia viral oncogene homolog 1
  • sheep(101103190) v-raf-1 murine leukemia viral oncogene homolog 1
  • cow(521196) v-raf-1 murine leukemia viral oncogene homolog 1
  • naked mole-rat(101721841) v-raf-1 murine leukemia viral oncogene homolog 1
  • chicken(396245) v-raf-1 murine leukemia viral oncogene homolog 1
  • dog(484648) v-raf-1 murine leukemia viral oncogene homolog 1
  • domestic cat(101096047) v-raf-1 murine leukemia viral oncogene homolog 1

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Antibodies

货号
说明
物种反应性
应用
Anti-Raf1 Antibody, clone 4G6C1, Rabbit Monoclonal, ,
物种反应性
human, rat
应用
western blot
Anti-Raf-1 Antibody, clone AM223, rabbit monoclonal, culture supernatant, clone AM223, from rabbit,
物种反应性
human, mouse, rat
应用
immunoprecipitation (IP)
western blot
Anti-C-RAF antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
Anti-Raf-1 Antibody, Upstate®, from rabbit,
物种反应性
human
应用
immunoprecipitation (IP)
western blot
Anti-Phospho-RAF1-S338 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
western blot

Small Molecule - Inhibitor

货号
说明
物种
GW5074, powder,
物种
human
PD 98,059, solid,
物种
human
SB 203580, solid, ≥98% (HPLC),
物种
human
腺嘌呤, ≥99%,
物种
human, rat, mouse
腺嘌呤, BioReagent, suitable for cell culture,
物种
human, rat, mouse

Proteins

货号
说明
物种
cRAF (RAF1), ,
物种
human
Raf-1 RBD Protein, GST, 300 µg, GST fusion-protein, corresponding to the human Ras Binding Domain (RBD, residues 1-149) of Raf-1, expressed in E. coli. with purity 50% at full length molecular weight 42 kDa. For use in Affinity Binding Assays,
物种
human
RAF1 (EE) (306-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
Raf-1 Protein, Active, 10 µg, Active, N-terminal GST-tagged recombinant human Raf-1 residues 306-end, containing the mutations Y340D & Y341D, for use in Kinase Assays.,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Raf1,
物种
mouse
MISSION® esiRNA, targeting human RAF1,
物种
human