DUSP8
dual specificity phosphatase 8
别名:
C11orf81, HB5, HVH-5, HVH8
物种:
Human DUSP8 (1850), Mouse Dusp8 (18218), Rat Dusp8 (361679), domestic guinea pig Dusp8 (100731539), naked mole-rat Dusp8 (101716391), dog DUSP8 (483660), chicken DUSP8 (770435)
UniProtKB ID:
基因ID:
- Human(1850) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
- Mouse(18218) dual specificity phosphatase 8
- Rat(361679) dual specificity phosphatase 8
- domestic guinea pig(100731539) dual specificity phosphatase 8
- naked mole-rat(101716391) dual specificity phosphatase 8
- dog(483660) dual specificity phosphatase 8
- chicken(770435) dual specificity phosphatase 8
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Antibodies
Product Number
说明
物种反应性
应用
Anti-DUSP8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry